Motif ID: Otx1

Z-value: 0.340


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_22001631-0.454.1e-05Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_123264076 5.497 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr11_+_94936224 2.968 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr13_-_60897439 2.211 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr12_+_103434211 2.134 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr2_-_60963192 1.644 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr1_-_165708088 1.536 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr14_-_87141206 1.489 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr13_-_92030897 1.432 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr8_-_54718664 1.117 ENSMUST00000144711.2
ENSMUST00000093510.2
 Wdr17

WD repeat domain 17

chr3_+_18054258 1.057 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr2_-_153225396 1.037 ENSMUST00000099194.2
 Tspyl3
TSPY-like 3
chr15_-_74734313 1.010 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr7_-_83550258 0.990 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chr15_-_79285502 0.986 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr14_-_87141114 0.985 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr5_-_104456467 0.946 ENSMUST00000069263.4
 Gm10047
predicted gene 10047
chr6_-_29507946 0.927 ENSMUST00000101614.3
ENSMUST00000078112.6
 Kcp

kielin/chordin-like protein

chr7_-_79848191 0.921 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr13_+_104178797 0.869 ENSMUST00000022225.5
ENSMUST00000069187.5
 Trim23

tripartite motif-containing 23

chrX_-_167209149 0.782 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 2.1 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.2 1.5 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 1.2 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.2 1.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 1.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.9 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.9 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.8 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.2 0.7 GO:0048289 interleukin-4-mediated signaling pathway(GO:0035771) isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.7 GO:0046677 response to antibiotic(GO:0046677)
0.2 0.6 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.6 GO:0097503 sialylation(GO:0097503)
0.0 0.6 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.5 GO:0002036 regulation of L-glutamate transport(GO:0002036) endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.4 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.4 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.4 GO:0015858 nucleoside transport(GO:0015858)
0.1 0.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.0 GO:0005584 collagen type I trimer(GO:0005584)
0.0 1.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.1 GO:0071439 clathrin complex(GO:0071439)
0.2 0.9 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.5 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 2.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.1 GO:0005521 lamin binding(GO:0005521)
0.0 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.6 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.3 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.0 GO:0004427 inorganic diphosphatase activity(GO:0004427)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 2.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 1.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.7 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell