Motif ID: Nr4a2
Z-value: 0.722

Transcription factors associated with Nr4a2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nr4a2 | ENSMUSG00000026826.7 | Nr4a2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nr4a2 | mm10_v2_chr2_-_57124003_57124071 | 0.70 | 9.0e-13 | Click! |
Top targets:
Showing 1 to 20 of 109 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 56 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 8.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
2.0 | 8.2 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
0.5 | 7.5 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
1.9 | 5.8 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
0.6 | 5.2 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
0.5 | 4.9 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
0.1 | 4.8 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
0.4 | 4.2 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
0.1 | 4.1 | GO:0014047 | glutamate secretion(GO:0014047) |
0.1 | 3.8 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
0.7 | 3.7 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
0.4 | 3.6 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
0.2 | 3.3 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
0.1 | 3.3 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.3 | 3.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.2 | 2.7 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
0.5 | 2.1 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.1 | 2.1 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
0.7 | 2.0 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
0.4 | 1.8 | GO:0010796 | regulation of multivesicular body size(GO:0010796) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 24 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 8.2 | GO:0042627 | chylomicron(GO:0042627) |
0.1 | 7.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.2 | 7.5 | GO:0043034 | costamere(GO:0043034) |
0.2 | 5.8 | GO:0035861 | site of double-strand break(GO:0035861) |
0.3 | 5.2 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
0.0 | 5.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
0.0 | 4.8 | GO:0005875 | microtubule associated complex(GO:0005875) |
0.1 | 4.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.4 | 3.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 3.3 | GO:0043679 | axon terminus(GO:0043679) |
0.0 | 2.5 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
0.3 | 1.8 | GO:0005828 | kinetochore microtubule(GO:0005828) |
0.2 | 1.8 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.1 | 1.7 | GO:0030057 | desmosome(GO:0030057) |
0.2 | 1.6 | GO:0097427 | microtubule bundle(GO:0097427) |
0.0 | 0.8 | GO:0005811 | lipid particle(GO:0005811) |
0.1 | 0.7 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
0.0 | 0.6 | GO:0005930 | axoneme(GO:0005930) |
0.1 | 0.5 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
0.0 | 0.5 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 45 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 8.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.7 | 7.5 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.1 | 7.4 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.5 | 5.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.0 | 5.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
0.8 | 4.1 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
0.1 | 4.1 | GO:0005518 | collagen binding(GO:0005518) |
0.6 | 3.8 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
0.7 | 3.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.5 | 3.4 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.0 | 3.4 | GO:0004857 | enzyme inhibitor activity(GO:0004857) |
0.1 | 3.3 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
0.0 | 3.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 2.9 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
0.1 | 2.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.0 | 2.2 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
0.5 | 2.1 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.5 | 2.0 | GO:0019808 | polyamine binding(GO:0019808) |
0.2 | 1.8 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.1 | 1.8 | GO:0031489 | myosin V binding(GO:0031489) |
Gene overrepresentation in C2:CP category:
Showing 1 to 13 of 13 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 5.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.1 | 5.8 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
0.1 | 4.2 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
0.1 | 3.8 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 2.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 2.1 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.1 | 1.8 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.1 | 1.8 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
0.0 | 1.7 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
0.0 | 1.1 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
0.0 | 0.5 | PID_MYC_PATHWAY | C-MYC pathway |
0.0 | 0.4 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
0.0 | 0.3 | PID_ARF_3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 26 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 8.2 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.1 | 7.4 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.1 | 6.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.3 | 5.8 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
0.3 | 4.1 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.3 | 3.3 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
0.1 | 3.3 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
0.1 | 3.2 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.2 | 2.5 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
0.1 | 2.5 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
0.1 | 2.1 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.1 | 1.8 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
0.1 | 1.7 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.5 | 1.4 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.1 | 1.4 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.0 | 1.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.0 | 0.9 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
0.0 | 0.7 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
0.0 | 0.6 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.0 | 0.6 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |