Motif ID: Nr2f6

Z-value: 0.937


Transcription factors associated with Nr2f6:

Gene SymbolEntrez IDGene Name
Nr2f6 ENSMUSG00000002393.8 Nr2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f6mm10_v2_chr8_-_71381907_713819770.252.6e-02Click!


Activity profile for motif Nr2f6.

activity profile for motif Nr2f6


Sorted Z-values histogram for motif Nr2f6

Sorted Z-values for motif Nr2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 131 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_121967822 14.418 ENSMUST00000137089.1
 Arhgap29
Rho GTPase activating protein 29
chr19_-_12501996 13.681 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr12_+_74288735 12.051 ENSMUST00000095617.1
 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr11_+_32283511 10.441 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chr9_+_109051153 8.982 ENSMUST00000155541.1
ENSMUST00000120305.1
ENSMUST00000154113.1
ENSMUST00000128976.1
ENSMUST00000135942.1
ENSMUST00000143754.1
 Shisa5





shisa homolog 5 (Xenopus laevis)





chr4_+_85205120 8.914 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr7_+_45896941 8.701 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr4_+_85205417 8.456 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr15_-_95528702 7.950 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr6_+_83156401 6.871 ENSMUST00000032106.4
 1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr7_+_45897429 6.566 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr8_+_71469186 6.500 ENSMUST00000124745.1
ENSMUST00000138892.1
ENSMUST00000147642.1
 Dda1


DET1 and DDB1 associated 1


chr9_+_20868628 6.207 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr10_-_35711891 5.989 ENSMUST00000080898.2
 Amd2
S-adenosylmethionine decarboxylase 2
chr19_-_21472552 5.595 ENSMUST00000087600.3
 Gda
guanine deaminase
chr7_+_98494222 5.150 ENSMUST00000165205.1
 Lrrc32
leucine rich repeat containing 32
chr2_+_25242929 5.074 ENSMUST00000114355.1
ENSMUST00000060818.1
 Rnf208

ring finger protein 208

chr13_-_92131494 4.985 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr9_-_86695897 4.855 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_+_59160838 4.854 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 17.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 17.3 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 12.4 GO:0007219 Notch signaling pathway(GO:0007219)
1.3 10.4 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.9 9.8 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
1.0 9.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 9.0 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.5 8.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 7.6 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 6.5 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032434)
0.0 6.5 GO:0032259 methylation(GO:0032259)
2.1 6.4 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 6.2 GO:0034340 response to type I interferon(GO:0034340)
2.0 6.0 GO:0006597 spermine biosynthetic process(GO:0006597)
1.9 5.6 GO:0046098 guanine metabolic process(GO:0046098)
0.1 5.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6 5.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 5.0 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
1.0 4.9 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 4.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.5 GO:0005739 mitochondrion(GO:0005739)
0.1 17.4 GO:0005769 early endosome(GO:0005769)
2.6 10.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 9.0 GO:0005635 nuclear envelope(GO:0005635)
0.1 8.0 GO:0043204 perikaryon(GO:0043204)
0.7 6.4 GO:0097427 microtubule bundle(GO:0097427)
2.0 6.0 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.6 5.6 GO:0061574 ASAP complex(GO:0061574)
0.1 5.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 4.9 GO:0030057 desmosome(GO:0030057)
0.1 4.5 GO:0060170 ciliary membrane(GO:0060170)
0.1 4.5 GO:0097440 apical dendrite(GO:0097440)
0.0 4.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 3.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 3.3 GO:0005643 nuclear pore(GO:0005643)
0.2 3.2 GO:0005686 U2 snRNP(GO:0005686)
0.5 2.4 GO:0070826 paraferritin complex(GO:0070826)
0.5 2.4 GO:0005882 intermediate filament(GO:0005882)
0.2 2.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 2.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 10.6 GO:0008289 lipid binding(GO:0008289)
2.6 10.4 GO:0031720 haptoglobin binding(GO:0031720)
0.2 9.0 GO:0050699 WW domain binding(GO:0050699)
0.0 8.4 GO:0008168 methyltransferase activity(GO:0008168)
0.1 8.0 GO:0005080 protein kinase C binding(GO:0005080)
1.1 6.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.5 6.0 GO:0019808 polyamine binding(GO:0019808)
0.2 5.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 5.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 5.0 GO:0005516 calmodulin binding(GO:0005516)
1.6 4.9 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.5 4.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
1.1 4.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.5 3.5 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 3.4 GO:0045182 translation regulator activity(GO:0045182)
0.3 3.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 3.0 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.2 2.9 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 2.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 5.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 5.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 5.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 3.4 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.1 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 17.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 14.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 13.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 9.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.5 5.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 5.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 5.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 4.7 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.3 4.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 3.6 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.3 3.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 3.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 3.0 REACTOME_TRANSLATION Genes involved in Translation
0.3 2.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.7 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 1.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.4 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport