Motif ID: Pax3

Z-value: 0.487


Transcription factors associated with Pax3:

Gene SymbolEntrez IDGene Name
Pax3 ENSMUSG00000004872.9 Pax3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax3mm10_v2_chr1_-_78197112_78197134-0.094.4e-01Click!


Activity profile for motif Pax3.

activity profile for motif Pax3


Sorted Z-values histogram for motif Pax3

Sorted Z-values for motif Pax3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_114474312 3.857 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr12_+_109747903 2.998 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr12_+_109540979 2.812 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
 Meg3


maternally expressed 3


chr14_+_51893610 2.575 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr4_+_127077374 2.039 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr18_+_35562158 1.891 ENSMUST00000166793.1
 Matr3
matrin 3
chrX_-_103623648 1.808 ENSMUST00000156211.1
 Ftx
Ftx transcript, Xist regulator (non-protein coding)
chr12_+_38780817 1.719 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr12_+_38780284 1.668 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr10_-_70592782 1.655 ENSMUST00000162251.1
 Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr12_+_38781093 1.638 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr2_-_136387929 1.473 ENSMUST00000035264.2
ENSMUST00000077200.3
 Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chr10_+_82138253 1.403 ENSMUST00000105314.2
 AU041133
expressed sequence AU041133
chr1_+_176814660 1.323 ENSMUST00000056773.8
ENSMUST00000027785.8
 Sdccag8

serologically defined colon cancer antigen 8

chr8_-_71043040 1.278 ENSMUST00000170101.1
 Gm17576
predicted gene, 17576
chr7_+_30121915 1.257 ENSMUST00000098596.3
ENSMUST00000153792.1
 Zfp382

zinc finger protein 382

chr11_-_88851462 1.209 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr8_+_33428709 1.164 ENSMUST00000059351.7
 5930422O12Rik
RIKEN cDNA 5930422O12 gene
chr3_-_59262825 1.160 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chrX_+_159840463 1.059 ENSMUST00000112451.1
ENSMUST00000112453.2
 Sh3kbp1

SH3-domain kinase binding protein 1

chr8_+_71887264 1.033 ENSMUST00000034259.7
 Zfp709
zinc finger protein 709
chr16_+_32877775 0.988 ENSMUST00000023489.4
ENSMUST00000171325.1
 Fyttd1

forty-two-three domain containing 1

chrX_-_103623704 0.961 ENSMUST00000130063.1
ENSMUST00000125419.1
 Ftx

Ftx transcript, Xist regulator (non-protein coding)

chr3_+_36159522 0.957 ENSMUST00000165956.2
 D3Ertd254e
DNA segment, Chr 3, ERATO Doi 254, expressed
chr13_+_24327415 0.940 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr17_+_87107621 0.915 ENSMUST00000041369.6
 Socs5
suppressor of cytokine signaling 5
chr9_+_64235201 0.824 ENSMUST00000039011.3
 Uchl4
ubiquitin carboxyl-terminal esterase L4
chr4_-_25281801 0.811 ENSMUST00000102994.3
 Ufl1
UFM1 specific ligase 1
chr7_+_120843551 0.764 ENSMUST00000106489.1
ENSMUST00000143279.1
 Eef2k

eukaryotic elongation factor-2 kinase

chr17_+_21691860 0.709 ENSMUST00000072133.4
 Gm10226
predicted gene 10226
chr4_-_25281752 0.510 ENSMUST00000038705.7
 Ufl1
UFM1 specific ligase 1
chr9_-_40346290 0.468 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr1_+_87404916 0.382 ENSMUST00000173152.1
ENSMUST00000173663.1
 Gigyf2

GRB10 interacting GYF protein 2

chr2_+_168230597 0.290 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr11_+_3649494 0.271 ENSMUST00000093389.2
 Morc2a
microrchidia 2A
chr13_+_14630237 0.268 ENSMUST00000178289.1
ENSMUST00000038690.4
 AW209491

expressed sequence AW209491

chr12_+_52699297 0.242 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr16_-_88056176 0.228 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
 Grik1


glutamate receptor, ionotropic, kainate 1


chr16_-_32877723 0.165 ENSMUST00000119810.1
 1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr19_+_8757139 0.117 ENSMUST00000183939.1
 Nxf1
nuclear RNA export factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.5 5.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 1.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.3 0.9 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.2 0.9 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.2 1.3 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 1.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 2.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 2.6 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.3 GO:0018307 tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307)
0.1 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.2 GO:0032229 positive regulation of gamma-aminobutyric acid secretion(GO:0014054) negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.0 1.2 GO:0003170 heart valve development(GO:0003170)
0.0 1.0 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.1 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.4 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.8 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.5 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway(GO:2001237)
0.0 1.3 GO:0007098 centrosome cycle(GO:0007098)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0030061 mitochondrial crista(GO:0030061)
0.1 3.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0071568 UFM1 transferase activity(GO:0071568)
0.3 0.9 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.3 0.8 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.2 1.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 2.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 0.3 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 5.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.2 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.8 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors