Motif ID: Otx1

Z-value: 0.340


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_22001631-0.454.1e-05Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_123264076 5.497 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr11_+_94936224 2.968 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr13_-_60897439 2.211 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr12_+_103434211 2.134 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr2_-_60963192 1.644 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr1_-_165708088 1.536 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr14_-_87141206 1.489 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr13_-_92030897 1.432 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr8_-_54718664 1.117 ENSMUST00000144711.2
ENSMUST00000093510.2
 Wdr17

WD repeat domain 17

chr3_+_18054258 1.057 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr2_-_153225396 1.037 ENSMUST00000099194.2
 Tspyl3
TSPY-like 3
chr15_-_74734313 1.010 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr7_-_83550258 0.990 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chr15_-_79285502 0.986 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr14_-_87141114 0.985 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr5_-_104456467 0.946 ENSMUST00000069263.4
 Gm10047
predicted gene 10047
chr6_-_29507946 0.927 ENSMUST00000101614.3
ENSMUST00000078112.6
 Kcp

kielin/chordin-like protein

chr7_-_79848191 0.921 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr13_+_104178797 0.869 ENSMUST00000022225.5
ENSMUST00000069187.5
 Trim23

tripartite motif-containing 23

chrX_-_167209149 0.782 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr10_+_127642975 0.677 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr8_-_46151705 0.623 ENSMUST00000041582.8
 Snx25
sorting nexin 25
chr1_+_131910458 0.601 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr5_+_109923400 0.580 ENSMUST00000112544.1
 Gm15446
predicted gene 15446
chr12_-_27160311 0.550 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr11_-_116694802 0.550 ENSMUST00000079545.5
 St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr7_-_118129567 0.473 ENSMUST00000032888.7
 Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr3_+_66985947 0.372 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr2_+_154656959 0.370 ENSMUST00000044277.9
 Chmp4b
charged multivesicular body protein 4B
chrX_-_95956890 0.355 ENSMUST00000079987.6
ENSMUST00000113864.2
 Las1l

LAS1-like (S. cerevisiae)

chr19_+_5024006 0.353 ENSMUST00000025826.5
 Slc29a2
solute carrier family 29 (nucleoside transporters), member 2
chr16_+_23107754 0.347 ENSMUST00000077605.5
ENSMUST00000115341.3
 Eif4a2

eukaryotic translation initiation factor 4A2

chr6_+_145953429 0.347 ENSMUST00000111701.1
 Sspn
sarcospan
chr10_+_29313164 0.338 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr19_+_4097392 0.323 ENSMUST00000174514.1
ENSMUST00000174149.1
 Cdk2ap2

CDK2-associated protein 2

chr17_+_8165501 0.322 ENSMUST00000097419.3
ENSMUST00000024636.8
 Fgfr1op

Fgfr1 oncogene partner

chr10_+_3973086 0.308 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr3_+_66985647 0.282 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr8_-_47675556 0.278 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr14_-_74947865 0.265 ENSMUST00000088970.5
 Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr17_-_50094277 0.258 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr2_-_156180135 0.255 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr10_-_7473361 0.244 ENSMUST00000169796.2
ENSMUST00000177585.1
 Ulbp1

UL16 binding protein 1

chr1_+_118321834 0.220 ENSMUST00000027626.6
ENSMUST00000112688.3
 Mki67ip

Mki67 (FHA domain) interacting nucleolar phosphoprotein

chr1_-_118311132 0.210 ENSMUST00000027623.7
 Tsn
translin
chr9_+_68653761 0.209 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr11_+_103116228 0.200 ENSMUST00000053063.5
 Hexim1
hexamethylene bis-acetamide inducible 1
chr13_-_55321928 0.195 ENSMUST00000035242.7
 Rab24
RAB24, member RAS oncogene family
chr2_+_177897096 0.191 ENSMUST00000108935.1
 Gm14327
predicted gene 14327
chr13_+_21495218 0.188 ENSMUST00000104942.1
 AK157302
cDNA sequence AK157302
chrX_+_37126777 0.184 ENSMUST00000016553.4
 Nkap
NFKB activating protein
chr11_+_3963970 0.182 ENSMUST00000020705.4
ENSMUST00000109985.1
 Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr4_-_41517326 0.176 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr4_+_58943575 0.170 ENSMUST00000107554.1
 Zkscan16
zinc finger with KRAB and SCAN domains 16
chr13_+_18717289 0.152 ENSMUST00000072961.4
 Vps41
vacuolar protein sorting 41 (yeast)
chr2_-_144011202 0.150 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr10_-_93889758 0.147 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
 Metap2



methionine aminopeptidase 2



chr9_-_20521375 0.139 ENSMUST00000068296.7
ENSMUST00000174462.1
 Zfp266

zinc finger protein 266

chr14_+_105258673 0.132 ENSMUST00000136040.2
 Ndfip2
Nedd4 family interacting protein 2
chr2_+_112284561 0.132 ENSMUST00000053666.7
 Slc12a6
solute carrier family 12, member 6
chr9_-_109082372 0.131 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr14_-_122913751 0.114 ENSMUST00000160401.1
 Ggact
gamma-glutamylamine cyclotransferase
chr18_+_80206887 0.106 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chr7_-_100662315 0.099 ENSMUST00000151123.1
ENSMUST00000107047.2
 Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_-_105960099 0.097 ENSMUST00000118209.1
 Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr7_-_30072801 0.096 ENSMUST00000183115.1
ENSMUST00000182919.1
ENSMUST00000183190.1
ENSMUST00000080834.8
 Zfp82



zinc finger protein 82



chr19_+_41933464 0.095 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr18_-_46597299 0.088 ENSMUST00000036030.7
 Tmed7
transmembrane emp24 protein transport domain containing 7
chr11_+_78346666 0.086 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr2_+_129065934 0.075 ENSMUST00000035812.7
 Ttl
tubulin tyrosine ligase
chr7_-_4063195 0.072 ENSMUST00000068865.5
ENSMUST00000086400.6
 Lair1

leukocyte-associated Ig-like receptor 1

chr14_+_29968308 0.071 ENSMUST00000112268.1
 Selk
selenoprotein K
chr5_-_100373484 0.067 ENSMUST00000182433.1
 Sec31a
Sec31 homolog A (S. cerevisiae)
chr3_+_101377074 0.066 ENSMUST00000043983.5
 Igsf3
immunoglobulin superfamily, member 3
chr19_-_10869757 0.063 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr17_-_47611449 0.061 ENSMUST00000024783.8
 Bysl
bystin-like
chr7_-_100662414 0.051 ENSMUST00000079176.6
 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr17_+_47611570 0.049 ENSMUST00000024778.2
 Med20
mediator complex subunit 20
chr16_-_59632520 0.045 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chr5_-_62765618 0.045 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrM_+_10167 0.044 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr10_+_61648552 0.042 ENSMUST00000020286.6
 Ppa1
pyrophosphatase (inorganic) 1
chr17_-_45686899 0.039 ENSMUST00000156254.1
 Tmem63b
transmembrane protein 63b
chr11_+_115564434 0.037 ENSMUST00000021085.4
 Nup85
nucleoporin 85
chr18_+_86711520 0.031 ENSMUST00000122464.1
 Cbln2
cerebellin 2 precursor protein
chr16_+_91647859 0.024 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
 Son



Son DNA binding protein



chr13_+_21180179 0.014 ENSMUST00000021761.5
 Trim27
tripartite motif-containing 27
chr5_-_5749317 0.007 ENSMUST00000015796.2
 Steap1
six transmembrane epithelial antigen of the prostate 1
chr3_+_54481429 0.002 ENSMUST00000091130.3
 Gm5641
predicted gene 5641

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 0.6 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.2 1.5 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.2 1.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.2 0.7 GO:0048289 interleukin-4-mediated signaling pathway(GO:0035771) isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.1 0.6 GO:0097503 sialylation(GO:0097503)
0.1 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.5 GO:0002036 regulation of L-glutamate transport(GO:0002036) endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.4 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1 0.9 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 0.8 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.3 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 1.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 2.1 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.6 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 1.2 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.9 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.2 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.4 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.3 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.4 GO:0015858 nucleoside transport(GO:0015858)
0.0 0.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539) regulation of cholesterol homeostasis(GO:2000188)
0.0 0.7 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.3 GO:0034453 microtubule anchoring(GO:0034453)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0005584 collagen type I trimer(GO:0005584)
0.2 0.9 GO:0031983 vesicle lumen(GO:0031983)
0.1 1.1 GO:0071439 clathrin complex(GO:0071439)
0.1 0.5 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 2.1 GO:0005521 lamin binding(GO:0005521)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.3 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.6 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.6 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.0 GO:0004427 inorganic diphosphatase activity(GO:0004427)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 1.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.7 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 2.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell