Motif ID: Nkx6-2

Z-value: 1.170


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.094.1e-01Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 131 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_97584612 19.703 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 19.574 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr18_-_74207771 15.702 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr18_-_84086379 13.782 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr8_-_61902669 11.725 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr16_-_22161450 11.139 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr4_-_117182623 10.775 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr17_-_48432723 10.130 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr10_+_37139558 9.906 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr5_+_92809372 9.779 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr5_+_92683625 9.697 ENSMUST00000168878.1
 Shroom3
shroom family member 3
chr9_+_65890237 9.542 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr6_-_144209471 9.090 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 8.585 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr13_+_44121167 7.728 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr1_+_184034381 7.553 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr4_-_21767173 6.605 ENSMUST00000029915.5
 Tstd3
thiosulfate sulfurtransferase (rhodanese)-like domain containing 3
chr6_-_144209448 6.389 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr16_+_96467606 6.056 ENSMUST00000061739.8
 Pcp4
Purkinje cell protein 4
chr10_+_26822560 6.004 ENSMUST00000135866.1
 Arhgap18
Rho GTPase activating protein 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 24.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.3 19.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
4.6 13.8 GO:0060023 soft palate development(GO:0060023)
0.7 11.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
2.2 10.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 10.5 GO:0051028 mRNA transport(GO:0051028)
3.4 10.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 8.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
1.5 7.6 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.6 6.1 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.3 6.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 6.0 GO:0030833 regulation of actin filament polymerization(GO:0030833)
1.4 5.5 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.8 5.5 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.7 4.7 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 4.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.7 3.9 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.5 3.9 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.2 3.8 GO:0060736 prostate gland growth(GO:0060736)
0.5 3.7 GO:0097475 motor neuron migration(GO:0097475)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 34.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 17.4 GO:0016607 nuclear speck(GO:0016607)
1.2 15.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 14.6 GO:0043296 apical junction complex(GO:0043296)
0.3 11.7 GO:0002102 podosome(GO:0002102)
0.3 10.8 GO:0035371 microtubule plus-end(GO:0035371)
0.7 6.1 GO:0005883 neurofilament(GO:0005883)
0.1 6.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 5.5 GO:0051286 cell tip(GO:0051286)
0.1 5.5 GO:0016605 PML body(GO:0016605)
0.8 4.7 GO:0098536 deuterosome(GO:0098536)
0.2 4.2 GO:0005652 nuclear lamina(GO:0005652)
0.2 3.9 GO:0001891 phagocytic cup(GO:0001891)
0.3 3.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.3 3.4 GO:0005642 annulate lamellae(GO:0005642)
0.1 3.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
1.0 3.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 3.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.9 GO:0000786 nucleosome(GO:0000786)
0.0 2.9 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 30.6 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 21.6 GO:0051015 actin filament binding(GO:0051015)
0.1 19.3 GO:0003779 actin binding(GO:0003779)
0.1 13.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 11.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 10.8 GO:0051010 microtubule plus-end binding(GO:0051010)
2.5 10.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.5 7.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 7.2 GO:0045296 cadherin binding(GO:0045296)
1.3 6.6 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 6.5 GO:0019901 protein kinase binding(GO:0019901)
0.0 6.2 GO:0008017 microtubule binding(GO:0008017)
0.1 6.1 GO:0016504 peptidase activator activity(GO:0016504)
0.0 4.6 GO:0005516 calmodulin binding(GO:0005516)
1.1 4.2 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.6 3.9 GO:0001849 complement component C1q binding(GO:0001849)
0.3 3.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.3 3.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 3.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 3.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.0 PID_E2F_PATHWAY E2F transcription factor network
0.2 10.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 7.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.2 6.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 5.9 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 5.5 PID_ATM_PATHWAY ATM pathway
0.1 3.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.5 PID_P73PATHWAY p73 transcription factor network
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 10.8 REACTOME_KINESINS Genes involved in Kinesins
0.0 6.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.5 5.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 5.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.2 3.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 3.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 3.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 2.7 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.6 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.1 1.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 1.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation