Motif ID: Nr1h4

Z-value: 0.710


Transcription factors associated with Nr1h4:

Gene SymbolEntrez IDGene Name
Nr1h4 ENSMUSG00000047638.9 Nr1h4



Activity profile for motif Nr1h4.

activity profile for motif Nr1h4


Sorted Z-values histogram for motif Nr1h4

Sorted Z-values for motif Nr1h4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h4

PNG image of the network

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Top targets:


Showing 1 to 20 of 131 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_50752758 7.687 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr4_+_42916647 7.024 ENSMUST00000132173.1
ENSMUST00000107975.1
 N28178

expressed sequence N28178

chr15_+_80287234 6.571 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr10_+_13966268 6.123 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr7_+_19176416 5.753 ENSMUST00000117338.1
 Eml2
echinoderm microtubule associated protein like 2
chr8_+_94179089 5.733 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr4_+_42917234 5.728 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr19_+_6400523 5.223 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr4_-_15149755 4.912 ENSMUST00000108273.1
 Necab1
N-terminal EF-hand calcium binding protein 1
chr6_-_124769548 4.748 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr4_+_117849361 4.466 ENSMUST00000163288.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_99695809 4.446 ENSMUST00000107086.2
 Slco2b1
solute carrier organic anion transporter family, member 2b1
chr4_+_117849193 4.360 ENSMUST00000132043.2
ENSMUST00000169990.1
 Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr19_+_5474681 3.878 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
 Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr1_+_75507077 3.864 ENSMUST00000037330.4
 Inha
inhibin alpha
chr7_-_105482197 3.823 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr6_-_59426279 3.678 ENSMUST00000051065.4
 Gprin3
GPRIN family member 3
chr11_-_74590065 3.482 ENSMUST00000145524.1
ENSMUST00000047488.7
 Rap1gap2

RAP1 GTPase activating protein 2

chr10_-_33995054 3.409 ENSMUST00000164429.1
 Gm17567
predicted gene, 17567
chrX_+_73064787 3.363 ENSMUST00000060418.6
 Pnma3
paraneoplastic antigen MA3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 8.8 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.3 7.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 6.6 GO:0030431 sleep(GO:0030431)
0.0 6.6 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.1 6.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.8 5.8 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.8 5.7 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
0.0 5.6 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 4.7 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.4 4.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.6 3.9 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.6 3.2 GO:0015871 choline transport(GO:0015871)
0.5 2.9 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
0.4 2.5 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 2.5 GO:0014047 glutamate secretion(GO:0014047)
0.1 2.5 GO:0071625 vocalization behavior(GO:0071625)
0.0 2.4 GO:0050919 negative chemotaxis(GO:0050919)
0.6 2.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.5 2.3 GO:2001025 positive regulation of response to drug(GO:2001025)
0.4 1.9 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0098793 presynapse(GO:0098793)
1.3 7.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 7.5 GO:0031965 nuclear membrane(GO:0031965)
0.1 4.9 GO:0072686 mitotic spindle(GO:0072686)
0.5 4.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 4.4 GO:0009925 basal plasma membrane(GO:0009925)
1.3 3.9 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.0 3.8 GO:0043235 receptor complex(GO:0043235)
0.0 2.6 GO:0030141 secretory granule(GO:0030141)
0.4 2.5 GO:0097513 myosin II filament(GO:0097513)
0.3 2.5 GO:0001520 outer dense fiber(GO:0001520)
0.0 2.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.3 GO:1990635 proximal dendrite(GO:1990635)
0.6 1.9 GO:0045160 myosin I complex(GO:0045160)
0.4 1.8 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 1.8 GO:0033269 internode region of axon(GO:0033269)
0.0 1.8 GO:0005770 late endosome(GO:0005770)
0.0 1.7 GO:0055037 recycling endosome(GO:0055037)
0.0 1.6 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.6 GO:0010008 endosome membrane(GO:0010008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0005509 calcium ion binding(GO:0005509)
0.9 8.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.9 7.7 GO:0005212 structural constituent of eye lens(GO:0005212)
1.6 6.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 5.7 GO:0005507 copper ion binding(GO:0005507)
0.1 5.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 5.1 GO:0008022 protein C-terminus binding(GO:0008022)
0.5 4.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 4.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.3 4.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.6 4.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.4 3.9 GO:0034711 inhibin binding(GO:0034711)
0.8 3.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.4 2.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 2.7 GO:0051117 ATPase binding(GO:0051117)
0.0 2.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 2.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 2.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 2.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 1.8 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 5.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 2.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.9 8.9 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 6.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.6 4.4 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
1.0 3.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 3.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 2.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 2.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 2.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 1.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.3 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 1.2 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.1 0.9 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle