Motif ID: Plagl1

Z-value: 0.785


Transcription factors associated with Plagl1:

Gene SymbolEntrez IDGene Name
Plagl1 ENSMUSG00000019817.12 Plagl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plagl1mm10_v2_chr10_+_13090788_13090843-0.606.1e-09Click!


Activity profile for motif Plagl1.

activity profile for motif Plagl1


Sorted Z-values histogram for motif Plagl1

Sorted Z-values for motif Plagl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plagl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_91807424 11.881 ENSMUST00000162300.1
Grip2
glutamate receptor interacting protein 2
chr6_-_91807318 10.719 ENSMUST00000159684.1
Grip2
glutamate receptor interacting protein 2
chr17_+_46297406 8.948 ENSMUST00000061722.6
ENSMUST00000166280.1
Dlk2

delta-like 2 homolog (Drosophila)

chr4_+_47288057 8.626 ENSMUST00000140413.1
ENSMUST00000107731.2
Col15a1

collagen, type XV, alpha 1

chr2_-_104257400 8.493 ENSMUST00000141159.1
D430041D05Rik
RIKEN cDNA D430041D05 gene
chr4_-_139092958 7.994 ENSMUST00000042844.6
Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr4_+_152338619 7.770 ENSMUST00000030775.5
ENSMUST00000164662.1
Chd5

chromodomain helicase DNA binding protein 5

chr17_-_24644933 6.885 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr10_+_38965515 6.702 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr3_+_26331150 6.540 ENSMUST00000099182.2
A830092H15Rik
RIKEN cDNA A830092H15 gene
chr5_-_139130159 6.104 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr4_+_47288287 5.849 ENSMUST00000146967.1
Col15a1
collagen, type XV, alpha 1
chr17_+_46297917 5.846 ENSMUST00000166617.1
ENSMUST00000170271.1
Dlk2

delta-like 2 homolog (Drosophila)

chr9_+_75625707 5.538 ENSMUST00000034702.4
Lysmd2
LysM, putative peptidoglycan-binding, domain containing 2
chr19_+_6497772 5.424 ENSMUST00000113458.1
ENSMUST00000113459.1
Nrxn2

neurexin II

chr7_-_99695809 5.409 ENSMUST00000107086.2
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr5_-_136567242 4.927 ENSMUST00000175975.2
ENSMUST00000176216.2
ENSMUST00000176745.1
Cux1


cut-like homeobox 1


chr6_+_4504814 4.820 ENSMUST00000141483.1
Col1a2
collagen, type I, alpha 2
chr6_+_110645572 4.648 ENSMUST00000071076.6
ENSMUST00000172951.1
Grm7

glutamate receptor, metabotropic 7

chr3_-_108017877 4.594 ENSMUST00000004140.4
Gstm1
glutathione S-transferase, mu 1
chr11_-_120047144 4.526 ENSMUST00000103020.1
Aatk
apoptosis-associated tyrosine kinase
chr3_-_108017806 4.442 ENSMUST00000126593.1
Gstm1
glutathione S-transferase, mu 1
chr11_+_98741871 4.184 ENSMUST00000103139.4
Thra
thyroid hormone receptor alpha
chr11_+_98741805 3.853 ENSMUST00000064187.5
Thra
thyroid hormone receptor alpha
chr18_-_38601268 3.664 ENSMUST00000025295.6
Spry4
sprouty homolog 4 (Drosophila)
chr5_+_125475814 3.495 ENSMUST00000031445.3
Aacs
acetoacetyl-CoA synthetase
chr6_-_128200598 3.415 ENSMUST00000071101.6
Gm10010
predicted gene 10010
chr6_-_128143525 3.396 ENSMUST00000032503.5
ENSMUST00000112173.1
Tspan9

tetraspanin 9

chr6_-_92481343 3.334 ENSMUST00000113445.1
Prickle2
prickle homolog 2 (Drosophila)
chr13_+_5861489 3.325 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr10_-_81482655 3.208 ENSMUST00000120508.1
ENSMUST00000118763.1
Celf5

CUGBP, Elav-like family member 5

chr15_+_75993756 2.983 ENSMUST00000089669.4
Mapk15
mitogen-activated protein kinase 15
chr7_+_142533012 2.963 ENSMUST00000038675.6
Mrpl23
mitochondrial ribosomal protein L23
chr5_-_34187670 2.881 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chrX_-_73824938 2.680 ENSMUST00000114438.2
ENSMUST00000002080.5
Pdzd4

PDZ domain containing 4

chr12_-_103443653 2.662 ENSMUST00000055071.8
Ifi27l2a
interferon, alpha-inducible protein 27 like 2A
chr5_-_136883115 2.609 ENSMUST00000057497.6
ENSMUST00000111103.1
Col26a1

collagen, type XXVI, alpha 1

chr16_+_91406235 2.601 ENSMUST00000023691.5
Il10rb
interleukin 10 receptor, beta
chr1_-_88205674 2.489 ENSMUST00000119972.2
Dnajb3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr11_+_70018421 2.441 ENSMUST00000108588.1
Dlg4
discs, large homolog 4 (Drosophila)
chr10_-_81014902 2.378 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr18_+_32377176 2.338 ENSMUST00000091967.5
ENSMUST00000025239.7
Bin1

bridging integrator 1

chr8_+_93810832 2.306 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr2_-_132145057 2.231 ENSMUST00000028815.8
Slc23a2
solute carrier family 23 (nucleobase transporters), member 2
chr17_+_25016343 2.171 ENSMUST00000024983.5
Ift140
intraflagellar transport 140
chr1_-_120074023 2.147 ENSMUST00000056089.7
Tmem37
transmembrane protein 37
chr6_+_40325471 2.055 ENSMUST00000031977.8
Agk
acylglycerol kinase
chr11_+_32455362 2.025 ENSMUST00000051053.4
Ubtd2
ubiquitin domain containing 2
chrX_-_75874536 1.983 ENSMUST00000033547.7
Pls3
plastin 3 (T-isoform)
chr17_-_25868727 1.944 ENSMUST00000026828.5
Fam195a
family with sequence similarity 195, member A
chr5_+_24393640 1.855 ENSMUST00000138168.1
ENSMUST00000115077.1
Abcb8

ATP-binding cassette, sub-family B (MDR/TAP), member 8

chr4_+_106561027 1.829 ENSMUST00000047973.3
Dhcr24
24-dehydrocholesterol reductase
chr4_+_155249960 1.781 ENSMUST00000178473.1
ENSMUST00000105627.1
ENSMUST00000097747.2
2610002J02Rik


RIKEN cDNA 2610002J02 gene


chr2_-_130642770 1.736 ENSMUST00000045761.6
Lzts3
leucine zipper, putative tumor suppressor family member 3
chr19_+_5474681 1.714 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr4_+_129136948 1.704 ENSMUST00000102600.3
Fndc5
fibronectin type III domain containing 5
chr19_+_45047557 1.641 ENSMUST00000062213.5
ENSMUST00000111954.4
ENSMUST00000084493.6
Sfxn3


sideroflexin 3


chr2_-_152332639 1.476 ENSMUST00000028964.7
Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_+_101496648 1.447 ENSMUST00000106930.1
ENSMUST00000154120.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr19_+_4711153 1.419 ENSMUST00000008991.6
Sptbn2
spectrin beta, non-erythrocytic 2
chr17_+_29549783 1.371 ENSMUST00000048677.7
Tbc1d22b
TBC1 domain family, member 22B
chr1_+_74588347 1.280 ENSMUST00000113732.1
Bcs1l
BCS1-like (yeast)
chr15_-_43869993 1.278 ENSMUST00000067469.4
Tmem74
transmembrane protein 74
chr12_+_100199435 1.262 ENSMUST00000110082.3
Calm1
calmodulin 1
chr2_-_152831112 1.185 ENSMUST00000128172.1
Bcl2l1
BCL2-like 1
chr19_-_4625612 1.170 ENSMUST00000025823.3
Rce1
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chr1_+_74588289 1.162 ENSMUST00000113733.3
ENSMUST00000027358.4
Bcs1l

BCS1-like (yeast)

chr8_-_25101985 1.149 ENSMUST00000128715.1
ENSMUST00000064883.6
Plekha2

pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2

chr7_+_45872772 1.094 ENSMUST00000002855.5
ENSMUST00000107719.1
Kdelr1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

chr5_-_92083455 1.091 ENSMUST00000169094.1
ENSMUST00000167918.1
G3bp2

GTPase activating protein (SH3 domain) binding protein 2

chr11_+_67966442 1.014 ENSMUST00000021286.4
ENSMUST00000108675.1
Stx8

syntaxin 8

chr6_+_124712279 0.994 ENSMUST00000004375.9
Phb2
prohibitin 2
chr5_-_143269958 0.989 ENSMUST00000161448.1
Zfp316
zinc finger protein 316
chr1_-_179546261 0.942 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chrX_+_99821021 0.924 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr12_+_110889231 0.879 ENSMUST00000169597.1
ENSMUST00000165978.1
Tecpr2

tectonin beta-propeller repeat containing 2

chr5_-_92083667 0.858 ENSMUST00000113127.3
G3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr10_+_80016901 0.847 ENSMUST00000105373.1
Hmha1
histocompatibility (minor) HA-1
chr10_-_70599284 0.819 ENSMUST00000046513.3
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr9_+_46273064 0.811 ENSMUST00000156440.1
ENSMUST00000034583.6
ENSMUST00000114552.3
Zfp259


zinc finger protein 259


chr2_-_3419066 0.778 ENSMUST00000115082.3
Meig1
meiosis expressed gene 1
chr5_-_24577467 0.766 ENSMUST00000030795.8
Abcf2
ATP-binding cassette, sub-family F (GCN20), member 2
chr16_+_32277449 0.757 ENSMUST00000155649.1
ENSMUST00000014218.8
ENSMUST00000171474.1
Rnf168


ring finger protein 168


chr6_-_48086530 0.739 ENSMUST00000073124.6
Zfp746
zinc finger protein 746
chr4_+_148160613 0.711 ENSMUST00000047951.8
Fbxo2
F-box protein 2
chr6_+_83179568 0.654 ENSMUST00000113919.3
ENSMUST00000113918.1
ENSMUST00000141680.1
Dctn1


dynactin 1


chr8_-_13974715 0.634 ENSMUST00000119182.1
ENSMUST00000062613.4
Tdrp

testis development related protein

chr2_-_152830615 0.622 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
Bcl2l1



BCL2-like 1



chr15_-_52478228 0.618 ENSMUST00000081993.1
Gm10020
predicted pseudogene 10020
chr2_+_25428699 0.600 ENSMUST00000102919.3
Abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr12_-_69893162 0.541 ENSMUST00000049239.7
ENSMUST00000110570.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr11_-_33843405 0.535 ENSMUST00000101368.2
Kcnip1
Kv channel-interacting protein 1
chr7_+_5015466 0.469 ENSMUST00000086349.3
Zfp524
zinc finger protein 524
chr9_+_108662098 0.458 ENSMUST00000035222.5
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chrX_-_37085402 0.455 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chrX_+_163911401 0.428 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr10_-_95415484 0.422 ENSMUST00000172070.1
ENSMUST00000150432.1
Socs2

suppressor of cytokine signaling 2

chr2_-_18998126 0.422 ENSMUST00000006912.5
Pip4k2a
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr17_+_37193889 0.409 ENSMUST00000038844.6
Ubd
ubiquitin D
chr15_-_99251929 0.388 ENSMUST00000041190.9
ENSMUST00000163506.1
Mcrs1

microspherule protein 1

chr11_-_33843526 0.366 ENSMUST00000065970.5
ENSMUST00000109340.2
Kcnip1

Kv channel-interacting protein 1

chr11_+_87699897 0.351 ENSMUST00000040089.4
Rnf43
ring finger protein 43
chr1_+_179546303 0.332 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr1_+_134455524 0.317 ENSMUST00000112232.1
ENSMUST00000027725.4
ENSMUST00000116528.1
Klhl12


kelch-like 12


chr2_-_3419019 0.305 ENSMUST00000115084.1
ENSMUST00000115083.1
Meig1

meiosis expressed gene 1

chr8_-_40634750 0.274 ENSMUST00000173957.1
Mtmr7
myotubularin related protein 7
chr2_-_65567465 0.256 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr2_-_65567505 0.199 ENSMUST00000100069.2
Scn3a
sodium channel, voltage-gated, type III, alpha
chrX_+_20870166 0.183 ENSMUST00000115342.3
ENSMUST00000009530.4
Timp1

tissue inhibitor of metalloproteinase 1

chr16_+_32099781 0.147 ENSMUST00000115168.2
Cep19
centrosomal protein 19
chr6_-_124712131 0.134 ENSMUST00000004379.5
Emg1
EMG1 nucleolar protein homolog (S. cerevisiae)
chr12_+_99884498 0.123 ENSMUST00000153627.1
Tdp1
tyrosyl-DNA phosphodiesterase 1
chr6_+_67266979 0.067 ENSMUST00000042990.4
Serbp1
serpine1 mRNA binding protein 1
chr12_-_15816762 0.048 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr11_+_95010277 0.031 ENSMUST00000124735.1
Samd14
sterile alpha motif domain containing 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
2.3 22.6 GO:0014824 artery smooth muscle contraction(GO:0014824)
2.0 8.0 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
1.1 3.3 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
1.1 7.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.9 4.6 GO:0001661 conditioned taste aversion(GO:0001661)
0.7 2.2 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.5 9.0 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.5 6.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5 5.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 1.8 GO:0046898 response to cycloheximide(GO:0046898)
0.4 4.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.4 4.8 GO:0043589 skin morphogenesis(GO:0043589)
0.4 14.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 6.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.3 5.4 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.3 0.8 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.2 2.4 GO:2000821 regulation of grooming behavior(GO:2000821)
0.2 2.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.2 1.4 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 2.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.2 8.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 2.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.2 1.5 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.2 2.3 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.2 1.8 GO:0031639 plasminogen activation(GO:0031639)
0.2 1.0 GO:0060744 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.2 1.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.9 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 2.0 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.9 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.7 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.1 4.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 3.0 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 0.3 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 0.5 GO:0046684 response to pyrethroid(GO:0046684)
0.1 0.6 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 0.4 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.1 1.9 GO:0034063 stress granule assembly(GO:0034063)
0.1 3.5 GO:0070542 response to fatty acid(GO:0070542)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.5 GO:0015879 carnitine transport(GO:0015879)
0.1 1.4 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.1 2.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 3.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 2.1 GO:0046834 lipid phosphorylation(GO:0046834)
0.1 3.7 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 3.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.3 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.4 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.7 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.9 GO:0045760 positive regulation of action potential(GO:0045760)
0.0 0.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.4 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045) negative regulation of trophoblast cell migration(GO:1901164) negative regulation of metallopeptidase activity(GO:1905049)
0.0 3.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.0 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 4.8 GO:0009615 response to virus(GO:0009615)
0.0 1.3 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.0 0.2 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 1.6 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 1.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.0 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 3.4 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.4 GO:0060612 adipose tissue development(GO:0060612)
0.0 2.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 11.5 GO:0007155 cell adhesion(GO:0007155)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0005584 collagen type I trimer(GO:0005584)
0.5 6.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 4.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.4 3.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 1.5 GO:0071797 LUBAC complex(GO:0071797)
0.3 7.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 6.7 GO:0005605 basal lamina(GO:0005605)
0.3 17.1 GO:0005581 collagen trimer(GO:0005581)
0.2 2.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.2 1.4 GO:0008091 spectrin(GO:0008091)
0.2 22.6 GO:0043198 dendritic shaft(GO:0043198)
0.2 8.9 GO:0032420 stereocilium(GO:0032420)
0.2 3.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 1.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 3.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 7.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 4.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 4.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 5.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 4.2 GO:0044295 axonal growth cone(GO:0044295)
0.1 3.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.7 GO:0005869 dynactin complex(GO:0005869)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 3.5 GO:0001650 fibrillar center(GO:0001650)
0.0 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.3 GO:0043209 myelin sheath(GO:0043209)
0.0 2.4 GO:0043197 dendritic spine(GO:0043197)
0.0 4.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.6 GO:0031966 mitochondrial membrane(GO:0031966)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
2.7 8.0 GO:0016015 morphogen activity(GO:0016015)
1.9 7.8 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
1.5 4.6 GO:0070905 serine binding(GO:0070905)
0.9 3.5 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.8 9.0 GO:0016151 nickel cation binding(GO:0016151)
0.8 5.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.7 2.2 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.7 2.1 GO:0001729 ceramide kinase activity(GO:0001729)
0.6 6.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 2.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.4 2.3 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3 4.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 1.3 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.3 0.9 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.3 2.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.3 1.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.3 22.6 GO:0035254 glutamate receptor binding(GO:0035254)
0.2 0.9 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 1.8 GO:0051434 BH3 domain binding(GO:0051434)
0.2 6.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 3.0 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 1.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 5.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.5 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 2.0 GO:0048156 tau protein binding(GO:0048156)
0.1 4.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.8 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 1.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 19.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 17.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 2.1 GO:0005262 calcium channel activity(GO:0005262)
0.0 4.5 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 1.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 1.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.2 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 21.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 7.4 NABA_COLLAGENS Genes encoding collagen proteins
0.2 8.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 6.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 6.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 1.8 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 8.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.5 PID_TNF_PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 22.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.7 5.4 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.4 4.8 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 4.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 7.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 6.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 14.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 4.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.6 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 1.8 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 8.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.4 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 2.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases