Motif ID: Pitx1

Z-value: 0.873


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_93913678 13.013 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr13_-_97747373 10.445 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 10.433 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_46010212 9.323 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr10_-_92165159 9.004 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr1_-_155232710 8.669 ENSMUST00000035914.3
 BC034090
cDNA sequence BC034090
chr8_+_127064022 8.385 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr8_+_127063893 7.693 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr2_+_102658640 7.614 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_-_155010984 6.885 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr14_-_54926784 6.859 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr14_-_31640878 6.663 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
 Hacl1


2-hydroxyacyl-CoA lyase 1


chr5_+_3343893 6.611 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr17_+_75005523 6.415 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr4_-_41697040 6.402 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr7_-_4752972 6.350 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr9_-_37433138 6.241 ENSMUST00000115038.1
 Robo3
roundabout homolog 3 (Drosophila)
chr6_-_124840192 6.100 ENSMUST00000024206.5
 Gnb3
guanine nucleotide binding protein (G protein), beta 3
chr2_+_119325784 6.095 ENSMUST00000102517.3
 Dll4
delta-like 4 (Drosophila)
chr5_+_3344194 5.971 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.7 GO:0016042 lipid catabolic process(GO:0016042)
2.7 16.1 GO:0003383 apical constriction(GO:0003383)
1.8 12.6 GO:0044838 cell quiescence(GO:0044838)
0.8 8.6 GO:0042572 retinol metabolic process(GO:0042572)
0.6 7.7 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
1.1 7.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.3 6.7 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.7 6.7 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
1.6 6.4 GO:0003360 brainstem development(GO:0003360)
0.3 6.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
1.2 6.2 GO:0061642 chemoattraction of axon(GO:0061642)
2.0 6.1 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
1.0 5.8 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 5.6 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
1.0 4.9 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.0 4.4 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.1 4.1 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.4 4.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 3.9 GO:0060041 retina development in camera-type eye(GO:0060041)
1.2 3.7 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 16.1 GO:0033269 internode region of axon(GO:0033269)
0.3 15.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 13.2 GO:0005923 bicellular tight junction(GO:0005923)
0.2 7.6 GO:0030673 axolemma(GO:0030673)
0.0 7.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 6.7 GO:0097470 ribbon synapse(GO:0097470)
2.1 6.4 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
2.1 6.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.3 6.4 GO:0010369 chromocenter(GO:0010369)
0.4 6.3 GO:0030061 mitochondrial crista(GO:0030061)
0.2 5.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 4.6 GO:0035253 ciliary rootlet(GO:0035253)
0.0 4.2 GO:0005802 trans-Golgi network(GO:0005802)
0.2 4.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 4.1 GO:0016363 nuclear matrix(GO:0016363)
0.1 4.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.2 3.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.3 3.5 GO:0005642 annulate lamellae(GO:0005642)
0.1 3.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 3.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.7 13.0 GO:0051393 alpha-actinin binding(GO:0051393)
4.2 12.6 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 12.2 GO:0003682 chromatin binding(GO:0003682)
0.2 8.8 GO:0005112 Notch binding(GO:0005112)
0.4 8.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 8.2 GO:0051020 GTPase binding(GO:0051020)
1.3 7.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.8 6.7 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.7 6.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.9 6.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.6 6.4 GO:0050436 microfibril binding(GO:0050436)
1.1 6.4 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 5.9 GO:0017124 SH3 domain binding(GO:0017124)
0.4 5.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
1.3 5.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 4.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 4.6 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 4.4 GO:0030332 cyclin binding(GO:0030332)
0.2 4.2 GO:0017160 Ral GTPase binding(GO:0017160)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.3 12.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 8.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.7 8.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.1 8.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 6.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 5.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 3.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 3.5 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.6 3.1 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 2.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.8 2.4 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 1.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 1.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.9 PID_FGF_PATHWAY FGF signaling pathway
0.1 0.8 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 16.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 12.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 9.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.8 8.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.4 7.1 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.2 6.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 6.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 5.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.4 4.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 3.5 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
1.0 3.1 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 3.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 3.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 2.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 2.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 2.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 2.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.5 2.4 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.2 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants