Motif ID: Obox6_Obox5
Z-value: 0.693
Transcription factors associated with Obox6_Obox5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Obox5 | ENSMUSG00000074366.3 | Obox5 |
| Obox6 | ENSMUSG00000041583.7 | Obox6 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.2 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.6 | 1.7 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 0.6 | 2.8 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065) |
| 0.5 | 1.4 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.4 | 3.7 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.4 | 1.1 | GO:0042560 | 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
| 0.3 | 1.7 | GO:2000298 | regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.3 | 5.8 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.3 | 1.0 | GO:0010752 | signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752) |
| 0.3 | 0.9 | GO:0015747 | urate transport(GO:0015747) |
| 0.3 | 1.8 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.3 | 2.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.3 | 1.6 | GO:0048254 | snoRNA localization(GO:0048254) |
| 0.3 | 11.2 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.3 | 1.3 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.3 | 1.0 | GO:0040010 | positive regulation of growth rate(GO:0040010) |
| 0.2 | 0.7 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.2 | 0.7 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
| 0.2 | 0.7 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.2 | 1.6 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.2 | 0.9 | GO:0001692 | histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805) |
| 0.2 | 1.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 1.1 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) |
| 0.2 | 1.8 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
| 0.2 | 1.6 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.2 | 1.0 | GO:0090273 | regulation of somatostatin secretion(GO:0090273) |
| 0.2 | 1.5 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.2 | 0.9 | GO:0002339 | B cell selection(GO:0002339) |
| 0.2 | 2.4 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.2 | 0.9 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.2 | 1.0 | GO:0045919 | complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919) |
| 0.2 | 1.2 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.2 | 0.8 | GO:0046654 | tetrahydrofolate biosynthetic process(GO:0046654) |
| 0.1 | 1.3 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
| 0.1 | 3.5 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.1 | 17.7 | GO:0006413 | translational initiation(GO:0006413) |
| 0.1 | 0.4 | GO:1900365 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.1 | 0.1 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.1 | 0.3 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.1 | 0.8 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.1 | 0.6 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.1 | 1.7 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.1 | 0.2 | GO:0006475 | internal protein amino acid acetylation(GO:0006475) |
| 0.1 | 0.4 | GO:0097360 | chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382) |
| 0.1 | 1.0 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.1 | 0.7 | GO:0072656 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) maintenance of protein location in mitochondrion(GO:0072656) |
| 0.1 | 0.4 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.1 | 0.6 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.1 | 0.6 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.1 | 1.4 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.1 | 0.3 | GO:1903048 | regulation of acetylcholine-gated cation channel activity(GO:1903048) |
| 0.1 | 1.0 | GO:0050746 | regulation of lipoprotein metabolic process(GO:0050746) |
| 0.1 | 0.3 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.1 | 0.7 | GO:0016114 | terpenoid biosynthetic process(GO:0016114) |
| 0.1 | 0.3 | GO:2001160 | regulation of histone H3-K79 methylation(GO:2001160) |
| 0.1 | 0.3 | GO:0039017 | pronephric field specification(GO:0039003) pattern specification involved in pronephros development(GO:0039017) kidney rudiment formation(GO:0072003) kidney field specification(GO:0072004) positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0072108) regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072304) negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072305) mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) apoptotic process involved in metanephric collecting duct development(GO:1900204) apoptotic process involved in metanephric nephron tubule development(GO:1900205) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212) regulation of apoptotic process involved in metanephric collecting duct development(GO:1900214) negative regulation of apoptotic process involved in metanephric collecting duct development(GO:1900215) regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900217) negative regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900218) mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:1901147) regulation of metanephric DCT cell differentiation(GO:2000592) positive regulation of metanephric DCT cell differentiation(GO:2000594) |
| 0.1 | 0.2 | GO:0061642 | chemoattraction of axon(GO:0061642) |
| 0.1 | 0.6 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.1 | 1.0 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 1.5 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 0.2 | GO:0071873 | response to norepinephrine(GO:0071873) |
| 0.1 | 0.5 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.1 | 0.7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.1 | 0.1 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.1 | 0.2 | GO:1903225 | regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.4 | GO:1990564 | protein ufmylation(GO:0071569) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.1 | 0.3 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.1 | 0.3 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.1 | 0.2 | GO:1904049 | negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
| 0.1 | 0.1 | GO:0021539 | subthalamus development(GO:0021539) |
| 0.1 | 0.4 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.1 | 0.4 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 0.1 | 0.6 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.1 | 0.2 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.1 | 0.3 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
| 0.1 | 0.1 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.1 | 0.2 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
| 0.0 | 0.5 | GO:1903894 | regulation of IRE1-mediated unfolded protein response(GO:1903894) |
| 0.0 | 0.2 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.0 | 0.3 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.0 | 0.8 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.0 | 0.3 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.0 | 0.2 | GO:0035814 | negative regulation of renal sodium excretion(GO:0035814) |
| 0.0 | 0.3 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.0 | 0.3 | GO:0046689 | response to mercury ion(GO:0046689) |
| 0.0 | 0.5 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.3 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.0 | 0.8 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.4 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.0 | 0.2 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.0 | 0.1 | GO:2000569 | T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570) |
| 0.0 | 0.4 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.0 | 0.1 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.0 | 0.5 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 0.4 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.0 | 0.1 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.0 | 0.4 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 1.3 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.0 | 1.5 | GO:0001825 | blastocyst formation(GO:0001825) |
| 0.0 | 0.1 | GO:0060032 | notochord regression(GO:0060032) |
| 0.0 | 6.3 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 0.7 | GO:0099612 | protein localization to axon(GO:0099612) |
| 0.0 | 0.3 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.0 | 0.7 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.5 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.0 | 0.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.2 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
| 0.0 | 2.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.2 | GO:1990009 | retinal cell apoptotic process(GO:1990009) |
| 0.0 | 0.1 | GO:0006983 | ER overload response(GO:0006983) |
| 0.0 | 0.3 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.0 | 0.1 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.0 | 0.9 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 0.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.0 | 0.1 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.0 | 0.7 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.0 | 0.3 | GO:0036315 | cellular response to sterol(GO:0036315) |
| 0.0 | 1.0 | GO:0018209 | peptidyl-serine modification(GO:0018209) |
| 0.0 | 1.6 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.1 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.0 | 0.9 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.2 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.0 | 0.1 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.0 | 0.8 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 0.3 | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway(GO:0033146) |
| 0.0 | 0.3 | GO:1901898 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 0.1 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.0 | 0.4 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.2 | GO:1901020 | negative regulation of calcium ion transmembrane transporter activity(GO:1901020) |
| 0.0 | 1.1 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.0 | 0.0 | GO:0006532 | aspartate biosynthetic process(GO:0006532) |
| 0.0 | 1.9 | GO:0009566 | fertilization(GO:0009566) |
| 0.0 | 0.4 | GO:0033260 | nuclear DNA replication(GO:0033260) |
| 0.0 | 0.4 | GO:0061053 | somite development(GO:0061053) |
| 0.0 | 0.4 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.2 | GO:0006353 | DNA-templated transcription, termination(GO:0006353) |
| 0.0 | 0.3 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 0.3 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.0 | 0.1 | GO:0018002 | N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920) |
| 0.0 | 0.8 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 0.0 | 0.5 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.0 | 0.2 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.0 | 0.3 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.0 | 1.2 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.1 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.0 | 0.7 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.2 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 0.2 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 0.5 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.0 | 0.0 | GO:0045002 | double-strand break repair via single-strand annealing(GO:0045002) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.4 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.4 | 1.7 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.3 | 1.3 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.3 | 2.9 | GO:0002177 | manchette(GO:0002177) |
| 0.2 | 0.9 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.2 | 1.3 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.2 | 1.7 | GO:0060091 | kinocilium(GO:0060091) |
| 0.2 | 1.0 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.2 | 0.7 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.2 | 2.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 1.6 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 0.1 | 0.6 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.1 | 0.6 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.1 | 12.6 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 0.6 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 4.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1.0 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 1.0 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.1 | 1.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 0.8 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 0.3 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.1 | 0.5 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 0.7 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 1.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 0.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 0.8 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 0.3 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.1 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.2 | GO:1990745 | EARP complex(GO:1990745) |
| 0.0 | 0.2 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.0 | 0.3 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 0.2 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.0 | 0.7 | GO:0071004 | U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004) |
| 0.0 | 2.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.2 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 0.9 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.2 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.3 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.3 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.1 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 0.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 1.7 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 0.5 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.1 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.0 | 0.2 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
| 0.0 | 0.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 1.8 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 2.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.2 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.3 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.0 | 0.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.3 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.1 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 1.6 | GO:0044306 | neuron projection terminus(GO:0044306) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.2 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.5 | 3.7 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.4 | 2.5 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.4 | 1.1 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.3 | 1.0 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.3 | 2.7 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.3 | 1.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.3 | 1.3 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.3 | 1.3 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.3 | 19.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.3 | 1.7 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.3 | 1.3 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.3 | 1.0 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 0.2 | 0.9 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
| 0.2 | 5.8 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 0.6 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.2 | 0.8 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.2 | 0.7 | GO:0019808 | polyamine binding(GO:0019808) |
| 0.2 | 0.5 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.2 | 1.3 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 0.7 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.2 | 3.1 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.2 | 3.5 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.2 | 0.8 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 0.1 | 0.7 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.1 | 1.6 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 1.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 0.4 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.1 | 2.4 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.1 | 1.7 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 1.0 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 0.6 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.1 | 2.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 0.7 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.1 | 0.6 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.1 | 2.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 10.9 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 0.8 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 0.2 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.1 | 1.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 1.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 5.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.3 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.1 | 0.3 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.1 | 1.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.6 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.1 | 0.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 1.1 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 0.5 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.1 | 0.2 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.1 | 0.3 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.2 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.0 | 0.4 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.2 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 0.0 | 0.4 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 2.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.6 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.2 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.2 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) |
| 0.0 | 0.1 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.0 | 0.1 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.0 | 0.1 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.0 | 0.1 | GO:0015226 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
| 0.0 | 0.1 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 2.0 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.2 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 0.1 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
| 0.0 | 0.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.3 | GO:0042166 | acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166) |
| 0.0 | 0.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.5 | GO:0070402 | NADPH binding(GO:0070402) |
| 0.0 | 0.1 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.0 | 0.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 1.1 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.3 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.2 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 0.1 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.0 | 0.1 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.0 | 0.4 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.9 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 1.0 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.2 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.0 | 0.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 0.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.6 | GO:0008235 | metalloexopeptidase activity(GO:0008235) |
| 0.0 | 0.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.0 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.0 | 1.1 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.1 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 0.0 | 0.1 | GO:1990190 | peptide-glutamate-N-acetyltransferase activity(GO:1990190) |
| 0.0 | 0.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.0 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) dipeptide transporter activity(GO:0042936) |
| 0.0 | 1.0 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.9 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.0 | 0.7 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 0.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.7 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 3.6 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 1.3 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 4.2 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 1.3 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 1.0 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 2.8 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 1.6 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 1.3 | ST_ADRENERGIC | Adrenergic Pathway |
| 0.0 | 0.7 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.6 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 6.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.7 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.5 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.8 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.1 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.2 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 1.0 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.5 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.3 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.3 | PID_RHOA_PATHWAY | RhoA signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.8 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 1.0 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 3.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 2.5 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 0.9 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 5.0 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.1 | 5.1 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.7 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 2.2 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 0.2 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.1 | 1.3 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.1 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 1.0 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 1.0 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 3.8 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 0.5 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.3 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.5 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.4 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.1 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.9 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.7 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.2 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.2 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.8 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 1.0 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.3 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.8 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.0 | 0.8 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.1 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 0.2 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.6 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.1 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.1 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.3 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.4 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.2 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.3 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.2 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
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