Motif ID: Nr4a2

Z-value: 0.722


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57124003_571240710.709.0e-13Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_68880491 8.186 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr10_+_26229707 7.113 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr18_+_86711059 6.996 ENSMUST00000068423.3
 Cbln2
cerebellin 2 precursor protein
chr5_+_150259922 4.902 ENSMUST00000087204.5
 Fry
furry homolog (Drosophila)
chr2_+_121295437 4.836 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr1_-_87573825 4.174 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr9_-_106656081 4.055 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr13_+_93303757 4.015 ENSMUST00000109494.1
 Homer1
homer homolog 1 (Drosophila)
chr1_-_124045247 3.785 ENSMUST00000112603.2
 Dpp10
dipeptidylpeptidase 10
chr9_-_32344237 3.699 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr6_-_99096196 3.571 ENSMUST00000175886.1
 Foxp1
forkhead box P1
chr13_+_93304066 3.503 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr2_-_129699833 3.261 ENSMUST00000028883.5
 Pdyn
prodynorphin
chr6_-_59024470 3.165 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr6_-_59024340 3.120 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr4_+_102760294 2.759 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
 Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr13_+_94875600 2.701 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr6_-_138422898 2.680 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3


chr5_+_63649335 2.661 ENSMUST00000159584.1
 3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr6_+_96113146 2.654 ENSMUST00000122120.1
 Fam19a1
family with sequence similarity 19, member A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
2.0 8.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.5 7.5 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
1.9 5.8 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.6 5.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.5 4.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 4.8 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.4 4.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 4.1 GO:0014047 glutamate secretion(GO:0014047)
0.1 3.8 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.7 3.7 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.4 3.6 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.2 3.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 3.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.3 3.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 2.7 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.5 2.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 2.1 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.7 2.0 GO:0006597 spermine biosynthetic process(GO:0006597)
0.4 1.8 GO:0010796 regulation of multivesicular body size(GO:0010796)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.2 GO:0042627 chylomicron(GO:0042627)
0.1 7.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 7.5 GO:0043034 costamere(GO:0043034)
0.2 5.8 GO:0035861 site of double-strand break(GO:0035861)
0.3 5.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 5.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 4.8 GO:0005875 microtubule associated complex(GO:0005875)
0.1 4.1 GO:0042734 presynaptic membrane(GO:0042734)
0.4 3.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 3.3 GO:0043679 axon terminus(GO:0043679)
0.0 2.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.3 1.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 1.8 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.7 GO:0030057 desmosome(GO:0030057)
0.2 1.6 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.1 0.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.6 GO:0005930 axoneme(GO:0005930)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.7 7.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 7.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.5 5.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 5.5 GO:0017124 SH3 domain binding(GO:0017124)
0.8 4.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 4.1 GO:0005518 collagen binding(GO:0005518)
0.6 3.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.7 3.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 3.4 GO:0001515 opioid peptide activity(GO:0001515)
0.0 3.4 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 3.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 3.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 2.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.5 2.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.5 2.0 GO:0019808 polyamine binding(GO:0019808)
0.2 1.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.8 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.8 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 4.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 7.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 6.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 5.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 4.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 3.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 3.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 3.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 2.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 2.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.1 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.8 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.5 1.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)