Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.598

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene SymbolEntrez IDGene Name
Barx2 ENSMUSG00000032033.10 Barx2
Dbx2 ENSMUSG00000045608.6 Dbx2
Nkx6-3 ENSMUSG00000063672.6 Nkx6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dbx2mm10_v2_chr15_-_95655960_956559600.403.6e-04Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-3_Dbx2_Barx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 17.197 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 9.772 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr4_+_136143497 9.153 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr4_-_14621669 8.725 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr13_+_94083490 6.058 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr4_+_102589687 5.565 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr14_+_80000292 4.560 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr5_-_118244861 3.658 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr15_-_8710734 3.629 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr17_-_81649607 3.595 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr5_-_70842617 3.392 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr15_-_8710409 3.173 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_144100387 3.060 ENSMUST00000041804.7
Lmtk2
lemur tyrosine kinase 2
chr2_+_109917639 2.964 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr19_-_57239310 2.926 ENSMUST00000111559.1
Ablim1
actin-binding LIM protein 1
chr2_+_125136692 2.848 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr15_-_33687840 2.746 ENSMUST00000042021.3
Tspyl5
testis-specific protein, Y-encoded-like 5
chr14_+_69347587 2.742 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr8_-_21906412 2.723 ENSMUST00000051965.4
Defb11
defensin beta 11
chr13_-_105054895 2.690 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 35.7 GO:0019532 oxalate transport(GO:0019532)
0.3 9.2 GO:0030903 notochord development(GO:0030903)
0.6 7.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.7 6.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.9 5.3 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 4.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 4.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.1 4.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.7 3.6 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.4 3.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 3.1 GO:0033572 transferrin transport(GO:0033572)
1.0 3.0 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 2.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.9 2.8 GO:0015866 ADP transport(GO:0015866)
0.1 2.7 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.6 2.5 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 1.8 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0 1.7 GO:0042742 defense response to bacterium(GO:0042742)
0.5 1.6 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 37.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 5.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 4.7 GO:0034707 chloride channel complex(GO:0034707)
0.3 4.6 GO:0042581 specific granule(GO:0042581)
0.0 4.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.1 GO:0055037 recycling endosome(GO:0055037)
0.0 2.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9 2.7 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 2.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.9 GO:0016235 aggresome(GO:0016235)
0.1 1.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2 1.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.9 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 35.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 9.2 GO:0005504 fatty acid binding(GO:0005504)
1.1 6.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 6.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.8 5.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 4.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 4.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.9 3.6 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 3.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.5 3.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 3.0 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.9 2.8 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.4 2.7 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.5 2.6 GO:0019770 IgG receptor activity(GO:0019770)
0.1 2.5 GO:0004601 peroxidase activity(GO:0004601)
0.2 2.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 1.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 1.4 GO:0005351 sugar:proton symporter activity(GO:0005351)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 0.9 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.8 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 46.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 7.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 3.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 2.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.0 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects