Motif ID: Pitx3

Z-value: 0.791


Transcription factors associated with Pitx3:

Gene SymbolEntrez IDGene Name
Pitx3 ENSMUSG00000025229.9 Pitx3



Activity profile for motif Pitx3.

activity profile for motif Pitx3


Sorted Z-values histogram for motif Pitx3

Sorted Z-values for motif Pitx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_62899118 9.958 ENSMUST00000174189.1
 Tet1
tet methylcytosine dioxygenase 1
chrX_+_7909542 5.307 ENSMUST00000086274.2
 Gm10490
predicted gene 10490
chr9_+_118506226 4.938 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr1_-_186705980 4.518 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr16_+_17276291 4.343 ENSMUST00000164950.1
ENSMUST00000159242.1
 Tmem191c

transmembrane protein 191C

chr5_+_3571664 4.207 ENSMUST00000008451.5
 1700109H08Rik
RIKEN cDNA 1700109H08 gene
chrX_+_142226765 4.193 ENSMUST00000112916.2
 Nxt2
nuclear transport factor 2-like export factor 2
chr10_+_81718919 3.893 ENSMUST00000085664.5
 Zfp433
RIKEN cDNA 1700123A16 gene
chr4_-_32923455 3.731 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr9_-_15357692 3.667 ENSMUST00000098979.3
ENSMUST00000161132.1
 5830418K08Rik

RIKEN cDNA 5830418K08 gene

chr12_+_51348019 3.622 ENSMUST00000054308.6
 G2e3
G2/M-phase specific E3 ubiquitin ligase
chrX_-_37104523 3.557 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chrX_-_103623648 3.550 ENSMUST00000156211.1
 Ftx
Ftx transcript, Xist regulator (non-protein coding)
chr4_-_86612009 3.422 ENSMUST00000125481.1
ENSMUST00000070607.7
 Haus6

HAUS augmin-like complex, subunit 6

chr5_+_47984793 3.351 ENSMUST00000170109.2
ENSMUST00000174421.1
ENSMUST00000173702.1
ENSMUST00000173107.1
 Slit2



slit homolog 2 (Drosophila)



chr8_+_69300776 3.340 ENSMUST00000078257.6
 D130040H23Rik
RIKEN cDNA D130040H23 gene
chr18_-_10610346 3.325 ENSMUST00000025142.5
 Esco1
establishment of cohesion 1 homolog 1 (S. cerevisiae)
chr2_+_127008711 3.317 ENSMUST00000110394.1
ENSMUST00000002063.8
 Ap4e1

adaptor-related protein complex AP-4, epsilon 1

chr13_-_77131276 3.311 ENSMUST00000159300.1
 Ankrd32
ankyrin repeat domain 32
chr2_-_132578128 3.237 ENSMUST00000028822.7
 Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.8 GO:0001824 blastocyst development(GO:0001824)
2.0 10.0 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
1.5 9.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.1 5.5 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.1 4.9 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.6 4.7 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.9 4.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
1.5 4.5 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.3 3.8 GO:0097502 mannosylation(GO:0097502)
0.1 3.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 3.5 GO:0051225 spindle assembly(GO:0051225)
0.0 3.5 GO:0007601 visual perception(GO:0007601)
1.1 3.4 GO:0042275 error-free postreplication DNA repair(GO:0042275)
1.1 3.4 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.9 3.4 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.7 3.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.5 3.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 3.1 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.7 2.6 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1 2.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 GO:0005604 basement membrane(GO:0005604)
0.1 5.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 5.1 GO:0016605 PML body(GO:0016605)
1.2 3.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.7 3.6 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 3.6 GO:0031616 spindle pole centrosome(GO:0031616)
1.1 3.4 GO:0000802 transverse filament(GO:0000802)
1.1 3.4 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.4 3.4 GO:0070652 HAUS complex(GO:0070652)
0.1 2.9 GO:0043596 nuclear replication fork(GO:0043596)
0.3 2.7 GO:0031415 NatA complex(GO:0031415)
0.2 2.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 2.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.3 2.5 GO:0033269 internode region of axon(GO:0033269)
0.3 2.5 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.2 2.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.5 2.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 2.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.2 GO:0005903 brush border(GO:0005903)
0.3 2.0 GO:0071012 catalytic step 1 spliceosome(GO:0071012)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.7 10.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
2.3 9.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.4 5.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.1 4.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.8 4.0 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.8 3.9 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.2 3.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.9 3.6 GO:0050436 microfibril binding(GO:0050436)
0.1 3.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 3.4 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.1 3.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.2 GO:0002039 p53 binding(GO:0002039)
0.0 3.2 GO:0004386 helicase activity(GO:0004386)
0.0 3.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.9 GO:0017124 SH3 domain binding(GO:0017124)
0.2 2.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.3 2.6 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.8 2.5 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.1 2.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.5 4.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 2.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.3 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 1.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID_FOXO_PATHWAY FoxO family signaling
0.1 1.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 1.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 6.7 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 4.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 4.3 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 3.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 3.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 3.3 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 2.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 2.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 2.6 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 2.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.6 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 2.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.3 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 2.2 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 2.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.0 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis