Motif ID: Nr2c1
Z-value: 0.767
Transcription factors associated with Nr2c1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr2c1 | ENSMUSG00000005897.8 | Nr2c1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr2c1 | mm10_v2_chr10_+_94147982_94148023 | -0.39 | 4.9e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.7 | GO:1900149 | positive regulation of Schwann cell migration(GO:1900149) |
| 1.5 | 4.6 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 1.4 | 6.8 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 1.2 | 3.5 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
| 1.0 | 3.0 | GO:1902336 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
| 0.7 | 2.9 | GO:0032275 | luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278) |
| 0.7 | 2.1 | GO:0015938 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) |
| 0.7 | 2.0 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.5 | 3.2 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.5 | 1.6 | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) |
| 0.5 | 9.6 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.5 | 2.7 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.4 | 2.9 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923) |
| 0.4 | 7.0 | GO:0001553 | luteinization(GO:0001553) |
| 0.3 | 2.2 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.3 | 2.2 | GO:0098909 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.3 | 4.9 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.3 | 1.5 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.3 | 7.9 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.3 | 1.6 | GO:0014874 | response to stimulus involved in regulation of muscle adaptation(GO:0014874) |
| 0.2 | 2.2 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.2 | 3.4 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.2 | 0.5 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.2 | 2.1 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.2 | 3.3 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
| 0.2 | 0.6 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.2 | 4.6 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 3.0 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 0.9 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.1 | 1.0 | GO:0003056 | regulation of vascular smooth muscle contraction(GO:0003056) |
| 0.1 | 0.4 | GO:2000097 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.1 | 0.4 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.1 | 23.1 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.1 | 1.1 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.1 | 1.1 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 3.7 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 2.7 | GO:0031069 | hair follicle morphogenesis(GO:0031069) |
| 0.1 | 1.1 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.1 | 2.1 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 1.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 2.5 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
| 0.1 | 0.7 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 8.9 | GO:0099643 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.1 | 0.4 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.1 | 0.7 | GO:0010155 | regulation of proton transport(GO:0010155) |
| 0.1 | 0.3 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 1.6 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.1 | 0.4 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.0 | 7.3 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 0.6 | GO:0035814 | negative regulation of renal sodium excretion(GO:0035814) |
| 0.0 | 1.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 1.1 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 1.6 | GO:0097006 | regulation of plasma lipoprotein particle levels(GO:0097006) |
| 0.0 | 0.9 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 1.4 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.3 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 0.0 | 3.0 | GO:0050821 | protein stabilization(GO:0050821) |
| 0.0 | 0.3 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.7 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.6 | 7.9 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.5 | 4.6 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.4 | 3.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.3 | 1.6 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.2 | 18.5 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 8.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 2.1 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.2 | 20.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 2.9 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.2 | 3.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.2 | 2.7 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 0.6 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.1 | 3.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 3.2 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 1.1 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.1 | 0.9 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.1 | 4.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 2.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.1 | 0.4 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.1 | 2.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 1.0 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 2.1 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 3.0 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 2.5 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.2 | GO:0034715 | U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715) |
| 0.0 | 1.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.2 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 3.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 2.7 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 1.6 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 5.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.0 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.4 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.3 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 0.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.6 | GO:0016324 | apical plasma membrane(GO:0016324) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 7.9 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 1.1 | 3.2 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 1.0 | 3.0 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.9 | 2.7 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.8 | 4.6 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.6 | 5.6 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.5 | 1.5 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.3 | 2.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.3 | 1.6 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.3 | 8.7 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.2 | 4.6 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.2 | 1.4 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 2.9 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 3.3 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.1 | 1.6 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.1 | 2.1 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 0.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 2.0 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 1.5 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 1.1 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 0.4 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.1 | 1.5 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 2.1 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.7 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 0.4 | GO:0070404 | NADH binding(GO:0070404) |
| 0.1 | 1.0 | GO:0042166 | acetylcholine binding(GO:0042166) |
| 0.1 | 0.3 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.1 | 3.4 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.1 | 0.7 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.1 | 0.7 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 6.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 2.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 1.1 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 2.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 2.7 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 2.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 2.4 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.6 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 0.4 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.3 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 6.8 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 2.1 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.3 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.1 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 2.5 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 2.1 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.0 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.4 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.2 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.9 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.6 | 8.9 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.2 | 3.0 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 3.4 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.2 | 1.6 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
| 0.2 | 3.3 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 2.5 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 2.2 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 4.6 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 1.0 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 1.1 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 0.5 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.1 | 6.8 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.7 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 1.0 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 4.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.1 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.3 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 0.7 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.2 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 0.3 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.4 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
