Motif ID: Pax2

Z-value: 1.117


Transcription factors associated with Pax2:

Gene SymbolEntrez IDGene Name
Pax2 ENSMUSG00000004231.9 Pax2



Activity profile for motif Pax2.

activity profile for motif Pax2


Sorted Z-values histogram for motif Pax2

Sorted Z-values for motif Pax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_135212557 15.682 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr1_-_82291370 10.985 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr3_+_159495408 10.429 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr5_-_106458440 9.481 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr4_+_148039035 9.329 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039097 8.452 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr12_-_101028983 8.013 ENSMUST00000068411.3
ENSMUST00000085096.3
 Ccdc88c

coiled-coil domain containing 88C

chr6_+_113531675 7.884 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr10_+_41519493 7.418 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr7_-_37773555 7.186 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr9_-_91365778 6.846 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr12_-_102878406 6.845 ENSMUST00000045652.6
 Btbd7
BTB (POZ) domain containing 7
chr9_-_91365756 6.563 ENSMUST00000034927.6
 Zic1
zinc finger protein of the cerebellum 1
chr1_+_106171752 6.101 ENSMUST00000061047.6
 Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
chr2_+_84839395 5.723 ENSMUST00000146816.1
ENSMUST00000028469.7
 Slc43a1

solute carrier family 43, member 1

chr5_+_64803513 5.262 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr10_+_127063599 5.242 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr11_-_101171302 5.086 ENSMUST00000164474.1
ENSMUST00000043397.7
 Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr2_-_169405435 5.066 ENSMUST00000131509.1
 4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr9_-_42124276 4.865 ENSMUST00000060989.8
 Sorl1
sortilin-related receptor, LDLR class A repeats-containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 17.8 GO:0070829 heterochromatin maintenance(GO:0070829)
2.6 15.7 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
2.6 12.9 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.2 12.7 GO:0007628 adult walking behavior(GO:0007628)
0.7 11.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.3 9.8 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
2.4 9.6 GO:0010288 response to lead ion(GO:0010288)
0.2 9.5 GO:0001709 cell fate determination(GO:0001709)
0.2 8.0 GO:0031648 protein destabilization(GO:0031648)
1.1 7.9 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 7.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 7.0 GO:0007605 sensory perception of sound(GO:0007605)
1.0 6.9 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
1.3 6.7 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.4 6.3 GO:0060746 parental behavior(GO:0060746)
1.2 6.1 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) negative regulation of protein kinase C signaling(GO:0090038)
1.5 6.0 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 6.0 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.2 5.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 5.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 15.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.3 11.9 GO:0090544 BAF-type complex(GO:0090544)
3.7 11.0 GO:0005899 insulin receptor complex(GO:0005899)
0.1 10.4 GO:0017053 transcriptional repressor complex(GO:0017053)
2.4 9.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 7.4 GO:0000793 condensed chromosome(GO:0000793)
0.6 6.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.6 6.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 5.4 GO:0000502 proteasome complex(GO:0000502)
0.0 5.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.9 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 4.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.8 GO:0016235 aggresome(GO:0016235)
0.1 4.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 4.4 GO:0048786 presynaptic active zone(GO:0048786)
0.2 4.2 GO:0010369 chromocenter(GO:0010369)
1.0 4.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.4 4.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 4.0 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.0 3.9 GO:0072686 mitotic spindle(GO:0072686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 41.4 GO:0003677 DNA binding(GO:0003677)
0.1 36.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
5.9 17.8 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
3.1 15.7 GO:0043515 kinetochore binding(GO:0043515)
0.0 14.0 GO:0005096 GTPase activator activity(GO:0005096)
1.1 11.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 9.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 8.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 7.9 GO:0070182 DNA polymerase binding(GO:0070182)
0.5 7.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 7.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 6.9 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2 6.8 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 6.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.8 6.0 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 5.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 5.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.4 4.9 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 4.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
1.2 4.8 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.9 PID_PLK1_PATHWAY PLK1 signaling events
0.4 11.0 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.7 9.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 7.9 PID_BARD1_PATHWAY BARD1 signaling events
0.1 4.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 4.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 4.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 4.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 3.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 3.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 2.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.0 PID_NECTIN_PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 12.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.5 11.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 8.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 8.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 8.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 8.0 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.8 7.9 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.4 6.1 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 5.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 5.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 5.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.8 4.2 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.1 4.1 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.4 4.0 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.6 3.5 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 3.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 2.8 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 2.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 2.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription