Motif ID: Obox6_Obox5

Z-value: 0.693

Transcription factors associated with Obox6_Obox5:

Gene SymbolEntrez IDGene Name
Obox5 ENSMUSG00000074366.3 Obox5
Obox6 ENSMUSG00000041583.7 Obox6



Activity profile for motif Obox6_Obox5.

activity profile for motif Obox6_Obox5


Sorted Z-values histogram for motif Obox6_Obox5

Sorted Z-values for motif Obox6_Obox5



Network of associatons between targets according to the STRING database.



First level regulatory network of Obox6_Obox5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_1010543 15.742 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr10_+_123264076 6.457 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr3_+_95526777 5.827 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr4_+_74013442 5.484 ENSMUST00000098006.2
ENSMUST00000084474.5
 Frmd3

FERM domain containing 3

chr9_-_77347816 5.031 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr4_+_141368116 4.046 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr9_-_77347787 3.963 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr10_-_33624587 3.875 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr11_+_104231390 3.657 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr12_-_27160311 3.308 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr14_-_87141206 3.177 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr11_-_29247208 3.143 ENSMUST00000020754.3
 Ccdc104
coiled-coil domain containing 104
chr9_-_77347889 2.995 ENSMUST00000185039.1
 Mlip
muscular LMNA-interacting protein
chr7_-_112159034 2.773 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chrX_-_51681703 2.629 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681856 2.559 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr7_+_57590503 2.516 ENSMUST00000085240.4
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr13_+_110395041 2.424 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr16_+_17208135 2.373 ENSMUST00000169803.1
 Rimbp3
RIMS binding protein 3
chr14_-_87141114 2.358 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.7 GO:0006413 translational initiation(GO:0006413)
0.3 11.2 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 6.3 GO:0031032 actomyosin structure organization(GO:0031032)
0.3 5.8 GO:0030574 collagen catabolic process(GO:0030574)
0.9 5.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.4 3.7 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 3.5 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.6 2.8 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.3 2.5 GO:0071420 cellular response to histamine(GO:0071420)
0.2 2.4 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 2.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.9 GO:0009566 fertilization(GO:0009566)
0.3 1.8 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 1.8 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.6 1.7 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.3 1.7 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 1.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.3 1.6 GO:0048254 snoRNA localization(GO:0048254)
0.2 1.6 GO:0019532 oxalate transport(GO:0019532)
0.2 1.6 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.6 GO:0016605 PML body(GO:0016605)
0.5 5.4 GO:0097418 neurofibrillary tangle(GO:0097418)
0.1 4.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 2.9 GO:0002177 manchette(GO:0002177)
0.2 2.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.0 GO:0001650 fibrillar center(GO:0001650)
0.0 1.8 GO:0043204 perikaryon(GO:0043204)
0.4 1.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 1.7 GO:0060091 kinocilium(GO:0060091)
0.0 1.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 1.6 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 1.6 GO:0044306 neuron projection terminus(GO:0044306)
0.3 1.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 1.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 1.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.2 1.0 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 10.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.2 5.8 GO:0001968 fibronectin binding(GO:0001968)
0.1 5.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.3 5.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.5 3.7 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 3.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 3.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 2.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 2.7 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.4 2.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 2.4 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 2.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 2.0 GO:0019894 kinesin binding(GO:0019894)
0.3 1.7 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 1.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 1.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.4 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 3.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.2 3.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 1.3 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.1 1.3 ST_ADRENERGIC Adrenergic Pathway
0.0 1.2 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.0 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.0 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 5.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 5.0 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 3.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 3.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 2.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 1.0 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.0 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 1.0 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 0.9 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.9 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.8 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling