Motif ID: Plag1

Z-value: 0.676


Transcription factors associated with Plag1:

Gene SymbolEntrez IDGene Name
Plag1 ENSMUSG00000003282.3 Plag1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plag1mm10_v2_chr4_-_3938354_3938401-0.216.5e-02Click!


Activity profile for motif Plag1.

activity profile for motif Plag1


Sorted Z-values histogram for motif Plag1

Sorted Z-values for motif Plag1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plag1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 5.292 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr6_-_48841373 2.619 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr1_-_172057573 2.347 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr6_-_48841098 2.276 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr9_+_54764748 2.195 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I
chr10_-_102490418 2.117 ENSMUST00000020040.3
 Nts
neurotensin
chr11_+_69632927 2.080 ENSMUST00000018909.3
 Fxr2
fragile X mental retardation, autosomal homolog 2
chr18_+_82914632 1.993 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr17_+_72918298 1.948 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr6_-_48840988 1.854 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr15_-_84856043 1.811 ENSMUST00000159939.1
 Phf21b
PHD finger protein 21B
chr11_+_77930800 1.789 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr4_-_66404512 1.686 ENSMUST00000068214.4
 Astn2
astrotactin 2
chr7_-_127026479 1.672 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr3_+_94933041 1.651 ENSMUST00000090839.5
 Selenbp1
selenium binding protein 1
chr11_+_101468164 1.620 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr4_-_63403330 1.616 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr3_+_94693556 1.604 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr10_+_80150448 1.529 ENSMUST00000153477.1
 Midn
midnolin
chr8_-_87959560 1.499 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 371 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.3 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 4.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.7 4.4 GO:0048105 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.2 3.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.5 2.9 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 2.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 2.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.9 2.6 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.4 2.5 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.7 2.2 GO:0016115 terpenoid catabolic process(GO:0016115)
0.3 2.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 2.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.4 2.1 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.4 2.1 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.1 2.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 2.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.6 1.9 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.3 1.9 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 1.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.6 1.8 GO:0097402 neuroblast migration(GO:0097402)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0060170 ciliary membrane(GO:0060170)
0.0 4.9 GO:0005667 transcription factor complex(GO:0005667)
1.1 4.4 GO:0060187 cell pole(GO:0060187)
0.1 3.9 GO:0032590 dendrite membrane(GO:0032590)
0.2 3.7 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.1 3.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 3.0 GO:0072562 blood microparticle(GO:0072562)
0.6 2.5 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 2.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.1 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 2.0 GO:0031105 septin complex(GO:0031105)
0.1 2.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.8 GO:0005769 early endosome(GO:0005769)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.6 1.7 GO:0036125 mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125)
0.1 1.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 248 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 5.7 GO:0003735 structural constituent of ribosome(GO:0003735)
1.8 5.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 5.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 3.3 GO:0008430 selenium binding(GO:0008430)
1.0 2.9 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.4 2.5 GO:0019841 retinol binding(GO:0019841)
0.0 2.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.6 1.9 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.5 1.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 1.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.9 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 1.9 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 1.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.4 1.7 GO:0016508 long-chain-enoyl-CoA hydratase activity(GO:0016508) long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.2 1.7 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 1.7 GO:0030332 cyclin binding(GO:0030332)
0.4 1.6 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.3 1.6 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 4.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.6 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 2.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 1.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.5 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 1.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 1.3 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 1.3 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 3.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.7 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 2.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 2.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 2.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 2.0 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 1.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.6 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 1.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 1.5 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.0 1.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.5 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane