Motif ID: Pbx2

Z-value: 0.750


Transcription factors associated with Pbx2:

Gene SymbolEntrez IDGene Name
Pbx2 ENSMUSG00000034673.8 Pbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx2mm10_v2_chr17_+_34592248_34592329-0.615.5e-09Click!


Activity profile for motif Pbx2.

activity profile for motif Pbx2


Sorted Z-values histogram for motif Pbx2

Sorted Z-values for motif Pbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 15.561 ENSMUST00000100572.3
 Sla
src-like adaptor
chr11_-_110095937 13.430 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr3_+_121953213 13.163 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr15_+_21111452 12.021 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr2_+_65620829 8.121 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr13_-_113663670 7.937 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr1_-_56972437 7.620 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr6_+_8259288 7.400 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr2_-_104257400 7.237 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr6_-_143947061 6.626 ENSMUST00000124233.1
 Sox5
SRY-box containing gene 5
chr15_+_92597104 5.590 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr12_+_108334341 5.355 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chrX_+_140367494 5.343 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr6_-_143947092 5.104 ENSMUST00000144289.1
ENSMUST00000111748.1
 Sox5

SRY-box containing gene 5

chr9_+_112234257 4.818 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr3_-_152982240 3.681 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_+_68572245 3.514 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr6_+_8259327 3.344 ENSMUST00000159378.1
 Gm16039
predicted gene 16039
chr8_+_93810832 3.212 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr6_+_8259379 3.125 ENSMUST00000162034.1
ENSMUST00000160705.1
ENSMUST00000159433.1
 Gm16039


predicted gene 16039



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 14.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 13.8 GO:0006869 lipid transport(GO:0006869)
1.5 11.7 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.5 7.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 5.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.6 3.9 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 3.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 3.5 GO:0001553 luteinization(GO:0001553)
0.1 3.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.4 2.5 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.4 2.5 GO:0006561 proline biosynthetic process(GO:0006561)
0.1 2.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 2.0 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.3 1.6 GO:0048254 snoRNA localization(GO:0048254)
0.2 1.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 1.6 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.4 1.5 GO:0002188 translation reinitiation(GO:0002188)
0.1 1.5 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.2 1.4 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 15.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 8.3 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 7.6 GO:0016607 nuclear speck(GO:0016607)
0.1 6.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.7 GO:0005776 autophagosome(GO:0005776)
0.4 2.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 2.5 GO:0043204 perikaryon(GO:0043204)
0.3 2.2 GO:0033269 internode region of axon(GO:0033269)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 1.8 GO:0045298 tubulin complex(GO:0045298)
0.0 1.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.6 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 1.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.1 GO:0030891 VCB complex(GO:0030891)
0.1 1.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.1 GO:0043196 varicosity(GO:0043196)
0.1 0.8 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.6 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.3 13.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 12.9 GO:0005509 calcium ion binding(GO:0005509)
0.1 9.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 7.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 5.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 4.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.3 3.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.5 3.7 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.5 3.2 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 2.8 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.6 2.5 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.4 2.5 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 2.5 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.8 GO:0044325 ion channel binding(GO:0044325)
0.0 1.8 GO:0051015 actin filament binding(GO:0051015)
0.2 1.6 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 1.6 GO:0030276 clathrin binding(GO:0030276)
0.0 1.5 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 4.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 3.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 1.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.3 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 14.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.8 5.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 3.2 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.2 2.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.5 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 2.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.1 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 0.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.4 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.1 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress