Motif ID: Nr5a2

Z-value: 0.850


Transcription factors associated with Nr5a2:

Gene SymbolEntrez IDGene Name
Nr5a2 ENSMUSG00000026398.8 Nr5a2



Activity profile for motif Nr5a2.

activity profile for motif Nr5a2


Sorted Z-values histogram for motif Nr5a2

Sorted Z-values for motif Nr5a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr5a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_77347816 6.467 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr10_+_79716588 5.654 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr9_-_77347787 5.530 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr9_-_77347889 4.646 ENSMUST00000185039.1
 Mlip
muscular LMNA-interacting protein
chr2_+_121357714 4.474 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr19_+_6399857 4.321 ENSMUST00000146601.1
ENSMUST00000150713.1
 Rasgrp2

RAS, guanyl releasing protein 2

chr15_+_3270767 4.295 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr8_+_124793013 4.114 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr11_-_4704334 4.046 ENSMUST00000058407.5
 Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr8_+_124793061 3.969 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr2_-_73911323 3.857 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr15_-_79804717 3.841 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr2_+_121358591 3.668 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr19_+_6400523 3.620 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr11_+_98741805 3.576 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr16_+_18776839 3.513 ENSMUST00000043577.1
 Cldn5
claudin 5
chr1_-_134235420 3.363 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr3_-_54915867 3.135 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr19_+_6399746 3.091 ENSMUST00000113468.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr7_-_110862944 3.023 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 9.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 8.1 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.3 7.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 7.3 GO:0009060 aerobic respiration(GO:0009060)
0.8 6.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 6.7 GO:0006334 nucleosome assembly(GO:0006334)
0.6 5.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.0 5.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
1.1 5.7 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.0 5.0 GO:0030041 actin filament polymerization(GO:0030041)
0.0 4.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 4.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 4.3 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 4.2 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.4 4.0 GO:1990845 adaptive thermogenesis(GO:1990845)
0.2 4.0 GO:0000338 protein deneddylation(GO:0000338)
0.0 4.0 GO:0032091 negative regulation of protein binding(GO:0032091)
1.3 3.9 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
1.2 3.6 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.1 GO:0016605 PML body(GO:0016605)
0.1 14.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 9.7 GO:0044455 mitochondrial membrane part(GO:0044455)
0.8 8.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.6 8.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.7 7.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 7.5 GO:0043209 myelin sheath(GO:0043209)
0.1 7.1 GO:0000786 nucleosome(GO:0000786)
0.1 6.9 GO:0005604 basement membrane(GO:0005604)
0.1 6.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.7 6.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 5.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.9 5.7 GO:0098855 HCN channel complex(GO:0098855)
0.3 4.9 GO:0072546 ER membrane protein complex(GO:0072546)
0.5 4.8 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.1 4.0 GO:0008180 COP9 signalosome(GO:0008180)
0.2 3.5 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 3.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.1 GO:0005884 actin filament(GO:0005884)
0.1 3.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 11.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.6 10.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 10.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
2.2 8.9 GO:0004111 creatine kinase activity(GO:0004111)
0.1 7.6 GO:0005518 collagen binding(GO:0005518)
0.7 5.9 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 5.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.4 5.7 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 4.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.6 4.3 GO:0015288 porin activity(GO:0015288)
0.4 4.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.0 4.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.6 3.9 GO:0016018 cyclosporin A binding(GO:0016018)
1.0 3.8 GO:0001847 opsonin receptor activity(GO:0001847)
0.2 3.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 3.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
1.2 3.6 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.2 3.5 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.5 3.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 4.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 3.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.5 PID_INSULIN_PATHWAY Insulin Pathway
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 1.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.4 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.1 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 1.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.6 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 36.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 12.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 8.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 6.5 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 5.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.7 5.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 4.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.3 3.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 3.4 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.7 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 2.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 2.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 2.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.9 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane