Motif ID: Nkx6-2

Z-value: 1.170


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.094.1e-01Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_97584612 19.703 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 19.574 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr18_-_74207771 15.702 ENSMUST00000040188.8
ENSMUST00000177604.1
Ska1

spindle and kinetochore associated complex subunit 1

chr18_-_84086379 13.782 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr8_-_61902669 11.725 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr16_-_22161450 11.139 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr4_-_117182623 10.775 ENSMUST00000065896.2
Kif2c
kinesin family member 2C
chr17_-_48432723 10.130 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr10_+_37139558 9.906 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr5_+_92809372 9.779 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr5_+_92683625 9.697 ENSMUST00000168878.1
Shroom3
shroom family member 3
chr9_+_65890237 9.542 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr6_-_144209471 9.090 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr6_-_144209558 8.585 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr13_+_44121167 7.728 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chr1_+_184034381 7.553 ENSMUST00000048655.7
Dusp10
dual specificity phosphatase 10
chr4_-_21767173 6.605 ENSMUST00000029915.5
Tstd3
thiosulfate sulfurtransferase (rhodanese)-like domain containing 3
chr6_-_144209448 6.389 ENSMUST00000077160.5
Sox5
SRY-box containing gene 5
chr16_+_96467606 6.056 ENSMUST00000061739.8
Pcp4
Purkinje cell protein 4
chr10_+_26822560 6.004 ENSMUST00000135866.1
Arhgap18
Rho GTPase activating protein 18
chr4_-_83285141 5.595 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr9_+_96258697 5.565 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr9_+_52047150 5.520 ENSMUST00000163153.1
Rdx
radixin
chr5_+_110839973 5.452 ENSMUST00000066160.1
Chek2
checkpoint kinase 2
chr11_-_101171302 5.449 ENSMUST00000164474.1
ENSMUST00000043397.7
Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr9_+_96259246 4.790 ENSMUST00000179065.1
ENSMUST00000165768.2
Tfdp2

transcription factor Dp 2

chr2_-_125625065 4.744 ENSMUST00000089776.2
Cep152
centrosomal protein 152
chr2_-_69789568 4.476 ENSMUST00000094942.3
Ccdc173
coiled-coil domain containing 173
chr18_+_57142782 3.916 ENSMUST00000139892.1
Megf10
multiple EGF-like-domains 10
chr1_+_194619815 3.864 ENSMUST00000027952.5
Plxna2
plexin A2
chr4_-_3938354 3.842 ENSMUST00000003369.3
Plag1
pleiomorphic adenoma gene 1
chr19_+_58728887 3.787 ENSMUST00000048644.5
Pnliprp1
pancreatic lipase related protein 1
chr10_+_18407658 3.738 ENSMUST00000037341.7
Nhsl1
NHS-like 1
chr17_+_82539258 3.710 ENSMUST00000097278.3
Gm6594
predicted pseudogene 6594
chr18_-_42899294 3.700 ENSMUST00000117687.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr5_+_123142187 3.698 ENSMUST00000174836.1
ENSMUST00000163030.2
Setd1b

SET domain containing 1B

chr4_+_140701466 3.488 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr11_+_23256566 3.433 ENSMUST00000136235.1
Xpo1
exportin 1, CRM1 homolog (yeast)
chr6_+_125049952 3.423 ENSMUST00000088294.5
ENSMUST00000032481.7
Acrbp

proacrosin binding protein

chr15_-_13173607 3.195 ENSMUST00000036439.4
Cdh6
cadherin 6
chr4_-_138913915 3.164 ENSMUST00000097830.3
Otud3
OTU domain containing 3
chr11_-_17953861 3.153 ENSMUST00000076661.6
Etaa1
Ewing's tumor-associated antigen 1
chr4_-_91376433 3.138 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr4_+_98546919 3.029 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr19_-_12765447 2.997 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr1_+_15712303 2.966 ENSMUST00000170146.1
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr12_-_80760541 2.853 ENSMUST00000073251.6
Ccdc177
coiled-coil domain containing 177
chrX_-_51018011 2.831 ENSMUST00000053593.7
Rap2c
RAP2C, member of RAS oncogene family
chr4_-_133756769 2.745 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr6_+_125049903 2.704 ENSMUST00000112413.1
Acrbp
proacrosin binding protein
chr7_+_39588931 2.689 ENSMUST00000178791.1
ENSMUST00000098511.3
Gm2058

predicted gene 2058

chr19_-_44107447 2.684 ENSMUST00000119591.1
ENSMUST00000026217.4
Chuk

conserved helix-loop-helix ubiquitous kinase

chr4_+_98546710 2.673 ENSMUST00000102792.3
Inadl
InaD-like (Drosophila)
chr1_-_135585314 2.660 ENSMUST00000040599.8
ENSMUST00000067414.6
Nav1

neuron navigator 1

chr16_+_44394771 2.570 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chr15_+_34453285 2.468 ENSMUST00000060894.7
BC030476
cDNA sequence BC030476
chr17_+_35861318 2.313 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr12_-_46818749 2.251 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr11_+_20543307 2.161 ENSMUST00000093292.4
Sertad2
SERTA domain containing 2
chr2_+_69789647 2.120 ENSMUST00000112266.1
Phospho2
phosphatase, orphan 2
chr5_-_20951769 2.105 ENSMUST00000036489.5
Rsbn1l
round spermatid basic protein 1-like
chr2_+_69789621 2.104 ENSMUST00000151298.1
ENSMUST00000028494.2
Phospho2

phosphatase, orphan 2

chr2_+_62664279 2.091 ENSMUST00000028257.2
Gca
grancalcin
chr4_+_90218820 1.984 ENSMUST00000107129.1
Zfp352
zinc finger protein 352
chr2_+_69861562 1.943 ENSMUST00000090852.4
ENSMUST00000166411.1
Ssb

Sjogren syndrome antigen B

chr17_+_35861343 1.912 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr19_-_58454435 1.880 ENSMUST00000169850.1
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr4_+_3940747 1.869 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chrM_+_10167 1.730 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr3_+_103575231 1.678 ENSMUST00000121834.1
Syt6
synaptotagmin VI
chr15_+_35371498 1.676 ENSMUST00000048646.7
Vps13b
vacuolar protein sorting 13B (yeast)
chrX_+_7762652 1.657 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
Tfe3



transcription factor E3



chr18_+_61639542 1.548 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr3_-_96220880 1.539 ENSMUST00000090782.3
Hist2h2ac
histone cluster 2, H2ac
chr11_+_87663087 1.538 ENSMUST00000165679.1
Rnf43
ring finger protein 43
chr1_+_66322102 1.490 ENSMUST00000123647.1
Map2
microtubule-associated protein 2
chr2_+_22622183 1.484 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr11_+_98863610 1.345 ENSMUST00000142414.1
ENSMUST00000037480.8
Wipf2

WAS/WASL interacting protein family, member 2

chr3_+_96221111 1.316 ENSMUST00000090781.6
Hist2h2be
histone cluster 2, H2be
chr10_-_37138863 1.301 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr7_-_45062393 1.276 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr1_-_163725123 1.255 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr9_-_113708209 1.233 ENSMUST00000111861.3
ENSMUST00000035086.6
Pdcd6ip

programmed cell death 6 interacting protein

chr7_-_84679346 1.193 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6

zinc finger, AN1-type domain 6

chrX_+_75382384 1.128 ENSMUST00000033541.4
Fundc2
FUN14 domain containing 2
chr3_+_103575275 1.119 ENSMUST00000090697.4
Syt6
synaptotagmin VI
chr3_+_10088173 1.109 ENSMUST00000061419.7
Gm9833
predicted gene 9833
chr2_-_177267036 1.096 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr1_+_170308802 1.047 ENSMUST00000056991.5
1700015E13Rik
RIKEN cDNA 1700015E13 gene
chr14_+_29978337 1.012 ENSMUST00000016115.4
Actr8
ARP8 actin-related protein 8
chrM_+_9452 0.932 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr15_-_73061204 0.914 ENSMUST00000089770.3
ENSMUST00000170633.1
ENSMUST00000168191.1
Trappc9


trafficking protein particle complex 9


chr4_+_150853919 0.902 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr7_+_43690418 0.889 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chr18_+_4993795 0.831 ENSMUST00000153016.1
Svil
supervillin
chr3_+_40540751 0.816 ENSMUST00000091186.3
Intu
inturned planar cell polarity effector homolog (Drosophila)
chr2_-_84650714 0.775 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr11_-_87826023 0.772 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr18_+_6332587 0.734 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr19_-_14597983 0.712 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr2_-_84650760 0.688 ENSMUST00000111691.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr11_-_109995775 0.686 ENSMUST00000020948.8
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr11_-_109995743 0.602 ENSMUST00000106669.2
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr7_-_103741322 0.580 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr9_-_22117123 0.573 ENSMUST00000013966.6
Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr5_-_51553896 0.571 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr11_+_62879449 0.551 ENSMUST00000014321.4
Tvp23b
trans-golgi network vesicle protein 23B
chr4_-_136835843 0.536 ENSMUST00000105846.2
ENSMUST00000059287.7
ENSMUST00000105845.2
Ephb2


Eph receptor B2


chr8_+_46986913 0.485 ENSMUST00000039840.7
ENSMUST00000119686.1
Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr2_+_163694015 0.460 ENSMUST00000109400.2
Pkig
protein kinase inhibitor, gamma
chr10_+_88201087 0.438 ENSMUST00000020248.9
Ccdc53
coiled-coil domain containing 53
chr5_-_63968867 0.415 ENSMUST00000154169.1
Rell1
RELT-like 1
chr15_-_81104999 0.400 ENSMUST00000109579.2
Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr13_-_67332525 0.400 ENSMUST00000168892.1
ENSMUST00000109735.2
Zfp595

zinc finger protein 595

chr2_-_84650490 0.357 ENSMUST00000066177.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chr5_+_25246775 0.347 ENSMUST00000144971.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr1_+_34005872 0.334 ENSMUST00000182296.1
Dst
dystonin
chr1_+_66321708 0.301 ENSMUST00000114013.1
Map2
microtubule-associated protein 2
chr1_-_63176653 0.287 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr18_+_34840575 0.282 ENSMUST00000043484.7
Reep2
receptor accessory protein 2
chr2_-_84650676 0.280 ENSMUST00000067232.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chr5_-_110839575 0.272 ENSMUST00000145318.1
Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr1_-_185329331 0.259 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr19_-_14598031 0.249 ENSMUST00000167776.2
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr3_+_19894855 0.144 ENSMUST00000059704.4
4632415L05Rik
RIKEN cDNA 4632415L05 gene
chr5_-_122821298 0.124 ENSMUST00000086216.4
Anapc5
anaphase-promoting complex subunit 5
chr10_+_88201158 0.122 ENSMUST00000171151.2
Ccdc53
coiled-coil domain containing 53
chr10_+_19951055 0.102 ENSMUST00000152533.1
Map3k5
mitogen-activated protein kinase kinase kinase 5
chr2_+_3114220 0.072 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr11_-_31671727 0.021 ENSMUST00000109415.1
Bod1
biorientation of chromosomes in cell division 1
chr2_-_37647199 0.000 ENSMUST00000028279.3
Strbp
spermatid perinuclear RNA binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0060023 soft palate development(GO:0060023)
3.4 10.1 GO:0016554 cytidine to uridine editing(GO:0016554)
3.0 24.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
2.2 10.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.5 7.6 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.4 5.5 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
1.1 3.2 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
1.0 3.0 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.9 2.8 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.8 5.5 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.7 4.7 GO:0098535 de novo centriole assembly(GO:0098535)
0.7 3.9 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.7 11.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.6 6.1 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.6 3.5 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.5 1.9 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.5 3.9 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.5 3.7 GO:0097475 motor neuron migration(GO:0097475)
0.4 3.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.4 2.1 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.4 1.2 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.4 2.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.3 2.7 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.3 6.1 GO:0048240 sperm capacitation(GO:0048240)
0.3 1.5 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.3 0.9 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.3 1.5 GO:0006538 glutamate catabolic process(GO:0006538)
0.3 3.7 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.3 19.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.3 1.1 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.2 3.8 GO:0060736 prostate gland growth(GO:0060736)
0.2 2.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 3.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.6 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.1 0.5 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 1.3 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.1 0.9 GO:0007320 insemination(GO:0007320)
0.1 1.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.5 GO:0019695 choline metabolic process(GO:0019695)
0.1 10.5 GO:0051028 mRNA transport(GO:0051028)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.8 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 8.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 1.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.3 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 1.2 GO:0006625 protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.3 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 6.0 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.9 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.6 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 2.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 4.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.6 GO:0007608 sensory perception of smell(GO:0007608)
0.0 3.2 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 3.0 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 1.5 GO:0006342 chromatin silencing(GO:0006342)
0.0 2.3 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 2.2 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.1 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 15.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.0 3.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.8 4.7 GO:0098536 deuterosome(GO:0098536)
0.7 6.1 GO:0005883 neurofilament(GO:0005883)
0.4 1.3 GO:0042585 germinal vesicle(GO:0042585)
0.3 5.5 GO:0051286 cell tip(GO:0051286)
0.3 3.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.3 3.4 GO:0005642 annulate lamellae(GO:0005642)
0.3 10.8 GO:0035371 microtubule plus-end(GO:0035371)
0.3 11.7 GO:0002102 podosome(GO:0002102)
0.2 4.2 GO:0005652 nuclear lamina(GO:0005652)
0.2 2.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 3.9 GO:0001891 phagocytic cup(GO:0001891)
0.2 1.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 2.1 GO:0005915 zonula adherens(GO:0005915)
0.2 34.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 1.2 GO:0090543 Flemming body(GO:0090543)
0.1 2.7 GO:0071564 npBAF complex(GO:0071564)
0.1 2.7 GO:0043194 axon initial segment(GO:0043194)
0.1 3.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 2.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 14.6 GO:0043296 apical junction complex(GO:0043296)
0.1 3.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.0 GO:0031011 Ino80 complex(GO:0031011)
0.1 6.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.9 GO:0030008 TRAPP complex(GO:0030008)
0.1 5.5 GO:0016605 PML body(GO:0016605)
0.1 2.1 GO:0043596 nuclear replication fork(GO:0043596)
0.0 17.4 GO:0016607 nuclear speck(GO:0016607)
0.0 2.9 GO:0000786 nucleosome(GO:0000786)
0.0 1.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.9 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 1.9 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.1 GO:0004126 cytidine deaminase activity(GO:0004126)
1.3 6.6 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
1.1 4.2 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.9 2.7 GO:0008384 IkappaB kinase activity(GO:0008384)
0.6 10.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.6 3.9 GO:0001849 complement component C1q binding(GO:0001849)
0.5 7.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.4 3.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.4 1.2 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.4 11.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 3.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 3.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 3.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 1.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 1.5 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 1.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 3.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 6.1 GO:0016504 peptidase activator activity(GO:0016504)
0.1 2.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 21.6 GO:0051015 actin filament binding(GO:0051015)
0.1 2.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 3.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 3.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 1.3 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 19.3 GO:0003779 actin binding(GO:0003779)
0.1 13.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 3.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 2.8 GO:0019003 GDP binding(GO:0019003)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.0 30.6 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 1.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 4.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 6.2 GO:0008017 microtubule binding(GO:0008017)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 7.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 2.1 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 6.5 GO:0019901 protein kinase binding(GO:0019901)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 6.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 7.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 12.0 PID_E2F_PATHWAY E2F transcription factor network
0.1 5.5 PID_ATM_PATHWAY ATM pathway
0.1 5.9 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 3.7 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.5 PID_P73PATHWAY p73 transcription factor network
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 10.8 REACTOME_KINESINS Genes involved in Kinesins
0.3 3.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 2.7 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 3.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 19.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 5.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 1.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 5.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 2.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 3.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.6 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 1.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 6.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation