Motif ID: Plagl1

Z-value: 0.785


Transcription factors associated with Plagl1:

Gene SymbolEntrez IDGene Name
Plagl1 ENSMUSG00000019817.12 Plagl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plagl1mm10_v2_chr10_+_13090788_13090843-0.606.1e-09Click!


Activity profile for motif Plagl1.

activity profile for motif Plagl1


Sorted Z-values histogram for motif Plagl1

Sorted Z-values for motif Plagl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plagl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_91807424 11.881 ENSMUST00000162300.1
 Grip2
glutamate receptor interacting protein 2
chr6_-_91807318 10.719 ENSMUST00000159684.1
 Grip2
glutamate receptor interacting protein 2
chr17_+_46297406 8.948 ENSMUST00000061722.6
ENSMUST00000166280.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr4_+_47288057 8.626 ENSMUST00000140413.1
ENSMUST00000107731.2
 Col15a1

collagen, type XV, alpha 1

chr2_-_104257400 8.493 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr4_-_139092958 7.994 ENSMUST00000042844.6
 Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr4_+_152338619 7.770 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr17_-_24644933 6.885 ENSMUST00000019684.5
 Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr10_+_38965515 6.702 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr3_+_26331150 6.540 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr5_-_139130159 6.104 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr4_+_47288287 5.849 ENSMUST00000146967.1
 Col15a1
collagen, type XV, alpha 1
chr17_+_46297917 5.846 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr9_+_75625707 5.538 ENSMUST00000034702.4
 Lysmd2
LysM, putative peptidoglycan-binding, domain containing 2
chr19_+_6497772 5.424 ENSMUST00000113458.1
ENSMUST00000113459.1
 Nrxn2

neurexin II

chr7_-_99695809 5.409 ENSMUST00000107086.2
 Slco2b1
solute carrier organic anion transporter family, member 2b1
chr5_-_136567242 4.927 ENSMUST00000175975.2
ENSMUST00000176216.2
ENSMUST00000176745.1
 Cux1


cut-like homeobox 1


chr6_+_4504814 4.820 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr6_+_110645572 4.648 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr3_-_108017877 4.594 ENSMUST00000004140.4
 Gstm1
glutathione S-transferase, mu 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 22.6 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.4 14.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 11.5 GO:0007155 cell adhesion(GO:0007155)
0.5 9.0 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.2 8.4 GO:0050873 brown fat cell differentiation(GO:0050873)
2.7 8.0 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
2.0 8.0 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
1.1 7.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.5 6.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 6.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.5 5.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 5.4 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.1 4.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.4 4.8 GO:0043589 skin morphogenesis(GO:0043589)
0.0 4.8 GO:0009615 response to virus(GO:0009615)
0.9 4.6 GO:0001661 conditioned taste aversion(GO:0001661)
0.4 4.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 3.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 3.7 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.1 3.5 GO:0070542 response to fatty acid(GO:0070542)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.6 GO:0043198 dendritic shaft(GO:0043198)
0.3 17.1 GO:0005581 collagen trimer(GO:0005581)
0.2 8.9 GO:0032420 stereocilium(GO:0032420)
0.3 7.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 7.6 GO:0009925 basal plasma membrane(GO:0009925)
0.3 6.7 GO:0005605 basal lamina(GO:0005605)
0.5 6.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 5.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 4.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
1.6 4.8 GO:0005584 collagen type I trimer(GO:0005584)
0.1 4.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 4.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 4.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 4.2 GO:0044295 axonal growth cone(GO:0044295)
0.2 3.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 3.5 GO:0001650 fibrillar center(GO:0001650)
0.4 3.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 3.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 3.3 GO:0043209 myelin sheath(GO:0043209)
0.1 3.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.6 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 19.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 17.9 GO:0005198 structural molecule activity(GO:0005198)
0.8 9.0 GO:0016151 nickel cation binding(GO:0016151)
2.7 8.0 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
2.7 8.0 GO:0016015 morphogen activity(GO:0016015)
1.9 7.8 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.2 6.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.6 6.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.8 5.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 5.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 4.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 4.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.5 4.6 GO:0070905 serine binding(GO:0070905)
0.0 4.5 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.9 3.5 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.1 3.0 GO:0004707 MAP kinase activity(GO:0004707)
0.0 3.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.4 2.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.3 2.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 21.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 8.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 8.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 7.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 6.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 2.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 2.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 1.8 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 22.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 14.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 8.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 7.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 6.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.7 5.4 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 4.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.4 4.8 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 4.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.6 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 2.4 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 2.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.8 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis