Motif ID: Pknox2_Pknox1

Z-value: 1.114

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox2mm10_v2_chr9_-_37147257_371473230.309.1e-03Click!
Pknox1mm10_v2_chr17_+_31564749_31564854-0.224.9e-02Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_114795888 13.393 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17
chr2_+_105682463 11.783 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr1_+_194619815 9.785 ENSMUST00000027952.5
 Plxna2
plexin A2
chr2_-_113758638 9.745 ENSMUST00000099575.3
 Grem1
gremlin 1
chr17_-_70851189 9.534 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr10_+_41810528 8.856 ENSMUST00000099931.3
 Sesn1
sestrin 1
chr7_-_48881032 8.058 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr4_-_155043143 8.035 ENSMUST00000135665.2
 Plch2
phospholipase C, eta 2
chr7_-_131410325 7.481 ENSMUST00000154602.1
 Ikzf5
IKAROS family zinc finger 5
chr8_-_61902669 7.413 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr7_-_131410495 6.466 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr2_-_116065047 6.291 ENSMUST00000028639.6
ENSMUST00000102538.4
 Meis2

Meis homeobox 2

chr13_-_58274121 5.898 ENSMUST00000091579.4
 Gkap1
G kinase anchoring protein 1
chr19_-_9899450 5.779 ENSMUST00000025562.7
 Incenp
inner centromere protein
chrX_-_109013389 5.767 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr18_+_49832622 5.353 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr2_-_34913976 5.236 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr9_+_113930934 5.043 ENSMUST00000084885.5
ENSMUST00000009885.7
 Ubp1

upstream binding protein 1

chr5_-_138619702 4.826 ENSMUST00000063262.4
 Zfp68
zinc finger protein 68
chr5_-_138619751 4.744 ENSMUST00000085852.4
ENSMUST00000110905.2
 Zfp68

zinc finger protein 68


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.1 GO:0051291 protein heterooligomerization(GO:0051291)
0.8 12.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.4 11.8 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
3.8 11.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.1 9.8 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
3.2 9.7 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.6 8.9 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
1.2 8.1 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
1.3 7.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.4 7.4 GO:0003334 keratinocyte development(GO:0003334)
0.1 6.3 GO:0008542 visual learning(GO:0008542)
0.9 6.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 5.9 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187)
0.1 5.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 5.8 GO:0000910 cytokinesis(GO:0000910)
0.1 5.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.6 5.4 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.7 5.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.5 4.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.4 4.7 GO:0060736 prostate gland growth(GO:0060736)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.3 GO:0005654 nucleoplasm(GO:0005654)
0.0 20.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 11.4 GO:0016604 nuclear body(GO:0016604)
0.7 8.6 GO:0061700 GATOR2 complex(GO:0061700)
0.2 7.4 GO:0002102 podosome(GO:0002102)
0.0 7.4 GO:0005938 cell cortex(GO:0005938)
0.0 6.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.9 5.8 GO:0000801 central element(GO:0000801)
0.2 5.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 3.7 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.7 GO:0016605 PML body(GO:0016605)
0.3 3.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 3.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.8 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.3 2.3 GO:0031415 NatA complex(GO:0031415)
0.7 2.1 GO:0071953 elastic fiber(GO:0071953)
0.1 2.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.0 GO:0016234 inclusion body(GO:0016234)
0.3 1.9 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.1 24.4 GO:0070410 co-SMAD binding(GO:0070410)
0.7 9.8 GO:0017154 semaphorin receptor activity(GO:0017154)
1.1 9.7 GO:0036122 BMP binding(GO:0036122)
1.5 8.9 GO:0070728 leucine binding(GO:0070728)
0.1 8.2 GO:0001221 transcription cofactor binding(GO:0001221)
0.4 8.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
1.9 7.6 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 6.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 6.3 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 6.2 GO:0003714 transcription corepressor activity(GO:0003714)
1.5 6.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 5.2 GO:0035064 methylated histone binding(GO:0035064)
0.2 4.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.5 4.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 4.1 GO:0020037 heme binding(GO:0020037)
0.6 4.0 GO:0061665 SUMO ligase activity(GO:0061665)
1.0 3.9 GO:0008142 oxysterol binding(GO:0008142)
0.1 3.5 GO:0017022 myosin binding(GO:0017022)
0.3 3.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 11.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 9.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 9.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 8.9 PID_CDC42_PATHWAY CDC42 signaling events
0.3 8.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.4 7.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 5.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 4.5 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 4.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 3.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.5 PID_TRAIL_PATHWAY TRAIL signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.8 11.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.6 9.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.4 8.1 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.2 6.1 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 5.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.5 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.3 4.0 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.2 3.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 3.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 3.2 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 2.7 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.1 2.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.1 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 2.0 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 2.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 1.7 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 1.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.6 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing