Motif ID: Nr2e1

Z-value: 0.308


Transcription factors associated with Nr2e1:

Gene SymbolEntrez IDGene Name
Nr2e1 ENSMUSG00000019803.5 Nr2e1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2e1mm10_v2_chr10_-_42583628_425836390.113.5e-01Click!


Activity profile for motif Nr2e1.

activity profile for motif Nr2e1


Sorted Z-values histogram for motif Nr2e1

Sorted Z-values for motif Nr2e1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_33924632 2.200 ENSMUST00000057188.6
 Cnr1
cannabinoid receptor 1 (brain)
chr4_-_63403330 1.893 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chrX_-_143827391 1.783 ENSMUST00000087316.5
 Capn6
calpain 6
chr4_+_32238950 1.446 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chrX_-_139998519 1.418 ENSMUST00000113007.1
ENSMUST00000033810.7
ENSMUST00000113011.2
ENSMUST00000087400.5
 Rbm41



RNA binding motif protein 41



chr8_-_61902669 1.367 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr4_+_28813125 1.147 ENSMUST00000029964.5
ENSMUST00000080934.4
 Epha7

Eph receptor A7

chr4_+_28813152 1.128 ENSMUST00000108194.2
ENSMUST00000108191.1
 Epha7

Eph receptor A7

chr15_-_10485385 1.107 ENSMUST00000168690.1
 Brix1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chr4_-_35845204 1.049 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr5_-_88527841 0.978 ENSMUST00000087033.3
 Igj
immunoglobulin joining chain
chr15_-_10485890 0.937 ENSMUST00000169050.1
ENSMUST00000022855.5
 Brix1

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)

chr4_-_119415494 0.833 ENSMUST00000063642.2
 Ccdc30
coiled-coil domain containing 30
chr2_-_73386396 0.766 ENSMUST00000112044.1
ENSMUST00000112043.1
ENSMUST00000076463.5
 Gpr155


G protein-coupled receptor 155


chr12_+_111166485 0.691 ENSMUST00000139162.1
 Traf3
TNF receptor-associated factor 3
chr12_+_111166413 0.659 ENSMUST00000021706.4
 Traf3
TNF receptor-associated factor 3
chr12_+_111166349 0.555 ENSMUST00000117269.1
 Traf3
TNF receptor-associated factor 3
chr12_+_111166536 0.491 ENSMUST00000060274.6
 Traf3
TNF receptor-associated factor 3
chr6_-_126939524 0.432 ENSMUST00000144954.1
ENSMUST00000112221.1
ENSMUST00000112220.1
 Rad51ap1


RAD51 associated protein 1


chr2_-_23040137 0.406 ENSMUST00000091394.6
ENSMUST00000093171.6
 Abi1

abl-interactor 1

chrX_-_95658392 0.383 ENSMUST00000120620.1
 Zc4h2
zinc finger, C4H2 domain containing
chr2_-_23040177 0.381 ENSMUST00000114544.3
ENSMUST00000139038.1
ENSMUST00000126112.1
ENSMUST00000178908.1
ENSMUST00000078977.7
ENSMUST00000140164.1
ENSMUST00000149719.1
 Abi1






abl-interactor 1






chrX_-_95658379 0.316 ENSMUST00000119640.1
 Zc4h2
zinc finger, C4H2 domain containing
chr1_-_53785214 0.307 ENSMUST00000027263.7
 Stk17b
serine/threonine kinase 17b (apoptosis-inducing)
chrM_+_7005 0.301 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr17_+_32685655 0.299 ENSMUST00000008801.6
 Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chr3_+_14578609 0.292 ENSMUST00000029069.6
ENSMUST00000165922.2
 E2f5

E2F transcription factor 5

chr10_+_18469958 0.282 ENSMUST00000162891.1
ENSMUST00000100054.3
 Nhsl1

NHS-like 1

chr10_-_61784014 0.281 ENSMUST00000020283.4
 H2afy2
H2A histone family, member Y2
chrX_-_95658416 0.264 ENSMUST00000044382.6
 Zc4h2
zinc finger, C4H2 domain containing
chr2_-_23040092 0.254 ENSMUST00000153931.1
ENSMUST00000123948.1
 Abi1

abl-interactor 1

chr15_-_97705787 0.216 ENSMUST00000023104.5
 Rpap3
RNA polymerase II associated protein 3
chr15_+_41830921 0.215 ENSMUST00000166917.1
 Oxr1
oxidation resistance 1
chr6_+_126939957 0.110 ENSMUST00000032497.3
 D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed
chr17_+_32685610 0.107 ENSMUST00000168171.1
 Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chr7_+_78895903 0.102 ENSMUST00000107425.1
ENSMUST00000107421.1
ENSMUST00000107423.1
 Aen


apoptosis enhancing nuclease


chr9_-_42457594 0.061 ENSMUST00000125995.1
 Tbcel
tubulin folding cofactor E-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0031622 positive regulation of fever generation(GO:0031622) trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.4 2.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.2 2.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 1.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 2.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.3 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.3 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 1.0 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.3 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.0 1.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 1.4 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)
0.0 1.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 2.4 GO:0031996 thioesterase binding(GO:0031996)
0.1 1.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 1.4 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 1.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 2.2 GO:0008144 drug binding(GO:0008144)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 2.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 2.2 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1