Motif ID: Pgr_Nr3c1

Z-value: 0.599

Transcription factors associated with Pgr_Nr3c1:

Gene SymbolEntrez IDGene Name
Nr3c1 ENSMUSG00000024431.8 Nr3c1
Pgr ENSMUSG00000031870.10 Pgr

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr3c1mm10_v2_chr18_-_39489880_394899150.316.1e-03Click!


Activity profile for motif Pgr_Nr3c1.

activity profile for motif Pgr_Nr3c1


Sorted Z-values histogram for motif Pgr_Nr3c1

Sorted Z-values for motif Pgr_Nr3c1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pgr_Nr3c1

PNG image of the network

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Top targets:


Showing 1 to 20 of 133 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 18.515 ENSMUST00000075312.3
 Ttr
transthyretin
chr13_-_84064772 8.989 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr14_+_99298652 4.925 ENSMUST00000005279.6
 Klf5
Kruppel-like factor 5
chr10_+_97565436 4.642 ENSMUST00000038160.4
 Lum
lumican
chr4_-_136898803 4.244 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr9_-_79718631 3.626 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr9_-_79718518 3.320 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr11_+_111066154 3.125 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr9_-_79718720 3.092 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr2_-_162661075 3.030 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr5_-_104114088 3.017 ENSMUST00000031249.3
 Sparcl1
SPARC-like 1
chr2_+_65620829 2.936 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr5_+_24364804 2.813 ENSMUST00000030834.4
ENSMUST00000115090.1
 Nos3

nitric oxide synthase 3, endothelial cell

chr6_+_17491216 2.652 ENSMUST00000080469.5
 Met
met proto-oncogene
chr3_-_152193803 2.392 ENSMUST00000050073.6
 Dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr13_+_29016267 2.325 ENSMUST00000140415.1
 A330102I10Rik
RIKEN cDNA A330102I10 gene
chr14_+_70555900 2.324 ENSMUST00000163060.1
 Hr
hairless
chr13_+_91461050 2.227 ENSMUST00000004094.8
ENSMUST00000042122.8
 Ssbp2

single-stranded DNA binding protein 2

chr16_+_43363855 2.149 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr7_-_127824469 2.147 ENSMUST00000106267.3
 Stx1b
syntaxin 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 18.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.7 4.9 GO:0032534 regulation of microvillus assembly(GO:0032534)
1.2 4.6 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 4.2 GO:0006958 complement activation, classical pathway(GO:0006958)
1.3 4.0 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 3.5 GO:0006470 protein dephosphorylation(GO:0006470)
0.4 3.1 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.9 2.8 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.4 2.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 2.7 GO:0006457 protein folding(GO:0006457)
0.3 2.5 GO:0005513 detection of calcium ion(GO:0005513)
0.1 2.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
1.1 2.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.5 2.1 GO:1904048 negative regulation of synaptic vesicle recycling(GO:1903422) regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.1 2.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 2.0 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.6 1.9 GO:0006601 creatine biosynthetic process(GO:0006601)
0.3 1.5 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.2 1.5 GO:0043615 astrocyte cell migration(GO:0043615)
0.5 1.4 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.0 GO:0005615 extracellular space(GO:0005615)
3.3 10.0 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 4.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 4.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 4.6 GO:0005581 collagen trimer(GO:0005581)
0.1 3.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 3.0 GO:0009986 cell surface(GO:0009986)
0.0 2.7 GO:0005901 caveola(GO:0005901)
0.0 2.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 2.0 GO:0030175 filopodium(GO:0030175)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.9 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.7 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 18.5 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 7.7 GO:0005518 collagen binding(GO:0005518)
0.2 4.0 GO:0030275 LRR domain binding(GO:0030275)
0.0 3.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 3.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.4 3.1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.3 3.0 GO:0070097 delta-catenin binding(GO:0070097)
0.9 2.8 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.7 2.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 2.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 2.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 2.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 2.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.9 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 1.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 1.4 GO:0005030 neurotrophin receptor activity(GO:0005030)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 18.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 12.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 3.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.4 PID_SHP2_PATHWAY SHP2 signaling
0.1 0.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.7 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.4 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.5 REACTOME_AMYLOIDS Genes involved in Amyloids
0.2 10.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.5 4.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.7 4.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 4.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 2.8 REACTOME_BOTULINUM_NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.1 2.8 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 2.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.1 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.5 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases