Motif ID: Pou1f1

Z-value: 1.131


Transcription factors associated with Pou1f1:

Gene SymbolEntrez IDGene Name
Pou1f1 ENSMUSG00000004842.12 Pou1f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou1f1mm10_v2_chr16_+_65520503_65520548-0.009.7e-01Click!


Activity profile for motif Pou1f1.

activity profile for motif Pou1f1


Sorted Z-values histogram for motif Pou1f1

Sorted Z-values for motif Pou1f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou1f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 15.438 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_107511416 11.902 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr7_-_103853199 11.228 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr1_+_107511489 8.840 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr13_-_62607499 8.604 ENSMUST00000091563.4
 6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr1_+_110099295 7.259 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr5_-_53707532 6.644 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr7_-_14562171 6.526 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr7_-_28008416 6.338 ENSMUST00000180024.1
 Zfp850
zinc finger protein 850
chr2_+_164074122 5.620 ENSMUST00000018353.7
 Stk4
serine/threonine kinase 4
chr11_-_11970540 5.600 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr1_+_109993982 5.515 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr1_+_66364623 5.185 ENSMUST00000077355.5
ENSMUST00000114012.1
 Map2

microtubule-associated protein 2

chr17_+_21690766 5.153 ENSMUST00000097384.1
 Gm10509
predicted gene 10509
chr13_-_62371936 5.068 ENSMUST00000107989.3
 Gm3604
predicted gene 3604
chr8_+_69300776 4.877 ENSMUST00000078257.6
 D130040H23Rik
RIKEN cDNA D130040H23 gene
chr4_+_134510999 4.859 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr13_+_104229366 4.652 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr9_-_79977782 4.457 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr7_+_82611777 4.397 ENSMUST00000172784.1
 Adamtsl3
ADAMTS-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 266 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 26.8 GO:0006355 regulation of transcription, DNA-templated(GO:0006355)
0.2 15.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.6 13.0 GO:0015671 oxygen transport(GO:0015671)
0.1 12.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.2 8.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
2.2 6.6 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.7 6.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
2.1 6.2 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.3 5.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.4 5.6 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 5.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 5.3 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.1 4.9 GO:0021591 ventricular system development(GO:0021591)
0.6 4.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.4 4.6 GO:0000012 single strand break repair(GO:0000012)
1.5 4.4 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
1.0 4.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.4 4.1 GO:0006020 inositol metabolic process(GO:0006020)
0.8 3.9 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.4 3.8 GO:1902913 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of neuroepithelial cell differentiation(GO:1902913)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.5 GO:0016604 nuclear body(GO:0016604)
0.1 9.3 GO:0070469 respiratory chain(GO:0070469)
0.8 7.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
2.1 6.2 GO:0071914 prominosome(GO:0071914)
1.2 5.9 GO:0097149 centralspindlin complex(GO:0097149)
0.5 5.4 GO:0032009 early phagosome(GO:0032009)
0.1 5.2 GO:0000922 spindle pole(GO:0000922)
0.0 4.5 GO:0043195 terminal bouton(GO:0043195)
0.0 4.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 4.1 GO:0005871 kinesin complex(GO:0005871)
0.2 4.0 GO:0034451 centriolar satellite(GO:0034451)
0.4 3.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 3.7 GO:0005874 microtubule(GO:0005874)
0.4 3.6 GO:0097165 nuclear stress granule(GO:0097165)
0.0 3.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 3.2 GO:0000776 kinetochore(GO:0000776)
0.3 2.9 GO:0000796 condensin complex(GO:0000796)
0.2 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 2.8 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 2.8 GO:0005876 spindle microtubule(GO:0005876)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 46.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.3 14.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
2.6 13.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 8.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.9 7.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 5.8 GO:0045296 cadherin binding(GO:0045296)
0.1 5.5 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
1.8 5.4 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.0 5.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 4.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 4.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.1 4.4 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 4.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.3 3.9 GO:0042936 dipeptide transporter activity(GO:0042936)
0.2 3.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.6 3.7 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.9 3.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 3.6 GO:0003743 translation initiation factor activity(GO:0003743)
1.2 3.5 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.4 3.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 8.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 7.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 7.0 PID_LKB1_PATHWAY LKB1 signaling events
0.1 5.9 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 3.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.9 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.1 2.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.2 1.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 1.3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 1.3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.0 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 8.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 7.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 7.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 6.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.3 6.0 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.3 5.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 4.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 4.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 4.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 3.3 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 3.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 3.0 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 3.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 2.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 2.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition