Motif ID: Nr1h4

Z-value: 0.710


Transcription factors associated with Nr1h4:

Gene SymbolEntrez IDGene Name
Nr1h4 ENSMUSG00000047638.9 Nr1h4



Activity profile for motif Nr1h4.

activity profile for motif Nr1h4


Sorted Z-values histogram for motif Nr1h4

Sorted Z-values for motif Nr1h4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_50752758 7.687 ENSMUST00000034562.7
Cryab
crystallin, alpha B
chr4_+_42916647 7.024 ENSMUST00000132173.1
ENSMUST00000107975.1
N28178

expressed sequence N28178

chr15_+_80287234 6.571 ENSMUST00000160424.1
Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr10_+_13966268 6.123 ENSMUST00000015645.4
Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr7_+_19176416 5.753 ENSMUST00000117338.1
Eml2
echinoderm microtubule associated protein like 2
chr8_+_94179089 5.733 ENSMUST00000034215.6
Mt1
metallothionein 1
chr4_+_42917234 5.728 ENSMUST00000107976.2
ENSMUST00000069184.2
N28178

expressed sequence N28178

chr19_+_6400523 5.223 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
Rasgrp2



RAS, guanyl releasing protein 2



chr4_-_15149755 4.912 ENSMUST00000108273.1
Necab1
N-terminal EF-hand calcium binding protein 1
chr6_-_124769548 4.748 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
Eno2


enolase 2, gamma neuronal


chr4_+_117849361 4.466 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_99695809 4.446 ENSMUST00000107086.2
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr4_+_117849193 4.360 ENSMUST00000132043.2
ENSMUST00000169990.1
Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr19_+_5474681 3.878 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr1_+_75507077 3.864 ENSMUST00000037330.4
Inha
inhibin alpha
chr7_-_105482197 3.823 ENSMUST00000047040.2
Prkcdbp
protein kinase C, delta binding protein
chr6_-_59426279 3.678 ENSMUST00000051065.4
Gprin3
GPRIN family member 3
chr11_-_74590065 3.482 ENSMUST00000145524.1
ENSMUST00000047488.7
Rap1gap2

RAP1 GTPase activating protein 2

chr10_-_33995054 3.409 ENSMUST00000164429.1
Gm17567
predicted gene, 17567
chrX_+_73064787 3.363 ENSMUST00000060418.6
Pnma3
paraneoplastic antigen MA3
chr4_+_53440388 3.188 ENSMUST00000102911.3
ENSMUST00000107646.2
Slc44a1

solute carrier family 44, member 1

chr11_-_74590186 3.151 ENSMUST00000102521.1
Rap1gap2
RAP1 GTPase activating protein 2
chr11_+_97685794 2.904 ENSMUST00000107584.1
ENSMUST00000107585.2
Cisd3

CDGSH iron sulfur domain 3

chr5_-_147725988 2.883 ENSMUST00000110529.1
ENSMUST00000031652.3
ENSMUST00000031653.5
Flt1


FMS-like tyrosine kinase 1


chr2_-_152951688 2.803 ENSMUST00000109811.3
Dusp15
dual specificity phosphatase-like 15
chr2_-_152951547 2.769 ENSMUST00000037715.6
Dusp15
dual specificity phosphatase-like 15
chr9_-_20879718 2.612 ENSMUST00000043726.6
Angptl6
angiopoietin-like 6
chr19_+_6400611 2.610 ENSMUST00000113467.1
Rasgrp2
RAS, guanyl releasing protein 2
chr2_+_32621750 2.525 ENSMUST00000113278.2
Ak1
adenylate kinase 1
chr9_-_106656081 2.510 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr7_-_44670820 2.510 ENSMUST00000048102.7
Myh14
myosin, heavy polypeptide 14
chr19_+_44992127 2.445 ENSMUST00000179305.1
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr4_-_123116686 2.418 ENSMUST00000166337.1
Gm17244
predicted gene, 17244
chr7_+_16310412 2.330 ENSMUST00000136781.1
Bbc3
BCL2 binding component 3
chr7_-_47133684 2.251 ENSMUST00000102626.1
Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr14_-_26170283 2.229 ENSMUST00000100809.4
Plac9b
placenta specific 9b
chr11_+_97685903 2.038 ENSMUST00000107583.2
Cisd3
CDGSH iron sulfur domain 3
chr11_+_75655873 1.948 ENSMUST00000108431.2
Myo1c
myosin IC
chr5_-_116422858 1.939 ENSMUST00000036991.4
Hspb8
heat shock protein 8
chr10_-_89732253 1.893 ENSMUST00000020109.3
Actr6
ARP6 actin-related protein 6
chr17_-_57087729 1.849 ENSMUST00000071135.5
Tubb4a
tubulin, beta 4A class IVA
chr1_+_152954966 1.810 ENSMUST00000043313.8
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr4_-_42528175 1.730 ENSMUST00000180201.1
Gm13298
predicted gene 13298
chr5_-_36582381 1.686 ENSMUST00000141043.1
ENSMUST00000031094.8
Tbc1d14

TBC1 domain family, member 14

chr10_-_78298162 1.656 ENSMUST00000105389.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr8_+_25720054 1.655 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr4_-_141664063 1.624 ENSMUST00000084203.4
Plekhm2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chrX_+_77511002 1.586 ENSMUST00000088217.5
Tbl1x
transducin (beta)-like 1 X-linked
chr2_-_130638094 1.554 ENSMUST00000089561.3
ENSMUST00000110260.1
Lzts3

leucine zipper, putative tumor suppressor family member 3

chr4_-_108406676 1.527 ENSMUST00000184609.1
Gpx7
glutathione peroxidase 7
chr7_-_127936097 1.523 ENSMUST00000150591.1
Prss36
protease, serine, 36
chr8_+_3631109 1.484 ENSMUST00000004745.8
Stxbp2
syntaxin binding protein 2
chr11_+_78037959 1.463 ENSMUST00000073660.6
Flot2
flotillin 2
chr9_+_54538984 1.456 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr4_+_133039482 1.451 ENSMUST00000105914.1
Ahdc1
AT hook, DNA binding motif, containing 1
chr9_-_32541589 1.444 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr18_-_67449083 1.394 ENSMUST00000025408.8
Afg3l2
AFG3(ATPase family gene 3)-like 2 (yeast)
chr1_+_172341197 1.361 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr6_-_86793522 1.307 ENSMUST00000001187.8
Anxa4
annexin A4
chr4_-_124850652 1.253 ENSMUST00000125776.1
1110065P20Rik
RIKEN cDNA 1110065P20 gene
chr11_+_75513540 1.198 ENSMUST00000042808.6
ENSMUST00000118243.1
Scarf1

scavenger receptor class F, member 1

chr15_-_98567630 1.178 ENSMUST00000012104.6
Ccnt1
cyclin T1
chr1_+_36511867 1.141 ENSMUST00000001166.7
ENSMUST00000097776.3
Cnnm3

cyclin M3

chr6_+_4902913 1.124 ENSMUST00000175889.1
ENSMUST00000168998.2
Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr2_-_51934644 1.072 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr10_-_67548944 1.068 ENSMUST00000075686.4
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr9_-_63377835 1.027 ENSMUST00000034920.9
Map2k5
mitogen-activated protein kinase kinase 5
chr1_+_63176818 1.022 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr14_-_70766598 1.001 ENSMUST00000167242.1
ENSMUST00000022696.6
Xpo7

exportin 7

chr3_+_96181151 0.996 ENSMUST00000035371.8
Sv2a
synaptic vesicle glycoprotein 2 a
chr3_-_96293953 0.978 ENSMUST00000029748.3
Fcgr1
Fc receptor, IgG, high affinity I
chr7_+_44442398 0.962 ENSMUST00000058667.8
Lrrc4b
leucine rich repeat containing 4B
chr10_+_116301374 0.919 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr9_+_22003035 0.918 ENSMUST00000115331.2
ENSMUST00000003493.7
Prkcsh

protein kinase C substrate 80K-H

chr17_+_24470393 0.882 ENSMUST00000053024.6
Pgp
phosphoglycolate phosphatase
chr4_-_42084291 0.866 ENSMUST00000177937.1
Gm21968
predicted gene, 21968
chr9_+_108662098 0.860 ENSMUST00000035222.5
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr4_-_42581621 0.835 ENSMUST00000178742.1
Gm10592
predicted gene 10592
chr5_+_123076275 0.805 ENSMUST00000067505.8
ENSMUST00000111619.3
ENSMUST00000160344.1
Tmem120b


transmembrane protein 120B


chr11_+_5955693 0.761 ENSMUST00000002818.8
Ykt6
YKT6 homolog (S. Cerevisiae)
chr8_-_70510552 0.747 ENSMUST00000125184.1
Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr16_+_20535475 0.724 ENSMUST00000090023.6
ENSMUST00000007216.8
Ap2m1

adaptor-related protein complex 2, mu 1 subunit

chr2_-_120353094 0.704 ENSMUST00000028752.7
ENSMUST00000102501.3
Vps39

vacuolar protein sorting 39 (yeast)

chr6_+_4903298 0.701 ENSMUST00000035813.2
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr17_-_35909626 0.671 ENSMUST00000141132.1
Atat1
alpha tubulin acetyltransferase 1
chr17_-_35910032 0.665 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
Atat1




alpha tubulin acetyltransferase 1




chr6_-_30390997 0.657 ENSMUST00000152391.2
ENSMUST00000115184.1
ENSMUST00000080812.7
ENSMUST00000102992.3
Zc3hc1



zinc finger, C3HC type 1



chr7_+_138846579 0.656 ENSMUST00000155672.1
Ppp2r2d
protein phosphatase 2, regulatory subunit B, delta isoform
chr11_+_116198853 0.598 ENSMUST00000021130.6
Ten1
TEN1 telomerase capping complex subunit
chr12_+_86678685 0.594 ENSMUST00000021681.3
Vash1
vasohibin 1
chr2_+_91650116 0.592 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr8_-_70510322 0.585 ENSMUST00000140679.1
ENSMUST00000129909.1
ENSMUST00000081940.4
Uba52


ubiquitin A-52 residue ribosomal protein fusion product 1


chr7_-_31055594 0.574 ENSMUST00000039909.6
Fxyd1
FXYD domain-containing ion transport regulator 1
chr9_+_44107268 0.567 ENSMUST00000114821.2
ENSMUST00000114818.2
C1qtnf5

C1q and tumor necrosis factor related protein 5

chr9_-_59353430 0.564 ENSMUST00000026265.6
Bbs4
Bardet-Biedl syndrome 4 (human)
chr8_-_71043040 0.531 ENSMUST00000170101.1
Gm17576
predicted gene, 17576
chr9_+_44107286 0.507 ENSMUST00000152956.1
ENSMUST00000114815.1
C1qtnf5

C1q and tumor necrosis factor related protein 5

chr4_+_146654927 0.499 ENSMUST00000070932.3
Gm13248
predicted gene 13248
chr10_+_89686365 0.457 ENSMUST00000181598.1
1500026H17Rik
RIKEN cDNA 1500026H17 gene
chr14_-_70159433 0.448 ENSMUST00000058240.7
ENSMUST00000153871.1
9930012K11Rik

RIKEN cDNA 9930012K11 gene

chr13_+_40859768 0.427 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr15_+_86214431 0.400 ENSMUST00000063414.8
Tbc1d22a
TBC1 domain family, member 22a
chr16_-_4523056 0.391 ENSMUST00000090500.3
ENSMUST00000023161.7
Srl

sarcalumenin

chr12_-_80260356 0.327 ENSMUST00000021554.8
Actn1
actinin, alpha 1
chr4_-_133672601 0.322 ENSMUST00000062118.4
ENSMUST00000067902.6
Pigv

phosphatidylinositol glycan anchor biosynthesis, class V

chr9_-_42399709 0.310 ENSMUST00000160940.1
Tecta
tectorin alpha
chrX_+_101532734 0.292 ENSMUST00000118878.1
ENSMUST00000101341.2
ENSMUST00000149274.1
Taf1


TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor


chr5_-_140649018 0.253 ENSMUST00000042661.3
Ttyh3
tweety homolog 3 (Drosophila)
chr5_-_124531308 0.217 ENSMUST00000062153.7
Rilpl1
Rab interacting lysosomal protein-like 1
chr17_-_55915870 0.212 ENSMUST00000074828.4
Rpl21-ps6
ribosomal protein L21, pseudogene 6
chr9_+_56994932 0.205 ENSMUST00000034832.6
Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chr12_-_98577940 0.197 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr11_-_116199040 0.193 ENSMUST00000066587.5
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr15_-_77927728 0.164 ENSMUST00000174468.1
ENSMUST00000174529.1
ENSMUST00000173631.1
Txn2


thioredoxin 2


chr9_+_121710389 0.134 ENSMUST00000035113.9
Deb1
differentially expressed in B16F10 1
chr13_+_74350313 0.124 ENSMUST00000160021.1
ENSMUST00000162672.1
ENSMUST00000162376.1
Ccdc127


coiled-coil domain containing 127


chr2_+_176802233 0.111 ENSMUST00000132883.1
Gm14295
predicted gene 14295
chr2_-_176149825 0.106 ENSMUST00000109049.3
ENSMUST00000179349.1
Gm2004

predicted gene 2004

chr8_+_117257019 0.103 ENSMUST00000166750.1
Cmip
c-Maf inducing protein
chr4_+_147507600 0.102 ENSMUST00000063704.7
Gm13152
predicted gene 13152
chr2_+_176711933 0.072 ENSMUST00000108983.2
Gm14305
predicted gene 14305
chrM_+_8600 0.069 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr16_+_94370618 0.064 ENSMUST00000117648.1
ENSMUST00000147352.1
ENSMUST00000150346.1
ENSMUST00000155692.1
ENSMUST00000153988.1
ENSMUST00000141856.1
ENSMUST00000152117.1
ENSMUST00000150097.1
ENSMUST00000122895.1
ENSMUST00000151770.1
Ttc3









tetratricopeptide repeat domain 3









chr1_-_162859684 0.055 ENSMUST00000131058.1
Fmo1
flavin containing monooxygenase 1
chr5_-_24445254 0.054 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr17_+_25133385 0.051 ENSMUST00000040729.2
Clcn7
chloride channel 7
chr13_-_73678005 0.038 ENSMUST00000022105.7
ENSMUST00000109680.2
ENSMUST00000109679.2
Slc6a18


solute carrier family 6 (neurotransmitter transporter), member 18


chr2_+_177004553 0.022 ENSMUST00000126358.1
Gm14419
predicted gene 14419
chr9_-_22002599 0.020 ENSMUST00000115336.2
ENSMUST00000044926.5
Ccdc151

coiled-coil domain containing 151

chr3_+_137623672 0.017 ENSMUST00000053855.7
Ddit4l
DNA-damage-inducible transcript 4-like
chr2_-_177202829 0.002 ENSMUST00000133301.1
Gm14410
predicted gene 14410

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.3 7.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.8 5.8 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.8 5.7 GO:0010273 detoxification of copper ion(GO:0010273) cellular response to zinc ion(GO:0071294) stress response to copper ion(GO:1990169)
0.6 3.9 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.6 3.2 GO:0015871 choline transport(GO:0015871)
0.6 1.8 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.6 2.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.5 1.5 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.5 2.9 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
0.5 1.8 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.5 2.3 GO:2001025 positive regulation of response to drug(GO:2001025)
0.4 1.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.4 2.5 GO:0006172 ADP biosynthetic process(GO:0006172)
0.4 1.6 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.4 4.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.4 1.9 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.3 1.0 GO:0070375 ERK5 cascade(GO:0070375)
0.3 1.4 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.3 1.0 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.3 0.9 GO:0019401 alditol biosynthetic process(GO:0019401)
0.3 1.7 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.2 6.6 GO:0030431 sleep(GO:0030431)
0.2 1.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.2 1.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 0.7 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 0.6 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.3 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.1 0.6 GO:1903546 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) protein localization to photoreceptor outer segment(GO:1903546)
0.1 0.7 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 0.9 GO:0015879 carnitine transport(GO:0015879)
0.1 0.6 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) negative regulation of vacuolar transport(GO:1903336)
0.1 1.2 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 1.2 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.1 1.5 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.1 0.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 6.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 2.5 GO:0014047 glutamate secretion(GO:0014047)
0.1 1.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.6 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) regulation of inorganic anion transmembrane transport(GO:1903795)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 2.5 GO:0071625 vocalization behavior(GO:0071625)
0.1 0.4 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.1 1.0 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.1 1.4 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.2 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 4.7 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 2.4 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.3 GO:0030220 platelet formation(GO:0030220)
0.0 0.9 GO:0006491 N-glycan processing(GO:0006491)
0.0 5.6 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 6.6 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.7 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.8 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 1.0 GO:0045471 response to ethanol(GO:0045471)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.4 GO:0043627 response to estrogen(GO:0043627)
0.0 1.0 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.7 GO:0070206 protein trimerization(GO:0070206)
0.0 1.0 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.9 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.2 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
1.3 7.7 GO:0097512 cardiac myofibril(GO:0097512)
0.6 1.9 GO:0045160 myosin I complex(GO:0045160)
0.5 4.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 1.5 GO:0044194 cytolytic granule(GO:0044194)
0.4 2.5 GO:0097513 myosin II filament(GO:0097513)
0.4 1.8 GO:1990761 growth cone lamellipodium(GO:1990761)
0.3 1.4 GO:0005745 m-AAA complex(GO:0005745)
0.3 2.5 GO:0001520 outer dense fiber(GO:0001520)
0.2 1.8 GO:0033269 internode region of axon(GO:0033269)
0.2 1.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 0.8 GO:0097441 basilar dendrite(GO:0097441)
0.1 1.3 GO:0097427 microtubule bundle(GO:0097427)
0.1 2.3 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.4 GO:0097449 astrocyte projection(GO:0097449)
0.1 1.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 0.3 GO:0032127 dense core granule membrane(GO:0032127)
0.1 4.4 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.3 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 0.6 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.7 GO:0030123 AP-3 adaptor complex(GO:0030123) HOPS complex(GO:0030897)
0.1 4.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.6 GO:0034464 BBSome(GO:0034464)
0.0 1.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.6 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.8 GO:0005770 late endosome(GO:0005770)
0.0 2.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 8.1 GO:0098793 presynapse(GO:0098793)
0.0 7.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)
0.0 3.8 GO:0043235 receptor complex(GO:0043235)
0.0 1.7 GO:0055037 recycling endosome(GO:0055037)
0.0 2.6 GO:0030141 secretory granule(GO:0030141)
0.0 1.6 GO:0010008 endosome membrane(GO:0010008)
0.0 1.6 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.9 8.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.9 7.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.8 3.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.6 4.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.5 4.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 2.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.5 1.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.5 1.8 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.4 3.9 GO:0034711 inhibin binding(GO:0034711)
0.4 2.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.4 1.5 GO:0004096 catalase activity(GO:0004096)
0.4 1.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.3 4.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 2.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 1.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 0.9 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967)
0.2 0.9 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.2 1.0 GO:0019770 IgG receptor activity(GO:0019770)
0.2 4.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 5.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 5.7 GO:0005507 copper ion binding(GO:0005507)
0.1 1.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.3 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 1.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.6 GO:0034452 dynactin binding(GO:0034452)
0.1 1.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 1.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 1.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 2.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.6 GO:0043621 protein self-association(GO:0043621)
0.0 1.5 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.6 GO:0019894 kinesin binding(GO:0019894)
0.0 1.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0017166 vinculin binding(GO:0017166)
0.0 2.7 GO:0051117 ATPase binding(GO:0051117)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 5.1 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 9.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 7.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 4.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 5.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.9 8.9 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.6 4.4 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.4 14.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 3.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 2.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 2.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.3 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 6.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 2.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 0.9 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.2 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions