Motif ID: Osr2_Osr1

Z-value: 1.062

Transcription factors associated with Osr2_Osr1:

Gene SymbolEntrez IDGene Name
Osr1 ENSMUSG00000048387.7 Osr1
Osr2 ENSMUSG00000022330.4 Osr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Osr1mm10_v2_chr12_+_9574437_95744480.191.1e-01Click!


Activity profile for motif Osr2_Osr1.

activity profile for motif Osr2_Osr1


Sorted Z-values histogram for motif Osr2_Osr1

Sorted Z-values for motif Osr2_Osr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Osr2_Osr1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 168 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_80128834 12.278 ENSMUST00000102654.4
ENSMUST00000102655.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr1_+_90203980 11.456 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr4_+_13743424 10.853 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_144209448 7.093 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr6_-_144209471 7.039 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 6.192 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr4_+_102087543 6.117 ENSMUST00000106911.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_-_134254076 5.971 ENSMUST00000060050.5
 Grrp1
glycine/arginine rich protein 1
chr7_-_57509995 5.247 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr6_-_59024470 4.967 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr2_+_136892168 4.846 ENSMUST00000099311.2
 Slx4ip
SLX4 interacting protein
chr19_-_41206774 4.664 ENSMUST00000025986.7
ENSMUST00000169941.1
 Tll2

tolloid-like 2

chr9_-_16378231 4.554 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr10_-_63927434 4.473 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr3_-_89322883 4.466 ENSMUST00000029673.5
 Efna3
ephrin A3
chr6_-_59024340 4.368 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr19_-_14598031 4.152 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14597983 3.996 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_+_27217011 3.956 ENSMUST00000164746.1
ENSMUST00000172302.1
 Vldlr

very low density lipoprotein receptor

chr7_-_123500449 3.906 ENSMUST00000042470.7
ENSMUST00000128217.1
 Zkscan2

zinc finger with KRAB and SCAN domains 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 20.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.7 12.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 11.5 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.1 7.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.8 7.3 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
1.8 7.2 GO:0061623 glycolytic process from galactose(GO:0061623)
0.7 6.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.5 6.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 5.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 4.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.9 4.7 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.1 4.6 GO:0010842 retina layer formation(GO:0010842)
0.9 4.5 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 4.3 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.2 3.7 GO:0006884 cell volume homeostasis(GO:0006884)
1.1 3.2 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.5 3.2 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.5 2.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.5 2.2 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.4 2.2 GO:0048254 snoRNA localization(GO:0048254)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 15.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 15.3 GO:0043025 neuronal cell body(GO:0043025)
0.1 10.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 7.9 GO:0097458 neuron part(GO:0097458)
0.2 6.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 5.6 GO:0031430 M band(GO:0031430)
0.3 5.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 5.1 GO:0030425 dendrite(GO:0030425)
0.0 4.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.3 4.0 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
1.2 3.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.8 3.4 GO:1990032 parallel fiber(GO:1990032)
0.0 3.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.5 2.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.3 2.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 2.2 GO:0070761 pre-snoRNP complex(GO:0070761)
0.1 2.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 2.1 GO:0060170 ciliary membrane(GO:0060170)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 17.3 GO:0046982 protein heterodimerization activity(GO:0046982)
1.8 12.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
3.8 11.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.4 7.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 6.5 GO:0030507 spectrin binding(GO:0030507)
0.2 6.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 5.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 4.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 4.2 GO:0070064 proline-rich region binding(GO:0070064)
1.3 4.0 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.1 3.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 3.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 3.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 3.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 2.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.8 GO:0005496 steroid binding(GO:0005496)
0.1 2.5 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 5.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 4.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 4.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 3.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 12.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 7.0 REACTOME_METABOLISM_OF_CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 6.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 5.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 4.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.1 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 2.0 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.0 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 1.8 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.8 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.7 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.7 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.4 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events