Motif ID: Nr4a3

Z-value: 0.670


Transcription factors associated with Nr4a3:

Gene SymbolEntrez IDGene Name
Nr4a3 ENSMUSG00000028341.3 Nr4a3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48045144_480451600.412.3e-04Click!


Activity profile for motif Nr4a3.

activity profile for motif Nr4a3


Sorted Z-values histogram for motif Nr4a3

Sorted Z-values for motif Nr4a3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a3

PNG image of the network

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Top targets:


Showing 1 to 20 of 102 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_124793013 7.286 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 6.997 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr5_+_66968559 6.085 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chrY_-_1245685 6.021 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr5_+_66968416 5.185 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr11_-_55033398 4.348 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr15_-_79804717 3.518 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr4_+_99955715 3.381 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chrY_-_1245753 3.299 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr7_-_98162318 3.137 ENSMUST00000107112.1
 Capn5
calpain 5
chr6_-_113531575 2.700 ENSMUST00000032425.5
 Emc3
ER membrane protein complex subunit 3
chr6_-_138426735 2.555 ENSMUST00000162932.1
 Lmo3
LIM domain only 3
chr7_+_45896941 2.421 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr2_+_59160838 2.354 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4


chr5_+_111581422 2.233 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr7_+_45897429 2.052 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr3_-_59210881 2.032 ENSMUST00000040622.1
 P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr2_+_92375306 1.836 ENSMUST00000028650.8
 Pex16
peroxisomal biogenesis factor 16
chr10_-_20725023 1.789 ENSMUST00000020165.7
 Pde7b
phosphodiesterase 7B
chr7_-_19715395 1.696 ENSMUST00000032555.9
ENSMUST00000093552.5
 Tomm40

translocase of outer mitochondrial membrane 40 homolog (yeast)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 10.4 GO:0031032 actomyosin structure organization(GO:0031032)
0.8 6.7 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 4.3 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.4 3.4 GO:0019388 galactose catabolic process(GO:0019388)
0.3 3.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.0 2.9 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.3 2.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 2.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 2.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 2.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 2.0 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.3 1.8 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.1 1.7 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.7 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 1.6 GO:0010155 regulation of proton transport(GO:0010155)
0.5 1.4 GO:0098886 modification of dendritic spine(GO:0098886)
0.5 1.4 GO:0045204 MAPK export from nucleus(GO:0045204)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 4.3 GO:0031902 late endosome membrane(GO:0031902)
0.2 3.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 2.9 GO:0097427 microtubule bundle(GO:0097427)
0.2 2.4 GO:0030057 desmosome(GO:0030057)
0.2 2.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 2.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 2.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.2 1.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.3 1.4 GO:0097444 spine apparatus(GO:0097444)
0.1 1.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.0 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 1.0 GO:0016342 catenin complex(GO:0016342)
0.1 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0008270 zinc ion binding(GO:0008270)
1.0 6.7 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 5.8 GO:0003779 actin binding(GO:0003779)
0.1 4.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.9 3.5 GO:0001847 opsonin receptor activity(GO:0001847)
0.5 3.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 3.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 3.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5 2.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3 2.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 2.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 2.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 1.7 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.2 1.7 GO:0015288 porin activity(GO:0015288)
0.1 1.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 1.6 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 1.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.4 1.2 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.3 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 3.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 3.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.4 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.2 2.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.8 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 1.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 1.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.1 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.0 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.9 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac