Motif ID: Pbx1_Pbx3

Z-value: 1.521

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx3mm10_v2_chr2_-_34372004_343720440.748.1e-15Click!
Pbx1mm10_v2_chr1_-_168431695_168431750-0.651.6e-10Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_15463837 19.009 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr18_-_84086379 18.849 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr11_-_19018956 18.637 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chrX_+_58030622 18.025 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr11_-_84068554 16.977 ENSMUST00000164891.1
 Dusp14
dual specificity phosphatase 14
chr3_+_127633134 16.627 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr11_-_84069179 15.721 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chr11_-_84068766 15.636 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr4_-_3938354 15.530 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr11_-_19018714 14.466 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr19_+_55741810 14.430 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr3_-_8667033 13.630 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr11_-_22001605 12.181 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr4_+_59581563 11.965 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr4_+_59581645 11.605 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr19_-_9899450 11.326 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr17_-_70853482 11.188 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr4_+_144892813 10.357 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr14_-_122465677 9.716 ENSMUST00000039118.6
 Zic5
zinc finger protein of the cerebellum 5
chr2_-_116065047 8.866 ENSMUST00000028639.6
ENSMUST00000102538.4
 Meis2

Meis homeobox 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 53.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.7 37.8 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
4.3 34.3 GO:0048625 myoblast fate commitment(GO:0048625)
1.3 21.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.4 19.2 GO:0048852 diencephalon morphogenesis(GO:0048852)
6.3 19.0 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.0 18.9 GO:0055114 oxidation-reduction process(GO:0055114)
6.3 18.8 GO:0060023 soft palate development(GO:0060023)
3.0 18.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.1 15.5 GO:0060736 prostate gland growth(GO:0060736)
3.4 13.6 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
1.2 11.1 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 10.6 GO:0001843 neural tube closure(GO:0001843)
0.1 9.8 GO:0000910 cytokinesis(GO:0000910)
3.1 9.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 8.8 GO:0048469 cell maturation(GO:0048469)
0.5 8.6 GO:0007530 sex determination(GO:0007530)
0.5 8.2 GO:0006699 bile acid biosynthetic process(GO:0006699)
2.7 8.1 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
2.5 7.6 GO:0097402 neuroblast migration(GO:0097402)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 35.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
3.8 34.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.5 19.0 GO:0016592 mediator complex(GO:0016592)
1.4 17.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 17.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 12.2 GO:0016607 nuclear speck(GO:0016607)
3.8 11.3 GO:0000801 central element(GO:0000801)
0.1 8.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.8 7.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
1.2 6.9 GO:0031262 Ndc80 complex(GO:0031262)
0.2 6.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 6.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 6.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 5.9 GO:0005871 kinesin complex(GO:0005871)
0.4 5.8 GO:0008385 IkappaB kinase complex(GO:0008385)
1.4 5.7 GO:0008623 CHRAC(GO:0008623)
0.6 5.6 GO:0072687 meiotic spindle(GO:0072687)
0.4 5.1 GO:0061700 GATOR2 complex(GO:0061700)
0.1 5.0 GO:0000786 nucleosome(GO:0000786)
1.0 4.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 73.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
3.1 46.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.6 34.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 23.0 GO:0016491 oxidoreductase activity(GO:0016491)
0.5 17.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 16.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
4.5 13.6 GO:0035939 microsatellite binding(GO:0035939)
1.5 10.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 10.2 GO:0070888 E-box binding(GO:0070888)
0.3 9.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
3.1 9.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 8.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 8.1 GO:0008432 JUN kinase binding(GO:0008432)
0.2 8.1 GO:0005112 Notch binding(GO:0005112)
0.3 7.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 7.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.5 7.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
1.8 7.1 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
1.2 7.0 GO:0001069 regulatory region RNA binding(GO:0001069)
1.1 6.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 35.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 24.6 PID_PLK1_PATHWAY PLK1 signaling events
0.3 21.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 15.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 15.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 13.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 11.7 PID_ARF6_PATHWAY Arf6 signaling events
0.2 8.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 7.0 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 4.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.4 4.7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 4.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 4.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 4.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 3.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 3.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 3.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.8 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 17.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 10.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.4 8.5 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 8.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.6 8.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 6.8 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 6.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 5.9 REACTOME_KINESINS Genes involved in Kinesins
0.5 5.8 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 5.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 5.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 5.3 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.7 5.1 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.2 4.7 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 4.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 3.6 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.0 2.4 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.9 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling