Motif ID: Pax5

Z-value: 1.600


Transcription factors associated with Pax5:

Gene SymbolEntrez IDGene Name
Pax5 ENSMUSG00000014030.9 Pax5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax5mm10_v2_chr4_-_44710408_447104180.281.2e-02Click!


Activity profile for motif Pax5.

activity profile for motif Pax5


Sorted Z-values histogram for motif Pax5

Sorted Z-values for motif Pax5



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78773452 21.507 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_-_77894096 14.449 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr10_+_127725392 14.398 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr2_+_91945703 13.483 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr1_-_172057573 12.604 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr9_-_82975475 12.021 ENSMUST00000034787.5
 Phip
pleckstrin homology domain interacting protein
chr1_-_190170671 11.817 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr1_-_190170178 10.702 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr2_-_34372004 10.527 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr7_-_116443439 9.529 ENSMUST00000170430.1
 Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
chr10_-_128919259 9.111 ENSMUST00000149961.1
ENSMUST00000026406.7
 Rdh5

retinol dehydrogenase 5

chr19_+_38055002 9.099 ENSMUST00000096096.4
ENSMUST00000116506.1
ENSMUST00000169673.1
 Cep55


centrosomal protein 55


chr6_+_34745952 9.009 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
 Cald1


caldesmon 1


chr7_+_51878967 8.657 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr11_+_61485431 8.479 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr6_+_34746368 8.412 ENSMUST00000142716.1
 Cald1
caldesmon 1
chr9_-_91365778 8.398 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr3_+_89520152 8.305 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr1_+_139454747 8.295 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr7_-_70366735 8.070 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 366 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 23.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
7.5 22.5 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
1.7 17.3 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
4.8 14.4 GO:0006553 lysine metabolic process(GO:0006553)
3.6 14.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.5 13.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.8 13.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 12.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 12.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
2.3 11.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.2 11.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 9.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.7 9.6 GO:0035881 amacrine cell differentiation(GO:0035881)
0.5 9.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
3.2 9.5 GO:0071579 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) regulation of zinc ion transport(GO:0071579)
0.7 9.5 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.9 9.4 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.1 9.3 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)
1.1 9.0 GO:0071802 negative regulation of podosome assembly(GO:0071802)
1.0 8.9 GO:0048251 elastic fiber assembly(GO:0048251)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 52.5 GO:0005654 nucleoplasm(GO:0005654)
0.3 19.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 17.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
1.9 17.4 GO:0030478 actin cap(GO:0030478)
0.4 12.7 GO:1990752 microtubule plus-end(GO:0035371) microtubule end(GO:1990752)
0.1 11.7 GO:0005667 transcription factor complex(GO:0005667)
3.8 11.5 GO:0036125 mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125)
0.2 10.9 GO:0005720 nuclear heterochromatin(GO:0005720)
2.2 10.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 10.4 GO:0005902 microvillus(GO:0005902)
2.6 10.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 9.9 GO:0005871 kinesin complex(GO:0005871)
0.4 9.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 9.3 GO:0005925 focal adhesion(GO:0005925)
1.7 8.3 GO:0036449 microtubule minus-end(GO:0036449)
0.8 8.1 GO:0090543 Flemming body(GO:0090543)
0.2 8.1 GO:0002102 podosome(GO:0002102)
0.2 7.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 7.7 GO:0000922 spindle pole(GO:0000922)
2.5 7.4 GO:0071953 elastic fiber(GO:0071953)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 236 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 23.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.9 22.5 GO:0050693 LBD domain binding(GO:0050693)
7.2 21.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 19.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 17.4 GO:0005178 integrin binding(GO:0005178)
1.4 16.9 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
4.1 16.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 15.6 GO:0015631 tubulin binding(GO:0015631)
0.6 15.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.4 14.0 GO:0017091 AU-rich element binding(GO:0017091)
1.1 12.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
2.9 11.5 GO:0016508 long-chain-enoyl-CoA hydratase activity(GO:0016508) long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
2.2 10.8 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 9.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 9.9 GO:0042393 histone binding(GO:0042393)
0.1 9.6 GO:0003777 microtubule motor activity(GO:0003777)
1.0 9.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.4 9.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.5 8.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 16.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 14.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 12.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 12.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 11.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 11.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 10.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.8 10.2 PID_CONE_PATHWAY Visual signal transduction: Cones
0.2 9.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 9.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 7.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.9 7.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 6.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 6.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 6.6 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 6.4 PID_PLK1_PATHWAY PLK1 signaling events
0.2 6.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.3 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.2 5.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 22.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.9 17.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 17.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 16.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.6 15.1 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.2 13.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.7 11.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.5 11.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.7 11.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.4 9.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 9.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 8.7 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 8.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 5.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 5.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.8 4.7 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2 4.6 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.2 4.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 4.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 4.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)