Motif ID: Pou3f2

Z-value: 1.041


Transcription factors associated with Pou3f2:

Gene SymbolEntrez IDGene Name
Pou3f2 ENSMUSG00000095139.1 Pou3f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f2mm10_v2_chr4_-_22488296_224883660.316.4e-03Click!


Activity profile for motif Pou3f2.

activity profile for motif Pou3f2


Sorted Z-values histogram for motif Pou3f2

Sorted Z-values for motif Pou3f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f2

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_51621830 19.512 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr6_-_23248264 13.514 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr19_+_60144682 11.699 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr4_-_110286581 11.538 ENSMUST00000138972.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_-_47418407 11.197 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr18_+_5593566 11.156 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr11_+_23256566 9.959 ENSMUST00000136235.1
 Xpo1
exportin 1, CRM1 homolog (yeast)
chr3_-_36571952 9.917 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr2_-_60125651 9.339 ENSMUST00000112550.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr4_-_109665249 9.279 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr16_-_36784784 8.214 ENSMUST00000165531.1
 Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr16_-_36784924 7.474 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr2_-_62483637 6.976 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr10_-_69352886 6.960 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chrX_-_145505136 6.595 ENSMUST00000112835.1
 Amot
angiomotin
chr14_+_99046406 6.404 ENSMUST00000022656.6
 Bora
bora, aurora kinase A activator
chr3_+_88207308 6.296 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chrX_-_145505175 6.126 ENSMUST00000143610.1
 Amot
angiomotin
chr3_+_88206786 6.091 ENSMUST00000181134.1
ENSMUST00000181550.1
 Gm3764

predicted gene 3764

chr1_-_139377094 5.843 ENSMUST00000131586.1
ENSMUST00000145244.1
 Crb1

crumbs homolog 1 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 19.5 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
3.1 15.7 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
2.3 13.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.6 12.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
3.2 12.7 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 11.5 GO:0043488 regulation of mRNA stability(GO:0043488)
1.2 11.2 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 9.9 GO:0016572 histone phosphorylation(GO:0016572)
0.3 9.3 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
1.0 7.0 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.8 7.0 GO:0090166 Golgi disassembly(GO:0090166)
0.2 6.4 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.7 6.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.8 5.6 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
1.4 5.5 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.9 5.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.4 5.1 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.2 4.9 GO:0043486 histone exchange(GO:0043486)
1.4 4.2 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.3 4.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 19.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.2 12.9 GO:0005642 annulate lamellae(GO:0005642)
0.3 12.7 GO:0008180 COP9 signalosome(GO:0008180)
0.8 11.5 GO:0042788 polysomal ribosome(GO:0042788)
0.6 11.2 GO:0031616 spindle pole centrosome(GO:0031616)
1.4 9.9 GO:0001940 male pronucleus(GO:0001940)
0.1 7.8 GO:0005814 centriole(GO:0005814)
0.0 7.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 7.0 GO:0005876 spindle microtubule(GO:0005876)
0.7 6.4 GO:0072687 meiotic spindle(GO:0072687)
0.1 5.8 GO:0005902 microvillus(GO:0005902)
0.2 5.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.4 5.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 5.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 4.7 GO:0005801 cis-Golgi network(GO:0005801)
0.8 4.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 4.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 3.1 GO:0043034 costamere(GO:0043034)
0.2 2.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.6 GO:0097470 ribbon synapse(GO:0097470)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 19.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
5.2 15.7 GO:0042936 dipeptide transporter activity(GO:0042936)
0.1 13.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.3 12.9 GO:0005049 nuclear export signal receptor activity(GO:0005049)
2.5 12.7 GO:0043532 angiostatin binding(GO:0043532)
0.3 11.5 GO:0017091 AU-rich element binding(GO:0017091)
0.2 11.2 GO:0070888 E-box binding(GO:0070888)
0.2 9.9 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.7 9.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 7.3 GO:0005509 calcium ion binding(GO:0005509)
0.5 7.0 GO:0035173 histone kinase activity(GO:0035173)
0.0 6.4 GO:0004386 helicase activity(GO:0004386)
0.8 6.2 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 6.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.4 5.5 GO:0043495 protein anchor(GO:0043495)
0.5 5.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 4.9 GO:0042393 histone binding(GO:0042393)
0.8 4.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 4.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 4.2 GO:0032452 histone demethylase activity(GO:0032452)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 11.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.6 11.1 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.7 9.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 7.1 PID_E2F_PATHWAY E2F transcription factor network
0.8 7.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 7.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 6.4 PID_PLK1_PATHWAY PLK1 signaling events
0.1 5.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 2.9 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.7 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.1 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.7 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 30.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
1.8 29.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 12.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 9.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 7.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 4.2 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 3.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 3.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 2.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 2.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 0.9 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions