Motif ID: Nr1i3

Z-value: 1.161


Transcription factors associated with Nr1i3:

Gene SymbolEntrez IDGene Name
Nr1i3 ENSMUSG00000005677.8 Nr1i3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1i3mm10_v2_chr1_+_171213969_1712140070.122.9e-01Click!


Activity profile for motif Nr1i3.

activity profile for motif Nr1i3


Sorted Z-values histogram for motif Nr1i3

Sorted Z-values for motif Nr1i3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1i3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_25469742 9.024 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr11_+_113619318 7.351 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr11_+_61485431 6.958 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr11_-_3931960 6.785 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2




chr1_+_135729147 6.641 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr1_+_90203980 6.453 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr10_-_102490418 6.373 ENSMUST00000020040.3
 Nts
neurotensin
chr11_+_101468164 4.905 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr7_-_115846080 4.805 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr6_+_134929089 4.632 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr6_+_134929118 4.524 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr15_-_35938009 4.236 ENSMUST00000156915.1
 Cox6c
cytochrome c oxidase subunit VIc
chr2_-_25470031 4.220 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr10_+_57794335 4.110 ENSMUST00000151623.1
ENSMUST00000020022.7
 Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

chr6_-_5256226 4.087 ENSMUST00000125686.1
ENSMUST00000031773.2
 Pon3

paraoxonase 3

chr4_+_116708571 3.820 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr14_+_65806066 3.796 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr2_+_118813995 3.715 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr9_+_65587187 3.708 ENSMUST00000047099.5
ENSMUST00000131483.1
ENSMUST00000141046.1
 Pif1


PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)


chr5_+_135725713 3.661 ENSMUST00000127096.1
 Por
P450 (cytochrome) oxidoreductase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 681 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 14.8 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.8 13.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.4 12.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.3 12.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.4 11.7 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
1.0 10.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 10.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
2.4 9.8 GO:0015889 cobalamin transport(GO:0015889)
0.8 7.5 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.4 7.5 GO:0038092 nodal signaling pathway(GO:0038092)
1.0 7.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.4 7.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.6 6.9 GO:0030432 peristalsis(GO:0030432)
2.2 6.6 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 5.8 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
1.1 5.6 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.3 5.5 GO:0051451 myoblast migration(GO:0051451)
0.2 5.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.7 5.3 GO:0006004 fucose metabolic process(GO:0006004)
0.4 5.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 275 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 44.1 GO:0005615 extracellular space(GO:0005615)
0.1 24.6 GO:0005667 transcription factor complex(GO:0005667)
0.5 24.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 18.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 15.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 14.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 14.3 GO:0005739 mitochondrion(GO:0005739)
0.2 11.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 10.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 9.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 9.2 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 8.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 8.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 8.2 GO:0005657 replication fork(GO:0005657)
0.1 8.1 GO:0000922 spindle pole(GO:0000922)
0.0 7.9 GO:0005925 focal adhesion(GO:0005925)
2.3 7.0 GO:0071953 elastic fiber(GO:0071953)
0.3 7.0 GO:0005680 anaphase-promoting complex(GO:0005680)
1.1 6.6 GO:0061689 tricellular tight junction(GO:0061689)
0.4 6.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 431 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 15.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
3.3 13.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.0 10.9 GO:0008430 selenium binding(GO:0008430)
0.4 10.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.4 9.7 GO:0031419 cobalamin binding(GO:0031419)
1.5 8.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 8.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
2.9 8.7 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.3 8.4 GO:0071837 HMG box domain binding(GO:0071837)
0.2 7.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
2.5 7.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 7.5 GO:0005178 integrin binding(GO:0005178)
0.4 7.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 7.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 7.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.4 7.1 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
1.7 7.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 7.0 GO:0016209 antioxidant activity(GO:0016209)
0.4 6.6 GO:0001054 RNA polymerase I activity(GO:0001054)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 12.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 12.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 11.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 9.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 8.6 PID_ATR_PATHWAY ATR signaling pathway
0.8 7.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 7.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 6.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 6.7 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 6.3 PID_PLK1_PATHWAY PLK1 signaling events
0.1 6.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 4.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.4 PID_P73PATHWAY p73 transcription factor network
0.3 4.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 3.9 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 3.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 3.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 3.6 PID_BARD1_PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 42.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 14.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 12.0 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.4 11.2 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.2 10.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 10.1 REACTOME_AMYLOIDS Genes involved in Amyloids
0.6 9.9 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 9.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 8.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 7.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.2 7.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 7.0 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.6 6.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 6.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 6.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 5.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 5.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 5.4 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.3 5.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)