Motif ID: Onecut1_Cux2
Z-value: 1.146
Transcription factors associated with Onecut1_Cux2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cux2 | ENSMUSG00000042589.12 | Cux2 |
| Cux2 | ENSMUSG00000072641.1 | Cux2 |
| Onecut1 | ENSMUSG00000043013.9 | Onecut1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cux2 | mm10_v2_chr5_-_122049822_122049882 | -0.74 | 2.2e-14 | Click! |
| Onecut1 | mm10_v2_chr9_+_74861888_74861921 | 0.46 | 2.0e-05 | Click! |
Top targets:
Showing 1 to 20 of 98 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 49 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 45.2 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 2.7 | 40.4 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 6.9 | 20.7 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 0.3 | 19.6 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.2 | 14.2 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.4 | 12.7 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.1 | 11.2 | GO:0060349 | bone morphogenesis(GO:0060349) |
| 1.6 | 9.5 | GO:0021965 | spinal cord ventral commissure morphogenesis(GO:0021965) |
| 0.2 | 7.9 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.5 | 7.1 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.5 | 5.0 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.3 | 4.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.3 | 4.2 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 1.4 | 4.1 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.0 | 3.4 | GO:0050808 | synapse organization(GO:0050808) |
| 1.1 | 3.3 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.2 | 3.2 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.4 | 2.8 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
| 0.2 | 2.8 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 0.3 | 2.6 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 31 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 59.1 | GO:0005829 | cytosol(GO:0005829) |
| 0.2 | 51.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 6.9 | 20.7 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.1 | 14.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.9 | 9.5 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 4.7 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 4.2 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 4.2 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.2 | 4.1 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 3.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.3 | 3.2 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.2 | 3.2 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 2.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.6 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 2.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.6 | 2.2 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.2 | 1.9 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 1.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 1.6 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 1.6 | GO:0043296 | apical junction complex(GO:0043296) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 40.4 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.2 | 38.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 21.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.8 | 20.7 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 15.2 | GO:0003779 | actin binding(GO:0003779) |
| 1.9 | 13.0 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.2 | 12.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 10.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.6 | 9.5 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.6 | 7.1 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.3 | 4.1 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 4.0 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 3.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 3.5 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 3.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 3.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 2.8 | GO:0016746 | transferase activity, transferring acyl groups(GO:0016746) |
| 0.0 | 2.7 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.7 | 2.6 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.4 | 2.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
Gene overrepresentation in C2:CP category:
Showing 1 to 12 of 12 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.6 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 9.5 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 4.2 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 4.1 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.1 | 3.2 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 1.9 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.9 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 1.4 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.5 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.4 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 0.3 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 20 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 23.7 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.8 | 20.7 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.3 | 13.0 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.7 | 10.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 5.3 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 3.2 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 2.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 2.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.3 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 1.9 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 1.5 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.4 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 1.0 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.9 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.8 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.0 | 0.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.4 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.3 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.3 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.2 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
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