Motif ID: Pou2f2_Pou3f1

Z-value: 1.741

Transcription factors associated with Pou2f2_Pou3f1:

Gene SymbolEntrez IDGene Name
Pou2f2 ENSMUSG00000008496.12 Pou2f2
Pou3f1 ENSMUSG00000090125.2 Pou3f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f1mm10_v2_chr4_+_124657646_124657656-0.551.7e-07Click!
Pou2f2mm10_v2_chr7_-_25132473_25132512-0.262.2e-02Click!


Activity profile for motif Pou2f2_Pou3f1.

activity profile for motif Pou2f2_Pou3f1


Sorted Z-values histogram for motif Pou2f2_Pou3f1

Sorted Z-values for motif Pou2f2_Pou3f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou2f2_Pou3f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_67234620 49.456 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr6_-_67037399 48.487 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr14_+_13454010 29.996 ENSMUST00000112656.2
 Synpr
synaptoporin
chr13_-_56252163 28.413 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr6_+_8949670 28.104 ENSMUST00000060369.3
 Nxph1
neurexophilin 1
chr2_+_103566304 26.038 ENSMUST00000076212.3
 Abtb2
ankyrin repeat and BTB (POZ) domain containing 2
chr7_+_45017953 24.696 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr14_+_13453937 23.918 ENSMUST00000153954.1
 Synpr
synaptoporin
chr1_+_6730051 20.327 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr19_+_20601958 20.290 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr12_+_38781093 19.235 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr7_-_102100227 18.892 ENSMUST00000106937.1
 Art5
ADP-ribosyltransferase 5
chr8_+_45627709 18.890 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr2_+_172549581 18.326 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr12_+_38780284 18.295 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr9_+_74848437 16.837 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
 Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr12_+_38780817 16.698 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr11_+_95337012 16.111 ENSMUST00000037502.6
 Fam117a
family with sequence similarity 117, member A
chr8_+_108714644 15.363 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr2_+_105675478 14.974 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 63.9 GO:0006342 chromatin silencing(GO:0006342)
4.7 61.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
4.9 54.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
2.9 49.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
3.9 47.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.2 34.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.3 29.7 GO:0006334 nucleosome assembly(GO:0006334)
1.7 29.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
5.8 29.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
7.1 28.4 GO:0021648 zygotic determination of anterior/posterior axis, embryo(GO:0007354) cranial nerve formation(GO:0021603) vestibulocochlear nerve morphogenesis(GO:0021648)
8.9 26.6 GO:0060853 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
1.3 26.0 GO:0097237 cellular response to toxic substance(GO:0097237)
2.2 25.8 GO:0002227 innate immune response in mucosa(GO:0002227)
0.5 24.7 GO:0060325 face morphogenesis(GO:0060325)
0.5 23.8 GO:0006284 base-excision repair(GO:0006284)
1.5 19.2 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
1.3 19.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
6.1 18.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 15.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
5.1 15.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 146.8 GO:0005634 nucleus(GO:0005634)
1.0 73.7 GO:0000786 nucleosome(GO:0000786)
0.2 63.1 GO:0000790 nuclear chromatin(GO:0000790)
2.2 53.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 52.0 GO:0016607 nuclear speck(GO:0016607)
0.4 46.7 GO:0032993 protein-DNA complex(GO:0032993)
7.4 29.5 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.4 26.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
3.4 23.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
4.2 20.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 19.2 GO:0016605 PML body(GO:0016605)
0.2 17.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 15.1 GO:0016324 apical plasma membrane(GO:0016324)
0.3 14.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 12.5 GO:0035102 PRC1 complex(GO:0035102)
0.0 11.7 GO:0005925 focal adhesion(GO:0005925)
0.8 10.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 10.0 GO:0043204 perikaryon(GO:0043204)
2.5 9.9 GO:0061702 inflammasome complex(GO:0061702)
0.4 9.9 GO:0070822 Sin3-type complex(GO:0070822)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 179.6 GO:0001047 core promoter binding(GO:0001047)
0.4 111.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
3.3 52.9 GO:0003680 AT DNA binding(GO:0003680)
0.8 37.0 GO:0070888 E-box binding(GO:0070888)
0.0 36.2 GO:0003677 DNA binding(GO:0003677)
0.1 33.4 GO:0046982 protein heterodimerization activity(GO:0046982)
10.7 32.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.4 24.7 GO:0019003 GDP binding(GO:0019003)
1.0 23.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.9 14.7 GO:0030957 Tat protein binding(GO:0030957)
2.3 13.9 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 13.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 12.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 12.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.9 12.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
2.4 11.9 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
1.3 11.8 GO:0030274 LIM domain binding(GO:0030274)
2.2 10.9 GO:0043515 kinetochore binding(GO:0043515)
1.4 9.9 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
1.3 8.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 69.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
2.0 61.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.8 44.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.3 28.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 25.7 PID_CDC42_PATHWAY CDC42 signaling events
0.4 25.5 PID_IL4_2PATHWAY IL4-mediated signaling events
0.4 24.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.5 21.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 19.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 12.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.4 11.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 11.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 9.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 4.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 4.0 PID_IL23_PATHWAY IL23-mediated signaling events
0.1 3.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 3.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 3.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 84.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
2.1 29.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.5 24.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
3.0 23.8 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 22.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
5.1 20.3 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.8 19.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 16.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 15.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 15.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
1.1 14.7 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 13.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.8 11.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 10.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.6 10.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 8.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.6 8.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 4.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 4.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 2.8 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes