Motif ID: Nr2f2

Z-value: 0.803


Transcription factors associated with Nr2f2:

Gene SymbolEntrez IDGene Name
Nr2f2 ENSMUSG00000030551.7 Nr2f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f2mm10_v2_chr7_-_70366735_70366771-0.216.9e-02Click!


Activity profile for motif Nr2f2.

activity profile for motif Nr2f2


Sorted Z-values histogram for motif Nr2f2

Sorted Z-values for motif Nr2f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_98053415 9.268 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr11_+_50602072 4.187 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr5_-_71658308 3.815 ENSMUST00000031121.5
 Gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr3_-_116712198 3.398 ENSMUST00000120120.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr7_+_48959089 3.172 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chr3_+_121723515 3.141 ENSMUST00000029771.8
 F3
coagulation factor III
chr9_+_51765325 3.046 ENSMUST00000065496.5
 Arhgap20
Rho GTPase activating protein 20
chr13_-_96132568 3.029 ENSMUST00000161263.1
 Sv2c
synaptic vesicle glycoprotein 2c
chr3_-_116711820 2.953 ENSMUST00000153108.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr7_+_130865835 2.926 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr7_-_79386943 2.836 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr3_-_85746266 2.661 ENSMUST00000118408.1
 Fam160a1
family with sequence similarity 160, member A1
chr5_+_64803513 2.538 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr2_+_130406478 2.272 ENSMUST00000055421.4
 Tmem239
transmembrane 239
chrX_-_85776606 2.269 ENSMUST00000142152.1
ENSMUST00000156390.1
ENSMUST00000113978.2
 Gyk


glycerol kinase


chr5_-_107869153 2.249 ENSMUST00000128723.1
ENSMUST00000124034.1
 Evi5

ecotropic viral integration site 5

chr14_-_102982630 2.213 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr3_-_132950043 2.168 ENSMUST00000117164.1
ENSMUST00000093971.4
ENSMUST00000042729.9
ENSMUST00000042744.9
ENSMUST00000117811.1
 Npnt




nephronectin




chr19_+_37550397 2.141 ENSMUST00000066439.6
 Exoc6
exocyst complex component 6
chrX_+_42067836 2.130 ENSMUST00000115094.1
 Xiap
X-linked inhibitor of apoptosis

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 8.2 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.3 6.0 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.1 4.5 GO:0051453 regulation of intracellular pH(GO:0051453)
0.2 4.2 GO:0030574 collagen catabolic process(GO:0030574)
0.5 3.8 GO:2001023 regulation of response to drug(GO:2001023)
1.1 3.4 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.5 3.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.8 3.2 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
1.0 3.1 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
0.0 3.1 GO:0007601 visual perception(GO:0007601)
0.6 2.9 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.2 2.9 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 2.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 2.8 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.1 2.7 GO:0034453 microtubule anchoring(GO:0034453)
0.2 2.6 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 2.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.6 GO:0061512 protein localization to cilium(GO:0061512)
0.3 2.5 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 2.5 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 4.9 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.1 4.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 4.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 4.0 GO:0031901 early endosome membrane(GO:0031901)
0.3 3.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 3.5 GO:0031985 Golgi cisterna(GO:0031985)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 3.2 GO:0005614 interstitial matrix(GO:0005614)
0.4 2.6 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 2.4 GO:0000242 pericentriolar material(GO:0000242)
0.4 2.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 2.1 GO:0000145 exocyst(GO:0000145)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.1 GO:0005811 lipid particle(GO:0005811)
0.0 2.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 2.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.5 1.9 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.4 1.7 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.2 1.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.2 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 7.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 6.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.8 GO:0005509 calcium ion binding(GO:0005509)
0.5 5.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 4.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 3.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 3.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 3.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 3.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.2 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 3.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.5 2.8 GO:0019841 retinol binding(GO:0019841)
0.1 2.6 GO:0005109 frizzled binding(GO:0005109)
0.3 2.5 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 2.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 2.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.5 2.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.5 1.9 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 3.3 PID_INSULIN_PATHWAY Insulin Pathway
0.0 3.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.1 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 2.0 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 1.5 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.2 1.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.9 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 0.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 5.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 4.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 3.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 3.8 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1 3.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 3.2 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 2.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.4 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.7 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 1.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 1.5 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.3 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes