Motif ID: Pknox2_Pknox1

Z-value: 1.114

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox2mm10_v2_chr9_-_37147257_371473230.309.1e-03Click!
Pknox1mm10_v2_chr17_+_31564749_31564854-0.224.9e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_114795888 13.393 ENSMUST00000000206.3
Btbd17
BTB (POZ) domain containing 17
chr2_+_105682463 11.783 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
Pax6



paired box gene 6



chr1_+_194619815 9.785 ENSMUST00000027952.5
Plxna2
plexin A2
chr2_-_113758638 9.745 ENSMUST00000099575.3
Grem1
gremlin 1
chr17_-_70851189 9.534 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr10_+_41810528 8.856 ENSMUST00000099931.3
Sesn1
sestrin 1
chr7_-_48881032 8.058 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr4_-_155043143 8.035 ENSMUST00000135665.2
Plch2
phospholipase C, eta 2
chr7_-_131410325 7.481 ENSMUST00000154602.1
Ikzf5
IKAROS family zinc finger 5
chr8_-_61902669 7.413 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr7_-_131410495 6.466 ENSMUST00000121033.1
ENSMUST00000046306.8
Ikzf5

IKAROS family zinc finger 5

chr2_-_116065047 6.291 ENSMUST00000028639.6
ENSMUST00000102538.4
Meis2

Meis homeobox 2

chr13_-_58274121 5.898 ENSMUST00000091579.4
Gkap1
G kinase anchoring protein 1
chr19_-_9899450 5.779 ENSMUST00000025562.7
Incenp
inner centromere protein
chrX_-_109013389 5.767 ENSMUST00000033597.8
Hmgn5
high-mobility group nucleosome binding domain 5
chr18_+_49832622 5.353 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr2_-_34913976 5.236 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr9_+_113930934 5.043 ENSMUST00000084885.5
ENSMUST00000009885.7
Ubp1

upstream binding protein 1

chr5_-_138619702 4.826 ENSMUST00000063262.4
Zfp68
zinc finger protein 68
chr5_-_138619751 4.744 ENSMUST00000085852.4
ENSMUST00000110905.2
Zfp68

zinc finger protein 68

chr4_-_3938354 4.719 ENSMUST00000003369.3
Plag1
pleiomorphic adenoma gene 1
chr16_-_11176056 4.717 ENSMUST00000142389.1
ENSMUST00000138185.1
Zc3h7a

zinc finger CCCH type containing 7 A

chr9_-_82975475 4.691 ENSMUST00000034787.5
Phip
pleckstrin homology domain interacting protein
chr5_-_111761697 4.493 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr5_-_138619653 4.480 ENSMUST00000129832.1
Zfp68
zinc finger protein 68
chr9_-_44134481 4.338 ENSMUST00000180670.1
Gm10687
predicted gene 10687
chr1_-_52727457 4.271 ENSMUST00000156876.1
ENSMUST00000087701.3
Mfsd6

major facilitator superfamily domain containing 6

chr10_-_42276688 4.091 ENSMUST00000175881.1
ENSMUST00000056974.3
Foxo3

forkhead box O3

chr9_-_62980874 4.011 ENSMUST00000098651.4
Pias1
protein inhibitor of activated STAT 1
chr10_-_42276744 3.990 ENSMUST00000105502.1
ENSMUST00000105501.1
Foxo3

forkhead box O3

chr14_+_54640952 3.975 ENSMUST00000169818.2
Gm17606
predicted gene, 17606
chr18_-_79109391 3.933 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1

SET binding protein 1

chr9_+_68653761 3.874 ENSMUST00000034766.7
Rora
RAR-related orphan receptor alpha
chr2_-_30415509 3.699 ENSMUST00000134120.1
ENSMUST00000102854.3
Crat

carnitine acetyltransferase

chr3_-_84270782 3.521 ENSMUST00000054990.4
Trim2
tripartite motif-containing 2
chr11_-_80080928 3.366 ENSMUST00000103233.3
ENSMUST00000061283.8
Crlf3

cytokine receptor-like factor 3

chr11_+_23256001 3.232 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
Xpo1



exportin 1, CRM1 homolog (yeast)



chr7_-_48881596 3.212 ENSMUST00000119223.1
E2f8
E2F transcription factor 8
chr17_-_70851710 3.041 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr17_-_24141542 2.994 ENSMUST00000115411.1
ENSMUST00000115409.2
ENSMUST00000115407.2
ENSMUST00000102927.3
Pdpk1



3-phosphoinositide dependent protein kinase 1



chr2_-_160872985 2.985 ENSMUST00000109460.1
ENSMUST00000127201.1
Zhx3

zinc fingers and homeoboxes 3

chr18_+_56432116 2.957 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr5_-_25498702 2.783 ENSMUST00000173073.1
ENSMUST00000045291.7
Kmt2c

lysine (K)-specific methyltransferase 2C

chr15_-_100599864 2.754 ENSMUST00000177247.2
ENSMUST00000177505.2
Pou6f1

POU domain, class 6, transcription factor 1

chr2_-_132578244 2.649 ENSMUST00000110142.1
Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr2_-_132578128 2.636 ENSMUST00000028822.7
Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr9_+_67840386 2.612 ENSMUST00000077879.5
Vps13c
vacuolar protein sorting 13C (yeast)
chr2_-_160872829 2.603 ENSMUST00000176141.1
Zhx3
zinc fingers and homeoboxes 3
chr3_-_51560816 2.565 ENSMUST00000037141.7
Setd7
SET domain containing (lysine methyltransferase) 7
chr3_-_89402650 2.425 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep

lens epithelial protein

chr2_-_30415767 2.369 ENSMUST00000102855.1
ENSMUST00000028207.6
Crat

carnitine acetyltransferase

chr2_-_132578155 2.335 ENSMUST00000110136.1
ENSMUST00000124107.1
ENSMUST00000060955.5
Gpcpd1


glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)


chr3_+_51415986 2.321 ENSMUST00000029303.7
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr11_-_72795801 2.189 ENSMUST00000079681.5
Cyb5d2
cytochrome b5 domain containing 2
chr1_-_58973421 2.139 ENSMUST00000173590.1
ENSMUST00000027186.5
Trak2

trafficking protein, kinesin binding 2

chr10_-_19015347 2.126 ENSMUST00000019997.4
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr5_-_134747241 2.093 ENSMUST00000015138.9
Eln
elastin
chr8_+_3655762 1.995 ENSMUST00000012849.8
ENSMUST00000169234.2
Retn

resistin

chr8_-_69184177 1.965 ENSMUST00000185176.1
Lzts1
leucine zipper, putative tumor suppressor 1
chr5_+_34989473 1.961 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12

regulator of G-protein signaling 12

chr3_+_116594959 1.921 ENSMUST00000029571.8
Sass6
spindle assembly 6 homolog (C. elegans)
chr11_-_72796028 1.889 ENSMUST00000156294.1
Cyb5d2
cytochrome b5 domain containing 2
chr5_-_100500592 1.854 ENSMUST00000149714.1
ENSMUST00000046154.5
Lin54

lin-54 homolog (C. elegans)

chr3_+_95232287 1.847 ENSMUST00000107200.1
ENSMUST00000107199.1
Cdc42se1

CDC42 small effector 1

chr7_+_45434833 1.795 ENSMUST00000003964.8
Gys1
glycogen synthase 1, muscle
chr2_-_91649751 1.779 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chr2_-_91649785 1.767 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr7_+_45434876 1.759 ENSMUST00000107766.1
Gys1
glycogen synthase 1, muscle
chr5_+_93268247 1.753 ENSMUST00000121127.1
Ccng2
cyclin G2
chr5_+_150673739 1.737 ENSMUST00000016569.4
ENSMUST00000038900.8
Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr11_-_49712674 1.721 ENSMUST00000020624.6
ENSMUST00000145353.1
Cnot6

CCR4-NOT transcription complex, subunit 6

chrX_-_102505359 1.689 ENSMUST00000087916.4
Hdac8
histone deacetylase 8
chr15_+_32920723 1.673 ENSMUST00000022871.5
Sdc2
syndecan 2
chr8_-_64693027 1.635 ENSMUST00000048967.7
Cpe
carboxypeptidase E
chr10_+_50592669 1.614 ENSMUST00000035606.8
Ascc3
activating signal cointegrator 1 complex subunit 3
chr19_+_32757497 1.519 ENSMUST00000013807.7
Pten
phosphatase and tensin homolog
chr10_+_7792891 1.424 ENSMUST00000015901.4
Ppil4
peptidylprolyl isomerase (cyclophilin)-like 4
chr17_-_48432723 1.413 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr7_+_25221417 1.380 ENSMUST00000055604.4
Zfp526
zinc finger protein 526
chr2_+_146855861 1.308 ENSMUST00000099278.2
ENSMUST00000156232.1
Plk1s1

polo-like kinase 1 substrate 1

chr11_+_83964419 1.216 ENSMUST00000049714.8
ENSMUST00000092834.5
ENSMUST00000183714.1
ENSMUST00000183456.1
Synrg



synergin, gamma



chr1_+_156558844 1.197 ENSMUST00000166172.2
ENSMUST00000027888.6
Abl2

v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)

chr1_-_74588117 1.159 ENSMUST00000066986.6
Zfp142
zinc finger protein 142
chr10_-_123196916 1.157 ENSMUST00000020334.7
Usp15
ubiquitin specific peptidase 15
chr1_+_156558759 1.150 ENSMUST00000173929.1
Abl2
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
chr13_+_63815240 1.148 ENSMUST00000021926.5
ENSMUST00000095724.3
ENSMUST00000143449.1
ENSMUST00000067821.5
Ercc6l2



excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2



chr8_+_94386486 1.060 ENSMUST00000034220.7
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr10_+_82699007 1.056 ENSMUST00000020478.7
Hcfc2
host cell factor C2
chr10_-_62651194 1.052 ENSMUST00000020270.4
Ddx50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr14_-_30923547 1.050 ENSMUST00000170415.1
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr4_+_3938904 1.000 ENSMUST00000120732.1
ENSMUST00000041122.4
ENSMUST00000121651.1
ENSMUST00000121210.1
ENSMUST00000119307.1
ENSMUST00000123769.1
Chchd7





coiled-coil-helix-coiled-coil-helix domain containing 7





chr16_+_55973881 0.992 ENSMUST00000050248.8
Rpl24
ribosomal protein L24
chr16_-_11909398 0.979 ENSMUST00000127972.1
ENSMUST00000121750.1
ENSMUST00000096272.4
ENSMUST00000073371.6
Cpped1



calcineurin-like phosphoesterase domain containing 1



chr9_-_122294361 0.912 ENSMUST00000042546.2
Ano10
anoctamin 10
chr7_+_89404356 0.868 ENSMUST00000058755.3
Fzd4
frizzled homolog 4 (Drosophila)
chr1_-_36244245 0.840 ENSMUST00000046875.7
Uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr4_+_11758147 0.831 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr11_+_3202908 0.823 ENSMUST00000179770.1
ENSMUST00000110048.1
Eif4enif1

eukaryotic translation initiation factor 4E nuclear import factor 1

chr2_-_130582554 0.794 ENSMUST00000046001.6
Avp
arginine vasopressin
chr9_+_21424901 0.761 ENSMUST00000165766.2
ENSMUST00000173397.1
ENSMUST00000072362.7
ENSMUST00000091087.6
ENSMUST00000115404.4
Dnm2




dynamin 2




chr3_+_107631322 0.748 ENSMUST00000106703.1
Gm10961
predicted gene 10961
chr13_-_12106945 0.733 ENSMUST00000021750.7
ENSMUST00000170156.2
Ryr2

ryanodine receptor 2, cardiac

chr7_+_98703091 0.695 ENSMUST00000033009.9
Prkrir
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr2_-_31141802 0.690 ENSMUST00000073879.5
ENSMUST00000100208.2
ENSMUST00000100207.2
ENSMUST00000113555.1
ENSMUST00000075326.4
ENSMUST00000113552.2
ENSMUST00000136181.1
Fnbp1






formin binding protein 1






chr7_-_126584220 0.664 ENSMUST00000128970.1
ENSMUST00000116269.2
Cln3

ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)

chr4_+_3938888 0.656 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr6_+_95117740 0.637 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr9_+_21424984 0.629 ENSMUST00000172482.1
ENSMUST00000174050.1
Dnm2

dynamin 2

chr7_+_13398115 0.617 ENSMUST00000005791.7
Cabp5
calcium binding protein 5
chrX_-_60893430 0.573 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr2_+_128967383 0.544 ENSMUST00000110320.2
ENSMUST00000110319.2
Zc3h6

zinc finger CCCH type containing 6

chr1_+_134182150 0.525 ENSMUST00000156873.1
Chi3l1
chitinase 3-like 1
chr16_-_96127604 0.508 ENSMUST00000133885.1
ENSMUST00000050884.7
Hmgn1

high mobility group nucleosomal binding domain 1

chr7_+_105554360 0.463 ENSMUST00000046983.8
Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr1_+_134182404 0.457 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
Chi3l1



chitinase 3-like 1



chr17_-_66077022 0.436 ENSMUST00000150766.1
ENSMUST00000038116.5
Ankrd12

ankyrin repeat domain 12

chr8_+_25601591 0.429 ENSMUST00000155861.1
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr1_+_179546303 0.429 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr19_+_6047081 0.405 ENSMUST00000025723.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr15_-_59374149 0.343 ENSMUST00000022976.4
E430025E21Rik
RIKEN cDNA E430025E21 gene
chr5_+_34761734 0.307 ENSMUST00000080036.2
Htt
huntingtin
chr16_-_91069142 0.276 ENSMUST00000035689.1
ENSMUST00000114076.1
4932438H23Rik

RIKEN cDNA 4932438H23 gene

chr19_+_6047055 0.264 ENSMUST00000134667.1
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr16_-_43979050 0.163 ENSMUST00000165648.1
ENSMUST00000036321.7
Zdhhc23

zinc finger, DHHC domain containing 23

chr4_+_141444654 0.139 ENSMUST00000006377.6
Zbtb17
zinc finger and BTB domain containing 17
chr15_-_76723814 0.132 ENSMUST00000036247.8
C030006K11Rik
RIKEN cDNA C030006K11 gene
chr11_-_46312220 0.110 ENSMUST00000129474.1
ENSMUST00000093166.4
ENSMUST00000165599.2
Cyfip2


cytoplasmic FMR1 interacting protein 2


chr9_-_71771535 0.090 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
Cgnl1


cingulin-like 1


chr3_+_137864487 0.021 ENSMUST00000041045.7
H2afz
H2A histone family, member Z
chr11_+_117986292 0.017 ENSMUST00000132676.1
Pgs1
phosphatidylglycerophosphate synthase 1
chr5_+_44100442 0.012 ENSMUST00000072800.4
Gm16401
predicted gene 16401
chr1_-_179546261 0.006 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
3.2 9.7 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
2.4 11.8 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.3 7.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.2 8.1 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
1.1 9.8 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.9 6.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.8 12.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 5.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.7 2.1 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.6 5.4 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.6 2.9 GO:0042701 progesterone secretion(GO:0042701)
0.6 1.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.6 8.9 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.5 1.6 GO:0030070 insulin processing(GO:0030070)
0.5 1.5 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.5 1.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 4.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.5 1.4 GO:1903406 regulation of sodium:potassium-exchanging ATPase activity(GO:1903406)
0.4 2.6 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.4 0.8 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.4 3.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.4 2.0 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.4 7.4 GO:0003334 keratinocyte development(GO:0003334)
0.4 4.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.4 4.7 GO:0060736 prostate gland growth(GO:0060736)
0.3 1.7 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.3 2.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.3 2.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.3 3.9 GO:0036315 cellular response to sterol(GO:0036315) regulation of cholesterol homeostasis(GO:2000188)
0.3 2.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 0.8 GO:0007621 negative regulation of female receptivity(GO:0007621) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of cellular pH reduction(GO:0032847) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.3 0.5 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.2 1.0 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.2 0.7 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.2 2.1 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.2 1.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 1.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.2 1.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.2 0.7 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.2 3.0 GO:0006972 hyperosmotic response(GO:0006972) negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.2 2.8 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 0.4 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 1.4 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.1 0.5 GO:0023021 termination of signal transduction(GO:0023021)
0.1 0.3 GO:1904580 quinolinate biosynthetic process(GO:0019805) regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504) regulation of intracellular mRNA localization(GO:1904580)
0.1 3.5 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.1 6.3 GO:0008542 visual learning(GO:0008542)
0.1 5.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 2.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.1 5.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 13.1 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 1.1 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.6 GO:0014029 neural crest formation(GO:0014029)
0.1 1.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 3.6 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 5.9 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187)
0.1 1.9 GO:0007099 centriole replication(GO:0007099)
0.1 0.8 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 1.8 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 5.8 GO:0000910 cytokinesis(GO:0000910)
0.0 1.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.6 GO:0007530 sex determination(GO:0007530)
0.0 0.7 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 1.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 2.1 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 3.6 GO:0016042 lipid catabolic process(GO:0016042)
0.0 1.7 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 2.3 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.9 GO:0006821 chloride transport(GO:0006821)
0.0 4.1 GO:0045666 positive regulation of neuron differentiation(GO:0045666)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0000801 central element(GO:0000801)
0.7 8.6 GO:0061700 GATOR2 complex(GO:0061700)
0.7 2.1 GO:0071953 elastic fiber(GO:0071953)
0.3 1.9 GO:0098536 deuterosome(GO:0098536)
0.3 3.2 GO:0005642 annulate lamellae(GO:0005642)
0.3 2.3 GO:0031415 NatA complex(GO:0031415)
0.2 2.8 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 1.1 GO:1990037 Lewy body core(GO:1990037)
0.2 5.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 3.7 GO:0001891 phagocytic cup(GO:0001891)
0.2 1.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.2 7.4 GO:0002102 podosome(GO:0002102)
0.1 0.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 1.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.1 1.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 2.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 20.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.7 GO:0016605 PML body(GO:0016605)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 6.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 7.4 GO:0005938 cell cortex(GO:0005938)
0.0 2.0 GO:0016234 inclusion body(GO:0016234)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 11.4 GO:0016604 nuclear body(GO:0016604)
0.0 2.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 29.3 GO:0005654 nucleoplasm(GO:0005654)
0.0 0.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.7 GO:0005776 autophagosome(GO:0005776)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.6 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
1.5 6.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
1.5 8.9 GO:0070728 leucine binding(GO:0070728)
1.1 24.4 GO:0070410 co-SMAD binding(GO:0070410)
1.1 9.7 GO:0036122 BMP binding(GO:0036122)
1.0 3.9 GO:0008142 oxysterol binding(GO:0008142)
0.7 9.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.6 4.0 GO:0061665 SUMO ligase activity(GO:0061665)
0.5 1.5 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.5 4.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.4 8.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.4 1.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.3 3.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 2.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 3.0 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.3 0.8 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.2 0.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.2 0.8 GO:0031893 vasopressin receptor binding(GO:0031893)
0.2 1.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.2 4.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 1.6 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.2 1.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 2.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 2.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 6.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.4 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 8.2 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 2.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 27.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 2.6 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 1.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 5.2 GO:0035064 methylated histone binding(GO:0035064)
0.1 4.1 GO:0020037 heme binding(GO:0020037)
0.1 0.4 GO:0071253 connexin binding(GO:0071253)
0.1 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 3.5 GO:0017022 myosin binding(GO:0017022)
0.0 2.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0034452 dynactin binding(GO:0034452)
0.0 0.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 6.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 6.3 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.7 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 8.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 9.7 PID_BMP_PATHWAY BMP receptor signaling
0.2 4.5 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 12.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 5.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 11.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.9 PID_CDC42_PATHWAY CDC42 signaling events
0.1 2.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 9.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 3.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 4.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 11.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.6 9.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.4 12.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 8.1 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.3 4.0 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.2 3.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 6.1 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.2 3.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 4.5 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.1 0.8 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 2.0 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 2.1 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 1.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.7 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.6 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 0.8 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 5.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.7 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.0 3.2 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism