Motif ID: Nr2f1_Nr4a1

Z-value: 0.584

Transcription factors associated with Nr2f1_Nr4a1:

Gene SymbolEntrez IDGene Name
Nr2f1 ENSMUSG00000069171.7 Nr2f1
Nr4a1 ENSMUSG00000023034.6 Nr4a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a1mm10_v2_chr15_+_101266839_101266859-0.161.7e-01Click!
Nr2f1mm10_v2_chr13_-_78199757_78199855-0.152.1e-01Click!


Activity profile for motif Nr2f1_Nr4a1.

activity profile for motif Nr2f1_Nr4a1


Sorted Z-values histogram for motif Nr2f1_Nr4a1

Sorted Z-values for motif Nr2f1_Nr4a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f1_Nr4a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_106656081 4.970 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr1_-_164458345 3.554 ENSMUST00000027863.7
 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr5_+_63649335 3.400 ENSMUST00000159584.1
 3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr13_+_94875600 2.900 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr8_-_105471481 2.884 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr15_-_79804717 2.867 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr2_+_126556128 2.864 ENSMUST00000141482.2
 Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
chr12_+_61523889 2.743 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr2_+_71981184 2.742 ENSMUST00000090826.5
ENSMUST00000102698.3
 Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

chr11_+_7063423 2.505 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr6_+_91157373 2.438 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr17_+_29360923 2.395 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr11_-_3504766 2.147 ENSMUST00000044507.5
 Inpp5j
inositol polyphosphate 5-phosphatase J
chr11_-_76577701 2.133 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr6_+_91156772 2.101 ENSMUST00000143621.1
 Hdac11
histone deacetylase 11
chr10_+_78574492 2.091 ENSMUST00000105384.3
 Ilvbl
ilvB (bacterial acetolactate synthase)-like
chr10_-_78464969 1.987 ENSMUST00000041616.8
 Pdxk
pyridoxal (pyridoxine, vitamin B6) kinase
chr9_-_70141484 1.971 ENSMUST00000034749.8
 Fam81a
family with sequence similarity 81, member A
chr6_+_91156665 1.959 ENSMUST00000041736.4
 Hdac11
histone deacetylase 11
chr17_+_43952999 1.911 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 268 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.5 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 4.7 GO:0014047 glutamate secretion(GO:0014047)
0.2 4.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 4.2 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 4.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 4.0 GO:0071277 cellular response to calcium ion(GO:0071277)
1.3 3.9 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
1.3 3.8 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 3.6 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.4 3.0 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 3.0 GO:0046785 microtubule polymerization(GO:0046785)
1.0 2.9 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.3 2.8 GO:0071420 cellular response to histamine(GO:0071420)
0.3 2.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.7 2.7 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.2 2.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 2.5 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.3 2.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 2.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 2.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.1 5.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 5.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.5 4.5 GO:0097427 microtubule bundle(GO:0097427)
0.3 4.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.5 3.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 3.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.6 GO:0043204 perikaryon(GO:0043204)
0.0 3.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.4 GO:0005930 axoneme(GO:0005930)
0.2 3.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 2.8 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.5 2.7 GO:0044316 cone cell pedicle(GO:0044316)
0.1 2.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.3 2.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 2.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.6 1.9 GO:0098855 HCN channel complex(GO:0098855)
0.5 1.9 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 1.9 GO:0009986 cell surface(GO:0009986)
0.1 1.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.3 6.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 5.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 5.1 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
1.0 5.0 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.3 4.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.3 3.9 GO:0031403 lithium ion binding(GO:0031403)
0.9 3.5 GO:0004111 creatine kinase activity(GO:0004111)
0.2 3.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 3.1 GO:0051082 unfolded protein binding(GO:0051082)
0.3 3.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.0 GO:0030552 cAMP binding(GO:0030552)
0.7 2.9 GO:0001847 opsonin receptor activity(GO:0001847)
0.0 2.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.3 2.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 2.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.7 2.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.4 2.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 2.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 2.0 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 5.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 4.6 PID_FOXO_PATHWAY FoxO family signaling
0.0 4.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 2.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 2.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.9 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.4 PID_ARF_3PATHWAY Arf1 pathway
0.1 1.1 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.8 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 8.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 5.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 5.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 5.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 4.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 4.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 3.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.5 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.4 3.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 3.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 3.1 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.2 3.0 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 2.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.4 1.9 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.9 REACTOME_TRANSLATION Genes involved in Translation
0.1 1.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane