Motif ID: Pax4

Z-value: 0.526


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_9199865 3.556 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr11_+_78499087 3.038 ENSMUST00000017488.4
 Vtn
vitronectin
chr8_-_84773381 2.946 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr4_-_88033328 2.761 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr13_-_101768154 2.500 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chrM_+_3906 2.495 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr2_-_125506385 2.293 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr10_+_119992916 2.260 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chr15_-_88978958 2.193 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr2_+_158666690 2.108 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr4_+_147132038 1.970 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chr2_+_158667119 1.951 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr13_+_109632760 1.931 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr12_+_71048338 1.915 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr9_+_32696005 1.831 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
 Ets1


E26 avian leukemia oncogene 1, 5' domain


chr10_-_62792243 1.721 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chr4_+_146610961 1.643 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chrX_+_73192222 1.620 ENSMUST00000101486.4
 Xlr3b
X-linked lymphocyte-regulated 3B
chrX_-_73097017 1.619 ENSMUST00000114524.2
ENSMUST00000074619.5
 Xlr3a

X-linked lymphocyte-regulated 3A

chr9_-_101198999 1.539 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.1 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 3.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.3 3.0 GO:0097421 liver regeneration(GO:0097421)
0.2 2.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 2.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 2.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.2 2.5 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 2.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.8 2.3 GO:1903011 negative regulation of bone development(GO:1903011)
0.2 2.2 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.1 2.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 2.2 GO:0015914 phospholipid transport(GO:0015914)
0.4 1.9 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.2 1.9 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.4 1.8 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.5 1.5 GO:0007525 somatic muscle development(GO:0007525)
0.0 1.5 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.3 1.4 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 1.2 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.1 1.2 GO:0006744 ubiquinone biosynthetic process(GO:0006744)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0055037 recycling endosome(GO:0055037)
0.0 4.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 3.2 GO:0000800 lateral element(GO:0000800)
0.6 3.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 2.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 2.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.0 GO:0070469 respiratory chain(GO:0070469)
0.0 1.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.5 GO:0032584 growth cone membrane(GO:0032584)
0.1 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 1.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.0 GO:0097433 dense body(GO:0097433)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.9 GO:0032420 stereocilium(GO:0032420)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 3.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 2.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 2.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 2.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.5 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.5 GO:0030674 protein binding, bridging(GO:0030674)
0.2 1.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 1.3 GO:0003785 actin monomer binding(GO:0003785)
0.3 1.2 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 1.0 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.8 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 0.2 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis