Motif ID: Nr4a3
Z-value: 0.670
Transcription factors associated with Nr4a3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr4a3 | ENSMUSG00000028341.3 | Nr4a3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr4a3 | mm10_v2_chr4_+_48045144_48045160 | 0.41 | 2.3e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.8 | 6.7 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.5 | 14.3 | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060) |
| 0.5 | 1.4 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.5 | 1.4 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.4 | 1.3 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.4 | 3.4 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.4 | 1.2 | GO:0050787 | glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) |
| 0.3 | 2.7 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.3 | 1.3 | GO:2000974 | negative regulation of pro-B cell differentiation(GO:2000974) |
| 0.3 | 3.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 1.8 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.3 | 1.3 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) |
| 0.3 | 0.8 | GO:2000331 | regulation of terminal button organization(GO:2000331) |
| 0.2 | 2.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.2 | 0.7 | GO:0015786 | UDP-glucose transport(GO:0015786) |
| 0.2 | 0.7 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.2 | 4.3 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.1 | 0.8 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 1.7 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.1 | 0.6 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.1 | 2.0 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.1 | 1.6 | GO:0010155 | regulation of proton transport(GO:0010155) |
| 0.1 | 1.7 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 1.4 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.1 | 0.5 | GO:0006680 | glucosylceramide catabolic process(GO:0006680) |
| 0.1 | 1.0 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.1 | 0.5 | GO:1902947 | regulation of tau-protein kinase activity(GO:1902947) |
| 0.1 | 2.4 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.1 | 0.9 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.1 | 0.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.1 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 10.4 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 2.6 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 0.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.8 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 1.7 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.0 | 0.5 | GO:0035814 | negative regulation of renal sodium excretion(GO:0035814) |
| 0.0 | 2.4 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.8 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 0.4 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.0 | 0.7 | GO:0001707 | mesoderm formation(GO:0001707) |
| 0.0 | 0.2 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.9 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.3 | 4.4 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.3 | 1.4 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.3 | 2.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.2 | 3.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.2 | 1.7 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.2 | 2.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 2.4 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 1.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 0.5 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.1 | 4.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 0.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 1.0 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 1.0 | GO:0016342 | catenin complex(GO:0016342) |
| 0.1 | 1.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 1.8 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.1 | 0.8 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 2.0 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.7 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.6 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 6.7 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.9 | 3.5 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.5 | 3.4 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.5 | 2.9 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.4 | 1.2 | GO:0036470 | tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) |
| 0.3 | 2.7 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.3 | 2.0 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.3 | 1.7 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 0.3 | 0.8 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.2 | 1.7 | GO:0015288 | porin activity(GO:0015288) |
| 0.2 | 2.4 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.2 | 3.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 1.6 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.2 | 0.5 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.1 | 3.2 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 1.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 4.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 1.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 0.8 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 1.0 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 1.7 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 1.2 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.1 | 0.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 1.8 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.8 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.9 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 1.0 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 0.2 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.0 | 0.1 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.0 | 0.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 0.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 1.1 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 1.2 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.0 | 5.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 9.4 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 0.0 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.0 | 0.0 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.0 | 0.7 | GO:0016651 | oxidoreductase activity, acting on NAD(P)H(GO:0016651) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.2 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.7 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 2.3 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 1.3 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.5 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.0 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.2 | 1.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.2 | 3.4 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 1.1 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 5.1 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.0 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.8 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.6 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 3.1 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 2.4 | REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.0 | 1.6 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.4 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.8 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 1.7 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.5 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
