Motif ID: Pax6
Z-value: 0.872
Transcription factors associated with Pax6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pax6 | ENSMUSG00000027168.15 | Pax6 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pax6 | mm10_v2_chr2_+_105682463_105682547 | -0.85 | 4.5e-23 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 8.5 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 1.4 | 4.1 | GO:0010040 | response to iron(II) ion(GO:0010040) |
| 1.3 | 3.8 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 1.2 | 7.3 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 1.0 | 3.1 | GO:0097274 | urea homeostasis(GO:0097274) |
| 1.0 | 4.0 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.9 | 6.5 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.8 | 8.4 | GO:0099612 | protein localization to axon(GO:0099612) |
| 0.8 | 3.2 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
| 0.8 | 2.3 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 0.7 | 5.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.7 | 2.2 | GO:0061744 | motor behavior(GO:0061744) |
| 0.7 | 2.1 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 0.7 | 10.7 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.7 | 2.0 | GO:0002538 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) |
| 0.6 | 1.2 | GO:1990705 | cholangiocyte proliferation(GO:1990705) |
| 0.5 | 1.6 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180) |
| 0.4 | 1.7 | GO:1903542 | negative regulation of exosomal secretion(GO:1903542) |
| 0.4 | 36.1 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.4 | 4.5 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.3 | 2.3 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.3 | 2.9 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.3 | 1.5 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.3 | 5.1 | GO:0071624 | positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.3 | 1.1 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.3 | 1.3 | GO:0097527 | necroptotic signaling pathway(GO:0097527) |
| 0.2 | 0.9 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.2 | 1.4 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.2 | 0.8 | GO:2000258 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.1 | 1.1 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 0.7 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.1 | 10.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 1.9 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.1 | 0.5 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 0.1 | 0.8 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.1 | 1.0 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.1 | 0.7 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.1 | 2.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 6.3 | GO:0019882 | antigen processing and presentation(GO:0019882) |
| 0.1 | 3.5 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.1 | 6.8 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.1 | 5.4 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 1.1 | GO:0006760 | folic acid-containing compound metabolic process(GO:0006760) |
| 0.0 | 0.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.0 | 1.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 0.1 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.0 | 0.9 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.0 | 1.1 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 1.4 | GO:0007605 | sensory perception of sound(GO:0007605) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 8.4 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 1.8 | 7.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 1.0 | 5.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.0 | 4.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.8 | 2.3 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.7 | 10.7 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.3 | 37.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.3 | 3.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.3 | 8.5 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.2 | 1.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.2 | 5.4 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.2 | 1.7 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.2 | 2.9 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.2 | 2.4 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 4.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.8 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.1 | 1.1 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 1.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.7 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.2 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 0.8 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 1.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.2 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 0.9 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 1.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 3.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 7.6 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 1.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0004875 | complement receptor activity(GO:0004875) |
| 1.2 | 3.5 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 1.0 | 6.1 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.8 | 8.5 | GO:0048406 | neurotrophin TRKA receptor binding(GO:0005168) nerve growth factor binding(GO:0048406) |
| 0.7 | 2.1 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.7 | 1.3 | GO:0043120 | tumor necrosis factor binding(GO:0043120) |
| 0.7 | 10.7 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.6 | 3.2 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.6 | 7.5 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.6 | 5.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.6 | 4.0 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.6 | 7.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.5 | 5.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.4 | 1.1 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.3 | 6.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 1.8 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.2 | 6.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 1.6 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 0.9 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 0.8 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 1.1 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 36.5 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 0.5 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.0 | 1.0 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 2.3 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.0 | 1.1 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 1.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.2 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 7.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 5.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 2.3 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.0 | 0.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.9 | GO:0043022 | ribosome binding(GO:0043022) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.5 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.3 | 4.0 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 1.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 5.1 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 6.5 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.1 | 4.1 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 7.3 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.1 | 0.5 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 2.1 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 4.7 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.9 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.1 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 36.1 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.7 | 6.5 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.7 | 8.5 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.4 | 7.3 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 4.0 | REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.3 | 10.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 5.1 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 0.5 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 6.1 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 1.2 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 1.3 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.3 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 0.9 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.1 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 3.8 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.1 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 1.1 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.0 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 1.6 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.6 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.1 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.6 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
