Motif ID: Pax8

Z-value: 0.494


Transcription factors associated with Pax8:

Gene SymbolEntrez IDGene Name
Pax8 ENSMUSG00000026976.9 Pax8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax8mm10_v2_chr2_-_24475564_24475580-0.075.4e-01Click!


Activity profile for motif Pax8.

activity profile for motif Pax8


Sorted Z-values histogram for motif Pax8

Sorted Z-values for motif Pax8



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_6487231 4.780 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr3_+_135212557 4.767 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr7_-_42578588 4.208 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr7_+_112742025 3.811 ENSMUST00000164363.1
 Tead1
TEA domain family member 1
chr13_-_62607499 3.381 ENSMUST00000091563.4
 6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr18_-_12121460 2.536 ENSMUST00000055447.6
ENSMUST00000050228.7
ENSMUST00000092075.4
 Tmem241


transmembrane protein 241


chr18_-_66860458 2.070 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr13_-_62520451 1.979 ENSMUST00000082203.6
ENSMUST00000101547.4
 Zfp934

zinc finger protein 934

chr11_-_69801716 1.901 ENSMUST00000011285.4
ENSMUST00000102585.1
 Fgf11

fibroblast growth factor 11

chrX_-_105391726 1.697 ENSMUST00000142109.1
 5330434G04Rik
RIKEN cDNA 5330434G04 gene
chr13_-_62777089 1.577 ENSMUST00000167516.2
 Gm5141
predicted gene 5141
chr12_+_71048338 1.535 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr1_+_65186727 1.460 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing

chr2_+_177508570 1.389 ENSMUST00000108940.2
 Gm14403
predicted gene 14403
chr4_+_6191093 1.171 ENSMUST00000029907.5
 Ubxn2b
UBX domain protein 2B
chr7_+_114768736 1.033 ENSMUST00000117543.1
 Insc
inscuteable homolog (Drosophila)
chrX_-_105391770 0.960 ENSMUST00000136406.1
ENSMUST00000150604.1
 5330434G04Rik

RIKEN cDNA 5330434G04 gene

chr13_+_108214389 0.903 ENSMUST00000022207.8
 Elovl7
ELOVL family member 7, elongation of long chain fatty acids (yeast)
chr7_+_6961160 0.892 ENSMUST00000054055.6
 Usp29
ubiquitin specific peptidase 29
chr17_+_21691860 0.838 ENSMUST00000072133.4
 Gm10226
predicted gene 10226
chr12_+_84996487 0.716 ENSMUST00000101202.3
 Ylpm1
YLP motif containing 1
chr4_+_156215920 0.657 ENSMUST00000105572.1
 2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr5_+_100196611 0.645 ENSMUST00000066813.1
 Gm9932
predicted gene 9932
chr7_+_107595051 0.630 ENSMUST00000040056.7
 Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr7_-_42706369 0.608 ENSMUST00000180131.1
 Gm17067
predicted gene 17067
chr4_+_59805829 0.431 ENSMUST00000030080.6
 Snx30
sorting nexin family member 30
chr2_+_143915273 0.408 ENSMUST00000103172.3
 Dstn
destrin
chr17_+_45555693 0.394 ENSMUST00000024742.7
 Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
chr12_-_20900867 0.332 ENSMUST00000079237.5
 Zfp125
zinc finger protein 125
chrX_+_82948861 0.307 ENSMUST00000114000.1
 Dmd
dystrophin, muscular dystrophy
chr2_+_128967383 0.284 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr8_+_60655540 0.173 ENSMUST00000034066.3
 Mfap3l
microfibrillar-associated protein 3-like
chr1_+_74542881 0.133 ENSMUST00000113749.1
ENSMUST00000067916.6
ENSMUST00000113745.1
ENSMUST00000113747.1
ENSMUST00000113750.1
 Plcd4




phospholipase C, delta 4




chr16_-_17125106 0.130 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr5_-_137307633 0.104 ENSMUST00000040873.7
 Srrt
serrate RNA effector molecule homolog (Arabidopsis)
chr7_-_29906087 0.048 ENSMUST00000053521.8
 Zfp27
zinc finger protein 27

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.8 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.5 2.5 GO:0072530 purine-containing compound transmembrane transport(GO:0072530)
0.4 4.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.3 3.8 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.3 2.1 GO:2000252 negative regulation of feeding behavior(GO:2000252)
0.3 1.5 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 1.2 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 0.9 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.4 GO:0032329 serine transport(GO:0032329)
0.1 1.5 GO:0032288 myelin assembly(GO:0032288)
0.0 1.0 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.1 GO:0031053 primary miRNA processing(GO:0031053)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.8 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.4 4.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.1 1.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 4.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.5 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0043515 kinetochore binding(GO:0043515)
0.7 2.1 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.3 2.5 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.2 3.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 1.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.9 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 4.8 GO:0001047 core promoter binding(GO:0001047)
0.0 1.9 GO:0008083 growth factor activity(GO:0008083)
0.0 1.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 4.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 2.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction