Motif ID: Nr0b1

Z-value: 1.086


Transcription factors associated with Nr0b1:

Gene SymbolEntrez IDGene Name
Nr0b1 ENSMUSG00000025056.4 Nr0b1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr0b1mm10_v2_chrX_+_86191764_861917820.161.6e-01Click!


Activity profile for motif Nr0b1.

activity profile for motif Nr0b1


Sorted Z-values histogram for motif Nr0b1

Sorted Z-values for motif Nr0b1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr0b1

PNG image of the network

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Top targets:


Showing 1 to 20 of 86 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_45844228 15.295 ENSMUST00000076333.5
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844303 14.948 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr11_+_102604370 11.787 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr7_+_79500081 11.599 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr9_+_80165079 11.015 ENSMUST00000184480.1
 Myo6
myosin VI
chr7_+_79500018 10.828 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr9_+_80165013 9.873 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr5_+_64803513 8.975 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr1_-_9700209 8.211 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chrX_-_145505175 7.854 ENSMUST00000143610.1
 Amot
angiomotin
chr18_+_35829798 6.919 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr4_-_132422484 6.815 ENSMUST00000102568.3
 Phactr4
phosphatase and actin regulator 4
chr17_-_70851189 6.503 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr10_-_81350389 6.474 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
 Hmg20b



high mobility group 20B



chr4_-_132422394 6.372 ENSMUST00000152271.1
ENSMUST00000084170.5
 Phactr4

phosphatase and actin regulator 4

chr1_+_42697146 6.189 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr4_+_116221633 5.918 ENSMUST00000030464.7
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr14_+_11553523 5.879 ENSMUST00000022264.6
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr13_-_29984219 5.680 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr3_-_123690806 5.523 ENSMUST00000154668.1
 Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 30.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.6 20.9 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.4 15.6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
3.3 13.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
2.4 11.8 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223) hard palate development(GO:0060022)
0.2 9.2 GO:0007520 myoblast fusion(GO:0007520)
0.0 9.0 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 8.2 GO:0000278 mitotic cell cycle(GO:0000278)
2.0 7.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.4 6.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 6.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.5 6.2 GO:0072236 DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240)
0.9 6.1 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.9 5.7 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.9 5.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
1.3 5.2 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 5.2 GO:1901998 toxin transport(GO:1901998)
0.3 4.5 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.2 3.9 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 3.9 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 30.2 GO:0045180 basal cortex(GO:0045180)
0.0 29.5 GO:0005654 nucleoplasm(GO:0005654)
0.8 20.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.7 15.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 12.5 GO:0030027 lamellipodium(GO:0030027)
0.0 11.7 GO:0005925 focal adhesion(GO:0005925)
0.0 10.4 GO:0031965 nuclear membrane(GO:0031965)
0.2 7.9 GO:0008180 COP9 signalosome(GO:0008180)
1.6 6.5 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 5.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 5.2 GO:0031252 cell leading edge(GO:0031252)
0.0 4.3 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.9 GO:0097440 apical dendrite(GO:0097440)
0.9 3.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 2.9 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.2 2.4 GO:0045298 tubulin complex(GO:0045298)
0.2 2.4 GO:0030056 hemidesmosome(GO:0030056)
0.2 2.4 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 2.3 GO:0005923 bicellular tight junction(GO:0005923)
0.3 2.2 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 20.9 GO:0003774 motor activity(GO:0003774)
2.2 15.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 13.9 GO:0045296 cadherin binding(GO:0045296)
2.6 13.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.5 11.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 9.5 GO:0008432 JUN kinase binding(GO:0008432)
0.2 9.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
1.0 8.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.6 7.9 GO:0043532 angiostatin binding(GO:0043532)
0.3 6.5 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 6.2 GO:0071837 HMG box domain binding(GO:0071837)
1.5 6.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 6.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 5.7 GO:0001047 core promoter binding(GO:0001047)
1.4 5.5 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.6 5.2 GO:0030274 LIM domain binding(GO:0030274)
0.1 3.9 GO:0051018 protein kinase A binding(GO:0051018)
0.0 3.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 3.4 GO:0032794 GTPase activating protein binding(GO:0032794)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.4 15.6 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.5 14.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 8.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 6.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 5.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 3.8 PID_PLK1_PATHWAY PLK1 signaling events
0.2 3.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.3 2.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.2 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.2 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 2.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 1.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 20.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
1.3 15.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 11.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 10.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 6.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 6.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 6.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 5.7 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 5.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 3.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 2.4 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.9 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.0 1.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery