Motif ID: Pax7

Z-value: 0.783


Transcription factors associated with Pax7:

Gene SymbolEntrez IDGene Name
Pax7 ENSMUSG00000028736.7 Pax7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax7mm10_v2_chr4_-_139833524_139833535-0.084.9e-01Click!


Activity profile for motif Pax7.

activity profile for motif Pax7


Sorted Z-values histogram for motif Pax7

Sorted Z-values for motif Pax7



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_67113909 19.707 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr4_-_14621805 17.278 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr10_+_85386813 10.654 ENSMUST00000105307.1
ENSMUST00000020231.3
 Btbd11

BTB (POZ) domain containing 11

chr4_-_14621494 9.276 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 8.962 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr15_-_37459327 7.607 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr4_+_102589687 7.287 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr3_+_55461758 6.986 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr2_+_65620829 6.838 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr10_-_62379852 6.590 ENSMUST00000143236.1
ENSMUST00000133429.1
ENSMUST00000132926.1
ENSMUST00000116238.2
 Hk1



hexokinase 1



chr15_-_64922290 5.738 ENSMUST00000023007.5
 Adcy8
adenylate cyclase 8
chr5_+_26817357 5.069 ENSMUST00000071500.6
 Dpp6
dipeptidylpeptidase 6
chr2_+_125136692 4.965 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr5_-_92348871 4.282 ENSMUST00000038816.6
ENSMUST00000118006.1
 Cxcl10

chemokine (C-X-C motif) ligand 10

chr11_-_115276973 4.229 ENSMUST00000021078.2
 Fdxr
ferredoxin reductase
chr4_+_136286061 3.751 ENSMUST00000069195.4
ENSMUST00000130658.1
 Zfp46

zinc finger protein 46

chr13_+_76579670 3.554 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr4_+_108719649 3.066 ENSMUST00000178992.1
 3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr13_-_102906046 2.890 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr19_+_8802486 2.862 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr1_+_72284367 2.736 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr6_+_145934113 2.504 ENSMUST00000032383.7
 Sspn
sarcospan
chr8_+_107031218 2.330 ENSMUST00000034388.9
 Vps4a
vacuolar protein sorting 4a (yeast)
chr2_-_33718789 2.260 ENSMUST00000130532.1
 9430024E24Rik
RIKEN cDNA 9430024E24 gene
chr19_+_41933464 2.220 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr19_-_41933276 2.214 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr8_-_34965631 2.110 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr13_-_102905740 2.048 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr18_+_38993126 1.810 ENSMUST00000097593.2
 Arhgap26
Rho GTPase activating protein 26
chr13_+_67833235 1.745 ENSMUST00000060609.7
 Gm10037
predicted gene 10037
chr7_-_137410717 1.551 ENSMUST00000120340.1
ENSMUST00000117404.1
ENSMUST00000068996.6
 9430038I01Rik


RIKEN cDNA 9430038I01 gene


chr2_+_32727682 1.401 ENSMUST00000113242.2
 Sh2d3c
SH2 domain containing 3C
chr7_-_19715395 1.398 ENSMUST00000032555.9
ENSMUST00000093552.5
 Tomm40

translocase of outer mitochondrial membrane 40 homolog (yeast)

chr14_+_76110885 1.390 ENSMUST00000022586.1
 Nufip1
nuclear fragile X mental retardation protein interacting protein 1
chr3_-_106790143 1.281 ENSMUST00000038845.8
 Cd53
CD53 antigen
chr9_-_71163224 1.248 ENSMUST00000074465.2
 Aqp9
aquaporin 9
chr14_-_76110760 1.148 ENSMUST00000022585.3
 Gpalpp1
GPALPP motifs containing 1
chr11_-_29247208 1.067 ENSMUST00000020754.3
 Ccdc104
coiled-coil domain containing 104
chr17_+_35517100 1.066 ENSMUST00000164242.2
ENSMUST00000045956.7
 Cchcr1

coiled-coil alpha-helical rod protein 1

chr13_+_75707484 1.037 ENSMUST00000001583.6
 Ell2
elongation factor RNA polymerase II 2
chr7_-_45510400 1.029 ENSMUST00000033096.7
 Nucb1
nucleobindin 1
chr11_-_87359011 0.947 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr7_+_19228334 0.934 ENSMUST00000063976.8
 Opa3
optic atrophy 3
chr5_-_138170992 0.744 ENSMUST00000139983.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr13_-_23934156 0.688 ENSMUST00000052776.2
 Hist1h2ba
histone cluster 1, H2ba
chr13_+_55445301 0.557 ENSMUST00000001115.8
ENSMUST00000099482.3
 Grk6

G protein-coupled receptor kinase 6

chr9_-_20959785 0.372 ENSMUST00000177754.1
 Dnmt1
DNA methyltransferase (cytosine-5) 1
chr7_-_98656530 0.045 ENSMUST00000038359.4
 2210018M11Rik
RIKEN cDNA 2210018M11 gene
chr19_-_15924560 0.043 ENSMUST00000162053.1
 Psat1
phosphoserine aminotransferase 1
chr2_-_150255591 0.027 ENSMUST00000063463.5
 Gm21994
predicted gene 21994

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 35.5 GO:0019532 oxalate transport(GO:0019532)
1.4 4.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.9 6.6 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.8 2.3 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.7 2.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.6 7.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 19.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.4 4.2 GO:0070995 NADPH oxidation(GO:0070995)
0.2 0.6 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.2 1.2 GO:0015791 polyol transport(GO:0015791) bile acid secretion(GO:0032782)
0.2 1.0 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.2 5.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.2 1.4 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 10.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 7.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 5.1 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.1 0.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.4 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 7.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 1.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.3 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 2.2 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.9 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.1 GO:0006611 protein export from nucleus(GO:0006611)
0.0 3.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 2.2 GO:0006364 rRNA processing(GO:0006364)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.6 GO:0097228 sperm principal piece(GO:0097228)
0.3 5.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 7.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.3 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.2 1.0 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.2 2.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 1.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 1.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 2.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 10.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 36.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 19.7 GO:0000139 Golgi membrane(GO:0000139)
0.1 5.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 1.3 GO:0001772 immunological synapse(GO:0001772)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 4.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 7.0 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 1.1 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 19.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
3.2 35.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.3 6.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.0 5.7 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.9 4.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 1.2 GO:0015254 glycerol channel activity(GO:0015254)
0.2 4.2 GO:0070402 NADPH binding(GO:0070402)
0.2 7.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 7.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 1.4 GO:0015288 porin activity(GO:0015288)
0.1 1.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.6 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 2.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 5.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 2.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.4 GO:0030515 snoRNA binding(GO:0030515)
0.0 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 10.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 4.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 5.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 6.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.1 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 2.2 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 2.9 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 1.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 19.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.5 5.7 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.4 7.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 32.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2 7.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 4.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 1.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 6.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 2.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends