Motif ID: Pitx2_Otx2

Z-value: 1.702

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx2mm10_v2_chr14_-_48667508_486676440.199.5e-02Click!
Pitx2mm10_v2_chr3_+_129199878_1291999130.085.1e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_88898664 19.705 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr4_-_117182623 13.234 ENSMUST00000065896.2
Kif2c
kinesin family member 2C
chr9_-_70421533 12.957 ENSMUST00000034742.6
Ccnb2
cyclin B2
chr4_+_80910646 12.774 ENSMUST00000055922.3
Lurap1l
leucine rich adaptor protein 1-like
chr8_+_127447669 11.931 ENSMUST00000159511.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr11_-_84068766 11.566 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr6_+_56017489 11.403 ENSMUST00000052827.4
Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr11_-_84068554 11.030 ENSMUST00000164891.1
Dusp14
dual specificity phosphatase 14
chr11_-_106998483 11.005 ENSMUST00000124541.1
Kpna2
karyopherin (importin) alpha 2
chr6_+_34354119 10.444 ENSMUST00000038406.6
Akr1b8
aldo-keto reductase family 1, member B8
chr11_-_84069179 10.205 ENSMUST00000138208.1
Dusp14
dual specificity phosphatase 14
chr10_-_128180265 9.491 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr7_+_16992708 9.108 ENSMUST00000094805.4
Ccdc8
coiled-coil domain containing 8
chr11_+_97029925 8.854 ENSMUST00000021249.4
Scrn2
secernin 2
chr14_-_47411666 8.539 ENSMUST00000111778.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr18_+_34751803 8.043 ENSMUST00000181453.1
ENSMUST00000181641.1
2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr7_-_99353104 7.563 ENSMUST00000169437.1
ENSMUST00000094154.4
Serpinh1

serine (or cysteine) peptidase inhibitor, clade H, member 1

chr7_-_75782080 7.546 ENSMUST00000181224.1
AU020206
expressed sequence AU020206
chr11_+_101448403 7.483 ENSMUST00000010502.6
Ifi35
interferon-induced protein 35
chr18_-_74207771 7.391 ENSMUST00000040188.8
ENSMUST00000177604.1
Ska1

spindle and kinetochore associated complex subunit 1


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 411 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 39.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
2.0 19.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.8 18.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 17.2 GO:0010921 regulation of phosphatase activity(GO:0010921)
2.3 13.9 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
2.6 13.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
2.0 11.9 GO:0003383 apical constriction(GO:0003383)
0.2 11.8 GO:0009060 aerobic respiration(GO:0009060)
0.1 11.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
3.5 10.4 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.2 10.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.3 9.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 9.7 GO:0031109 microtubule polymerization or depolymerization(GO:0031109)
0.3 9.3 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
3.0 8.9 GO:0042732 D-xylose metabolic process(GO:0042732)
0.2 8.9 GO:0043029 T cell homeostasis(GO:0043029)
2.9 8.8 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.1 8.6 GO:1901799 negative regulation of proteasomal protein catabolic process(GO:1901799)
0.7 8.1 GO:0018065 protein-cofactor linkage(GO:0018065)
1.1 7.6 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 43.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 29.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.6 28.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 19.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
2.4 19.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 19.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 18.6 GO:0005739 mitochondrion(GO:0005739)
0.2 17.5 GO:0005643 nuclear pore(GO:0005643)
0.8 15.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 12.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 12.7 GO:0035371 microtubule plus-end(GO:0035371)
1.5 11.9 GO:0033269 internode region of axon(GO:0033269)
0.7 9.9 GO:0005652 nuclear lamina(GO:0005652)
1.4 9.5 GO:0001940 male pronucleus(GO:0001940)
1.5 9.1 GO:1990393 3M complex(GO:1990393)
0.7 8.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.6 8.5 GO:0031105 septin complex(GO:0031105)
0.2 8.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 8.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.8 7.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 291 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 66.2 GO:0003735 structural constituent of ribosome(GO:0003735)
2.7 40.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 23.6 GO:0045296 cadherin binding(GO:0045296)
1.4 19.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 14.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 13.5 GO:0003774 motor activity(GO:0003774)
0.8 12.8 GO:0051010 microtubule plus-end binding(GO:0051010)
1.6 12.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 12.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 12.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.1 10.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 10.4 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 9.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 9.8 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.2 9.5 GO:0016831 carboxy-lyase activity(GO:0016831)
1.3 9.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.2 9.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.6 8.9 GO:0016805 dipeptidase activity(GO:0016805)
0.4 8.9 GO:0016675 oxidoreductase activity, acting on a heme group of donors(GO:0016675)
2.9 8.8 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 25.2 PID_ATR_PATHWAY ATR signaling pathway
0.6 18.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 16.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 15.5 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.3 13.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 12.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 11.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.7 9.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.9 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 5.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 5.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 5.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 5.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 5.3 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 5.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.3 5.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 5.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 4.8 PID_MYC_PATHWAY C-MYC pathway
0.2 4.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 70.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.5 27.1 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
1.3 21.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.2 19.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.9 19.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 18.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 17.3 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3 16.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.6 15.7 REACTOME_KINESINS Genes involved in Kinesins
0.1 12.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 11.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.7 11.1 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 11.0 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation
0.3 9.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 6.9 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.2 6.5 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.2 6.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 5.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 5.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 5.7 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport