ISMARA results: Nkx6-3_Dbx2

Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.598

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene Symbol	Entrez ID	Gene Name
Barx2	ENSMUSG00000032033.10	Barx2
Dbx2	ENSMUSG00000045608.6	Dbx2
Nkx6-3	ENSMUSG00000063672.6	Nkx6-3

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Dbx2	mm10_v2_chr15_-_95655960_95655960	0.40	3.6e-04	Click!

Sorted Z-values for motif Nkx6-3_Dbx2_Barx2

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Top targets:

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Showing 1 to 20 of 140 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr4_-_14621805	17.197	ENSMUST00000042221.7	Slc26a7	solute carrier family 26, member 7
chr4_-_14621494	9.772	ENSMUST00000149633.1	Slc26a7	solute carrier family 26, member 7
chr4_+_136143497	9.153	ENSMUST00000008016.2	Id3	inhibitor of DNA binding 3
chr4_-_14621669	8.725	ENSMUST00000143105.1	Slc26a7	solute carrier family 26, member 7
chr13_+_94083490	6.058	ENSMUST00000156071.1	Lhfpl2	lipoma HMGIC fusion partner-like 2
chr4_+_102589687	5.565	ENSMUST00000097949.4 ENSMUST00000106901.1	Pde4b	phosphodiesterase 4B, cAMP specific
chr14_+_80000292	4.560	ENSMUST00000088735.3	Olfm4	olfactomedin 4
chr5_-_118244861	3.658	ENSMUST00000117177.1 ENSMUST00000133372.1 ENSMUST00000154786.1 ENSMUST00000121369.1	Rnft2	ring finger protein, transmembrane 2
chr15_-_8710734	3.629	ENSMUST00000005493.7	Slc1a3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr17_-_81649607	3.595	ENSMUST00000163680.2 ENSMUST00000086538.3 ENSMUST00000163123.1	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_-_70842617	3.392	ENSMUST00000031119.1	Gabrg1	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr15_-_8710409	3.173	ENSMUST00000157065.1	Slc1a3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_144100387	3.060	ENSMUST00000041804.7	Lmtk2	lemur tyrosine kinase 2
chr2_+_109917639	2.964	ENSMUST00000046548.7 ENSMUST00000111037.2	Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4
chr19_-_57239310	2.926	ENSMUST00000111559.1	Ablim1	actin-binding LIM protein 1
chr2_+_125136692	2.848	ENSMUST00000099452.2	Ctxn2	cortexin 2
chr15_-_33687840	2.746	ENSMUST00000042021.3	Tspyl5	testis-specific protein, Y-encoded-like 5
chr14_+_69347587	2.742	ENSMUST00000064831.5	Entpd4	ectonucleoside triphosphate diphosphohydrolase 4
chr8_-_21906412	2.723	ENSMUST00000051965.4	Defb11	defensin beta 11
chr13_-_105054895	2.690	ENSMUST00000063551.5	Rgs7bp	regulator of G-protein signalling 7 binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 54 entries

Log-likelihood per target	Total log-likelihood	Term	Description
5.1	35.7	GO:0019532	oxalate transport(GO:0019532)
0.3	9.2	GO:0030903	notochord development(GO:0030903)
0.6	7.3	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
1.7	6.8	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.9	5.3	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.2	4.7	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1	4.6	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.1	4.3	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.7	3.6	GO:0098735	cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.4	3.3	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.2	3.1	GO:0033572	transferrin transport(GO:0033572)
1.0	3.0	GO:0072204	cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0	2.9	GO:0030032	lamellipodium assembly(GO:0030032)
0.9	2.8	GO:0015866	ADP transport(GO:0015866)
0.1	2.7	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.6	2.5	GO:0010700	negative regulation of norepinephrine secretion(GO:0010700)
0.0	2.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3	1.8	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0	1.7	GO:0042742	defense response to bacterium(GO:0042742)
0.5	1.6	GO:1903903	regulation of establishment of T cell polarity(GO:1903903)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 32 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	37.4	GO:0016323	basolateral plasma membrane(GO:0016323)
0.2	5.6	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	4.7	GO:0034707	chloride channel complex(GO:0034707)
0.3	4.6	GO:0042581	specific granule(GO:0042581)
0.0	4.6	GO:0000139	Golgi membrane(GO:0000139)
0.0	3.1	GO:0055037	recycling endosome(GO:0055037)
0.0	2.9	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9	2.7	GO:0097637	intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0	2.5	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	1.9	GO:0016235	aggresome(GO:0016235)
0.1	1.8	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	1.7	GO:0035371	microtubule plus-end(GO:0035371)
0.0	1.7	GO:0001669	acrosomal vesicle(GO:0001669)
0.2	1.6	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	1.3	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2	1.1	GO:0097524	sperm plasma membrane(GO:0097524)
0.1	1.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	0.9	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.1	0.9	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 40 entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.2	35.7	GO:0019531	secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2	9.2	GO:0005504	fatty acid binding(GO:0005504)
1.1	6.8	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.2	6.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.8	5.3	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3	4.7	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	4.3	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.9	3.6	GO:0086038	calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1	3.6	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.5	3.3	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2	3.0	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.9	2.8	GO:0015228	coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.4	2.7	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.5	2.6	GO:0019770	IgG receptor activity(GO:0019770)
0.1	2.5	GO:0004601	peroxidase activity(GO:0004601)
0.2	2.3	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.1	1.8	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.1	1.7	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	1.6	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.1	1.4	GO:0005351	sugar:proton symporter activity(GO:0005351)

Gene overrepresentation in C2:CP category:

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Showing 1 to 6 of 6 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.3	PID_RHOA_REG_PATHWAY	Regulation of RhoA activity
0.0	1.6	PID_TAP63_PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	0.9	ST_INTERFERON_GAMMA_PATHWAY	Interferon gamma pathway.
0.0	0.8	PID_IL2_PI3K_PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.7	PID_SYNDECAN_3_PATHWAY	Syndecan-3-mediated signaling events
0.0	0.5	ST_MYOCYTE_AD_PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 16 of 16 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	46.7	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	7.3	REACTOME_DARPP_32_EVENTS	Genes involved in DARPP-32 events
0.0	3.6	REACTOME_SIGNALING_BY_RHO_GTPASES	Genes involved in Signaling by Rho GTPases
0.1	2.9	REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING	Genes involved in DCC mediated attractive signaling
0.3	2.3	REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.1	2.0	REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.1	1.8	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.4	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1	1.3	REACTOME_GABA_A_RECEPTOR_ACTIVATION	Genes involved in GABA A receptor activation
0.0	1.1	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.8	REACTOME_ER_PHAGOSOME_PATHWAY	Genes involved in ER-Phagosome pathway
0.0	0.6	REACTOME_ZINC_TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.5	REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.4	REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.3	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.3	REACTOME_CGMP_EFFECTS	Genes involved in cGMP effects