Motif ID: Olig2_Olig3

Z-value: 0.542

Transcription factors associated with Olig2_Olig3:

Gene SymbolEntrez IDGene Name
Olig2 ENSMUSG00000039830.8 Olig2
Olig3 ENSMUSG00000045591.5 Olig3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Olig3mm10_v2_chr10_+_19356558_193565650.403.1e-04Click!
Olig2mm10_v2_chr16_+_91225550_91225579-0.216.9e-02Click!


Activity profile for motif Olig2_Olig3.

activity profile for motif Olig2_Olig3


Sorted Z-values histogram for motif Olig2_Olig3

Sorted Z-values for motif Olig2_Olig3



Network of associatons between targets according to the STRING database.



First level regulatory network of Olig2_Olig3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92164666 7.108 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr1_-_186117251 6.175 ENSMUST00000045388.7
 Lyplal1
lysophospholipase-like 1
chr19_+_20601958 5.113 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr17_-_62606679 4.195 ENSMUST00000163332.1
 Efna5
ephrin A5
chr3_+_125404072 4.153 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_125404292 3.843 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr8_+_31089471 3.556 ENSMUST00000036631.7
ENSMUST00000170204.1
 Dusp26

dual specificity phosphatase 26 (putative)

chr1_+_110099295 3.544 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr16_-_44558864 3.369 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr9_+_76014855 3.350 ENSMUST00000008052.6
ENSMUST00000183425.1
ENSMUST00000183979.1
ENSMUST00000117981.2
 Hmgcll1



3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1



chr4_-_141598206 3.280 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr16_-_44558879 3.199 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr5_+_92925400 3.171 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr15_-_76126538 3.140 ENSMUST00000054022.5
ENSMUST00000089654.3
 BC024139

cDNA sequence BC024139

chr11_+_32276400 2.733 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr14_+_65806066 2.705 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr15_-_91191733 2.608 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr11_-_75796048 2.477 ENSMUST00000021209.7
 Doc2b
double C2, beta
chrX_-_145505136 2.465 ENSMUST00000112835.1
 Amot
angiomotin
chrX_-_145505175 2.450 ENSMUST00000143610.1
 Amot
angiomotin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.2 GO:0098734 protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) macromolecule depalmitoylation(GO:0098734)
0.2 5.9 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 5.4 GO:0030048 actin filament-based movement(GO:0030048)
1.3 5.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.2 4.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.3 4.2 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
1.2 3.6 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 3.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.7 3.3 GO:0046950 cellular ketone body metabolic process(GO:0046950)
0.2 3.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 2.8 GO:0016042 lipid catabolic process(GO:0016042)
0.5 2.7 GO:0015671 oxygen transport(GO:0015671)
0.0 2.7 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.3 2.6 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.2 2.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 2.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 2.5 GO:0008360 regulation of cell shape(GO:0008360)
0.1 2.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.7 2.2 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.0 2.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 GO:0044295 axonal growth cone(GO:0044295)
0.1 5.3 GO:0008180 COP9 signalosome(GO:0008180)
0.4 4.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 4.0 GO:0043296 apical junction complex(GO:0043296)
0.0 3.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 2.7 GO:0005833 hemoglobin complex(GO:0005833)
0.0 2.5 GO:0031201 SNARE complex(GO:0031201)
0.7 2.0 GO:0044299 C-fiber(GO:0044299)
0.2 1.9 GO:0005775 vacuolar lumen(GO:0005775)
0.2 1.9 GO:0032426 stereocilium tip(GO:0032426)
0.0 1.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.7 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.7 GO:0005874 microtubule(GO:0005874)
0.3 1.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.5 GO:0001772 immunological synapse(GO:0001772)
0.0 1.4 GO:0043198 dendritic shaft(GO:0043198)
0.2 1.3 GO:0033010 paranodal junction(GO:0033010)
0.1 1.3 GO:0031616 spindle pole centrosome(GO:0031616)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 8.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.6 6.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 6.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
1.0 5.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
1.0 4.9 GO:0043532 angiostatin binding(GO:0043532)
1.2 3.6 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.5 3.5 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 3.5 GO:0005167 neurotrophin TRK receptor binding(GO:0005167)
0.8 3.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 3.3 GO:0031005 filamin binding(GO:0031005)
0.0 2.8 GO:0051015 actin filament binding(GO:0051015)
0.5 2.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 2.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.3 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405)
0.7 2.2 GO:0071633 dihydroceramidase activity(GO:0071633)
0.1 2.2 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 2.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 1.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.9 GO:0005537 mannose binding(GO:0005537)
0.1 1.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.6 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.7 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.1 1.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.1 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.2 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 6.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 5.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
1.3 5.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 3.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.5 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.1 1.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 0.8 REACTOME_POL_SWITCHING Genes involved in Polymerase switching