Motif ID: Nr2c1

Z-value: 0.767


Transcription factors associated with Nr2c1:

Gene SymbolEntrez IDGene Name
Nr2c1 ENSMUSG00000005897.8 Nr2c1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c1mm10_v2_chr10_+_94147982_94148023-0.394.9e-04Click!


Activity profile for motif Nr2c1.

activity profile for motif Nr2c1


Sorted Z-values histogram for motif Nr2c1

Sorted Z-values for motif Nr2c1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c1

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_29411736 10.543 ENSMUST00000115236.1
 Ntm
neurotrimin
chr9_-_29412204 9.927 ENSMUST00000115237.1
 Ntm
neurotrimin
chr15_+_80091320 9.618 ENSMUST00000009728.6
ENSMUST00000009727.5
 Syngr1

synaptogyrin 1

chr15_+_3270767 9.410 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr10_+_58813359 8.857 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr9_-_21037775 8.678 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr6_+_22875496 8.660 ENSMUST00000090568.3
 Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr4_-_46991842 7.907 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr3_+_68572245 6.972 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr11_-_76577701 6.800 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr7_+_45896941 5.840 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr11_+_75193783 5.646 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr10_-_86498836 5.606 ENSMUST00000120638.1
 Syn3
synapsin III
chr12_+_61523889 5.097 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr15_-_79505241 4.643 ENSMUST00000057801.6
 Kcnj4
potassium inwardly-rectifying channel, subfamily J, member 4
chr7_+_45897429 3.827 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr14_+_75136326 3.389 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1
chr10_-_86498872 3.296 ENSMUST00000121789.1
 Syn3
synapsin III
chr1_+_195017399 3.265 ENSMUST00000181273.1
 A330023F24Rik
RIKEN cDNA A330023F24 gene
chr1_-_155417283 3.248 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.1 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.5 9.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 8.9 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
2.9 8.7 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.3 7.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 7.3 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.4 7.0 GO:0001553 luteinization(GO:0001553)
1.4 6.8 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.3 4.9 GO:0048681 negative regulation of axon regeneration(GO:0048681)
1.5 4.6 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 4.6 GO:0010107 potassium ion import(GO:0010107)
0.1 3.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.2 3.5 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.2 3.4 GO:0051639 actin filament network formation(GO:0051639)
0.2 3.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.5 3.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.0 3.0 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.1 3.0 GO:0032060 bleb assembly(GO:0032060)
0.0 3.0 GO:0050821 protein stabilization(GO:0050821)
0.7 2.9 GO:0032275 luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 18.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
2.9 8.7 GO:0072534 perineuronal net(GO:0072534)
0.2 8.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.6 7.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 5.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 4.6 GO:0097427 microtubule bundle(GO:0097427)
0.1 4.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 3.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 3.4 GO:0001891 phagocytic cup(GO:0001891)
0.4 3.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 3.2 GO:0071565 nBAF complex(GO:0071565)
0.1 3.0 GO:1990391 DNA repair complex(GO:1990391)
0.0 3.0 GO:0005604 basement membrane(GO:0005604)
0.2 2.9 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 2.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 2.7 GO:0043198 dendritic shaft(GO:0043198)
0.1 2.5 GO:0016235 aggresome(GO:0016235)
0.0 2.2 GO:0014704 intercalated disc(GO:0014704)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.7 GO:0017134 fibroblast growth factor binding(GO:0017134)
1.3 7.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 6.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.6 5.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.8 4.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 4.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 3.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 3.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.1 3.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
1.0 3.0 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 2.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.9 2.7 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 2.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 2.4 GO:0043022 ribosome binding(GO:0043022)
0.3 2.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 2.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.1 GO:0016831 carboxy-lyase activity(GO:0016831)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 3.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 2.5 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 2.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.1 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.9 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.6 7.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 6.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 4.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 3.4 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 3.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 3.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 2.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.5 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 2.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 1.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 1.1 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.0 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription