Motif ID: Nr1h2

Z-value: 0.958


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.859.5e-23Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 19.092 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr11_-_60210410 15.677 ENSMUST00000144942.1
 Srebf1
sterol regulatory element binding transcription factor 1
chr7_-_97417730 14.004 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr5_+_123015010 9.078 ENSMUST00000121652.1
ENSMUST00000051016.4
 Orai1

ORAI calcium release-activated calcium modulator 1

chr1_+_135729147 7.962 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr16_-_37384915 7.915 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr15_+_79895017 7.453 ENSMUST00000023054.7
 Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr11_-_69948145 6.852 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr16_-_37384940 6.687 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chrX_-_102644210 6.608 ENSMUST00000052012.7
ENSMUST00000043596.5
ENSMUST00000119229.1
ENSMUST00000122022.1
ENSMUST00000120270.1
ENSMUST00000113611.2
 Phka1





phosphorylase kinase alpha 1





chr7_+_114768736 6.208 ENSMUST00000117543.1
 Insc
inscuteable homolog (Drosophila)
chr2_+_102658640 5.754 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_+_58711488 5.558 ENSMUST00000097722.2
ENSMUST00000114313.1
 Cflar

CASP8 and FADD-like apoptosis regulator

chr5_-_124327883 5.356 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr3_+_62419668 4.748 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr8_-_84773381 4.741 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr13_+_44729794 4.658 ENSMUST00000172830.1
 Jarid2
jumonji, AT rich interactive domain 2
chr6_-_134632388 4.339 ENSMUST00000047443.3
 Mansc1
MANSC domain containing 1
chr2_+_131491764 4.033 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
 Smox






spermine oxidase






chr7_+_97453204 4.030 ENSMUST00000050732.7
ENSMUST00000121987.1
 Kctd14

potassium channel tetramerisation domain containing 14


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 19.1 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
2.0 15.7 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.3 14.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.6 14.0 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.5 9.1 GO:0002115 store-operated calcium entry(GO:0002115)
1.8 8.8 GO:0046208 spermine catabolic process(GO:0046208)
0.1 8.0 GO:0070527 platelet aggregation(GO:0070527)
1.2 7.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.7 7.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.3 6.9 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 6.6 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.1 6.2 GO:0060487 lung epithelial cell differentiation(GO:0060487)
1.5 5.8 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
1.0 5.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.9 5.6 GO:0014891 striated muscle atrophy(GO:0014891)
0.4 4.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 4.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 4.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 4.0 GO:0016486 peptide hormone processing(GO:0016486)
0.6 3.9 GO:0002317 plasma cell differentiation(GO:0002317)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 19.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 13.8 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 9.1 GO:0030426 growth cone(GO:0030426)
0.0 8.0 GO:0005925 focal adhesion(GO:0005925)
0.0 7.4 GO:0005815 microtubule organizing center(GO:0005815)
0.1 7.1 GO:0072686 mitotic spindle(GO:0072686)
0.4 6.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.9 6.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 5.9 GO:0005814 centriole(GO:0005814)
0.1 5.8 GO:0030673 axolemma(GO:0030673)
0.9 5.6 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 5.0 GO:0030141 secretory granule(GO:0030141)
0.2 4.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 4.0 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.5 2.5 GO:0031523 Myb complex(GO:0031523)
0.0 2.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.3 GO:0005938 cell cortex(GO:0005938)
0.1 2.1 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 19.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 15.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 14.6 GO:0019905 syntaxin binding(GO:0019905)
0.0 11.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.8 9.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
1.9 7.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 7.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.7 6.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.9 6.6 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 5.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.0 5.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 5.8 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.6 5.6 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
1.6 4.7 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.1 4.7 GO:0032452 histone demethylase activity(GO:0032452)
1.3 4.0 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 3.8 GO:0005178 integrin binding(GO:0005178)
0.9 3.5 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.8 3.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.6 2.8 GO:0070330 aromatase activity(GO:0070330)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 34.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 9.1 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.2 6.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.7 5.6 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 4.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 3.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 1.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.9 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 1.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 19.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 15.7 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
1.5 9.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.5 8.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.4 7.1 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.6 6.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.5 6.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.3 6.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 5.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.4 5.6 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 3.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.4 2.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 2.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.9 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.1 1.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.4 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.3 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.1 1.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism