Motif ID: Pitx2_Otx2
Z-value: 1.702


Transcription factors associated with Pitx2_Otx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Otx2 | ENSMUSG00000021848.9 | Otx2 |
Pitx2 | ENSMUSG00000028023.10 | Pitx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Otx2 | mm10_v2_chr14_-_48667508_48667644 | 0.19 | 9.5e-02 | Click! |
Pitx2 | mm10_v2_chr3_+_129199878_129199913 | 0.08 | 5.1e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 411 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 39.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
2.0 | 19.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.8 | 18.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.2 | 17.2 | GO:0010921 | regulation of phosphatase activity(GO:0010921) |
2.3 | 13.9 | GO:0046502 | uroporphyrinogen III metabolic process(GO:0046502) |
2.6 | 13.2 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
2.0 | 11.9 | GO:0003383 | apical constriction(GO:0003383) |
0.2 | 11.8 | GO:0009060 | aerobic respiration(GO:0009060) |
0.1 | 11.7 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
3.5 | 10.4 | GO:0016095 | polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310) |
0.2 | 10.3 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
0.3 | 9.7 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
0.1 | 9.7 | GO:0031109 | microtubule polymerization or depolymerization(GO:0031109) |
0.3 | 9.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
3.0 | 8.9 | GO:0042732 | D-xylose metabolic process(GO:0042732) |
0.2 | 8.9 | GO:0043029 | T cell homeostasis(GO:0043029) |
2.9 | 8.8 | GO:0015938 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356) |
0.1 | 8.6 | GO:1901799 | negative regulation of proteasomal protein catabolic process(GO:1901799) |
0.7 | 8.1 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
1.1 | 7.6 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 213 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 43.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.1 | 29.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.6 | 28.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.5 | 19.8 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
2.4 | 19.4 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.1 | 19.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
0.0 | 18.6 | GO:0005739 | mitochondrion(GO:0005739) |
0.2 | 17.5 | GO:0005643 | nuclear pore(GO:0005643) |
0.8 | 15.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.3 | 12.8 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.4 | 12.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
1.5 | 11.9 | GO:0033269 | internode region of axon(GO:0033269) |
0.7 | 9.9 | GO:0005652 | nuclear lamina(GO:0005652) |
1.4 | 9.5 | GO:0001940 | male pronucleus(GO:0001940) |
1.5 | 9.1 | GO:1990393 | 3M complex(GO:1990393) |
0.7 | 8.5 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
0.6 | 8.5 | GO:0031105 | septin complex(GO:0031105) |
0.2 | 8.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.2 | 8.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
0.8 | 7.4 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 291 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 66.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
2.7 | 40.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.1 | 23.6 | GO:0045296 | cadherin binding(GO:0045296) |
1.4 | 19.7 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.5 | 14.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.1 | 13.5 | GO:0003774 | motor activity(GO:0003774) |
0.8 | 12.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
1.6 | 12.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.3 | 12.4 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.4 | 12.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
2.1 | 10.4 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.1 | 10.4 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
0.1 | 9.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.2 | 9.8 | GO:0016651 | oxidoreductase activity, acting on NAD(P)H(GO:0016651) |
0.2 | 9.5 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
1.3 | 9.1 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
0.2 | 9.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.6 | 8.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
0.4 | 8.9 | GO:0016675 | oxidoreductase activity, acting on a heme group of donors(GO:0016675) |
2.9 | 8.8 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 65 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 25.2 | PID_ATR_PATHWAY | ATR signaling pathway |
0.6 | 18.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
0.4 | 16.5 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.2 | 15.5 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
0.3 | 13.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.4 | 12.2 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.2 | 11.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.7 | 9.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.1 | 5.9 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
0.0 | 5.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.2 | 5.8 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.2 | 5.6 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.1 | 5.4 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.2 | 5.3 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
0.1 | 5.2 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.3 | 5.1 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.0 | 5.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.1 | 5.0 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
0.2 | 4.8 | PID_MYC_PATHWAY | C-MYC pathway |
0.2 | 4.5 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 102 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 70.0 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
0.5 | 27.1 | REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
1.3 | 21.2 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
1.2 | 19.8 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
0.9 | 19.7 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.3 | 18.7 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
0.2 | 17.3 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
0.3 | 16.5 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.6 | 15.7 | REACTOME_KINESINS | Genes involved in Kinesins |
0.1 | 12.4 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.5 | 11.2 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.7 | 11.1 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
0.2 | 11.0 | REACTOME_PHASE_II_CONJUGATION | Genes involved in Phase II conjugation |
0.3 | 9.6 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
0.3 | 6.9 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
0.2 | 6.5 | REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
0.2 | 6.3 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
0.1 | 5.8 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.2 | 5.7 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.2 | 5.7 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |