Motif ID: Nrf1

Z-value: 3.624


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.638.0e-10Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_8690399 21.305 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr15_+_88751649 20.584 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr2_+_168081004 19.694 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr2_-_157007039 17.189 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr4_+_59581563 16.671 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr4_+_59581645 16.143 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr2_-_157007015 15.127 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr2_-_172370506 15.114 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr9_-_22389113 14.518 ENSMUST00000040912.7
 Anln
anillin, actin binding protein
chr6_+_66535390 14.328 ENSMUST00000116605.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr10_+_79682304 14.101 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr17_-_53689266 13.969 ENSMUST00000024736.7
 Sgol1
shugoshin-like 1 (S. pombe)
chr11_-_40733373 13.594 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr6_+_66535418 13.327 ENSMUST00000101343.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr19_-_5912834 13.203 ENSMUST00000136983.1
 Dpf2
D4, zinc and double PHD fingers family 2
chr11_-_84068357 13.113 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr5_+_36484578 12.943 ENSMUST00000060100.1
 Ccdc96
coiled-coil domain containing 96
chr13_-_53286052 12.607 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr1_-_24005608 12.488 ENSMUST00000027338.3
 1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr11_+_78094682 12.483 ENSMUST00000100782.3
 Fam222b
family with sequence similarity 222, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 610 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 42.3 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
1.1 34.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
8.3 33.4 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
1.1 31.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
10.4 31.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
4.1 24.8 GO:0003383 apical constriction(GO:0003383)
2.9 23.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
1.9 23.1 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
5.7 22.9 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
1.1 19.4 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
3.7 18.5 GO:0007403 glial cell fate determination(GO:0007403)
1.9 18.5 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
3.0 18.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
3.6 17.9 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.9 17.1 GO:0043968 histone H2A acetylation(GO:0043968)
2.4 17.0 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
3.3 16.7 GO:0034421 post-translational protein acetylation(GO:0034421)
5.5 16.6 GO:0036509 trimming of terminal mannose on B branch(GO:0036509)
4.1 16.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.7 16.1 GO:0034508 centromere complex assembly(GO:0034508)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 258 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 192.0 GO:0005634 nucleus(GO:0005634)
0.6 75.9 GO:0000776 kinetochore(GO:0000776)
0.5 47.6 GO:0016363 nuclear matrix(GO:0016363)
0.5 45.4 GO:0005814 centriole(GO:0005814)
2.5 33.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
8.1 32.3 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.9 32.1 GO:0090544 BAF-type complex(GO:0090544)
0.2 30.3 GO:0030027 lamellipodium(GO:0030027)
0.2 28.9 GO:0043296 apical junction complex(GO:0043296)
0.8 27.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.3 25.3 GO:0001669 acrosomal vesicle(GO:0001669)
2.6 21.1 GO:0033269 internode region of axon(GO:0033269)
1.0 20.5 GO:0016580 Sin3 complex(GO:0016580)
0.9 20.3 GO:0000242 pericentriolar material(GO:0000242)
0.1 20.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
1.6 20.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
2.9 20.1 GO:0001940 male pronucleus(GO:0001940)
2.8 19.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.8 19.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 18.6 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 374 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 52.4 GO:0003682 chromatin binding(GO:0003682)
2.4 35.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.0 33.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 33.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.4 33.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.6 31.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.7 31.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 30.3 GO:0042393 histone binding(GO:0042393)
1.8 29.5 GO:0030957 Tat protein binding(GO:0030957)
0.5 24.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 24.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 22.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 21.5 GO:0002039 p53 binding(GO:0002039)
0.6 21.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 20.7 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.3 19.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.8 19.3 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.6 18.9 GO:0017147 Wnt-protein binding(GO:0017147)
1.8 18.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.6 17.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 81.0 PID_AURORA_B_PATHWAY Aurora B signaling
1.1 49.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.6 35.7 PID_PLK1_PATHWAY PLK1 signaling events
0.5 30.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 22.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.3 20.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 20.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.8 18.6 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.7 18.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.5 18.2 PID_IFNG_PATHWAY IFN-gamma pathway
0.6 17.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
1.1 17.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
1.2 16.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 15.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.3 13.4 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
1.1 12.5 PID_ALK2_PATHWAY ALK2 signaling events
0.8 11.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.3 10.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 10.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 10.0 PID_TGFBR_PATHWAY TGF-beta receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 114.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 50.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.3 40.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.9 39.9 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.4 30.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
1.4 30.2 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.8 29.5 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.8 26.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 25.7 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
1.6 25.6 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.5 24.9 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 20.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.7 17.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.7 17.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
1.3 16.0 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.9 16.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.5 16.0 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
1.4 13.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 13.6 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.4 13.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants