Motif ID: Pou3f2

Z-value: 1.041


Transcription factors associated with Pou3f2:

Gene SymbolEntrez IDGene Name
Pou3f2 ENSMUSG00000095139.1 Pou3f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f2mm10_v2_chr4_-_22488296_224883660.316.4e-03Click!


Activity profile for motif Pou3f2.

activity profile for motif Pou3f2


Sorted Z-values histogram for motif Pou3f2

Sorted Z-values for motif Pou3f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_51621830 19.512 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr6_-_23248264 13.514 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr19_+_60144682 11.699 ENSMUST00000065383.4
E330013P04Rik
RIKEN cDNA E330013P04 gene
chr4_-_110286581 11.538 ENSMUST00000138972.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_-_47418407 11.197 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr18_+_5593566 11.156 ENSMUST00000160910.1
Zeb1
zinc finger E-box binding homeobox 1
chr11_+_23256566 9.959 ENSMUST00000136235.1
Xpo1
exportin 1, CRM1 homolog (yeast)
chr3_-_36571952 9.917 ENSMUST00000029270.3
Ccna2
cyclin A2
chr2_-_60125651 9.339 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr4_-_109665249 9.279 ENSMUST00000063531.4
Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr16_-_36784784 8.214 ENSMUST00000165531.1
Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr16_-_36784924 7.474 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr2_-_62483637 6.976 ENSMUST00000136686.1
ENSMUST00000102733.3
Gcg

glucagon

chr10_-_69352886 6.960 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chrX_-_145505136 6.595 ENSMUST00000112835.1
Amot
angiomotin
chr14_+_99046406 6.404 ENSMUST00000022656.6
Bora
bora, aurora kinase A activator
chr3_+_88207308 6.296 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chrX_-_145505175 6.126 ENSMUST00000143610.1
Amot
angiomotin
chr3_+_88206786 6.091 ENSMUST00000181134.1
ENSMUST00000181550.1
Gm3764

predicted gene 3764

chr1_-_139377094 5.843 ENSMUST00000131586.1
ENSMUST00000145244.1
Crb1

crumbs homolog 1 (Drosophila)

chr19_+_38930909 5.616 ENSMUST00000025965.5
Hells
helicase, lymphoid specific
chr12_+_52699297 5.451 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr7_+_75610038 5.313 ENSMUST00000125771.1
Akap13
A kinase (PRKA) anchor protein 13
chr14_+_84443553 5.064 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chrX_-_162159717 4.885 ENSMUST00000087085.3
Nhs
Nance-Horan syndrome (human)
chr12_-_91384403 4.334 ENSMUST00000141429.1
Cep128
centrosomal protein 128
chr6_+_34384218 4.238 ENSMUST00000038383.7
ENSMUST00000115051.1
Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr1_+_150392794 4.225 ENSMUST00000124973.2
Tpr
translocated promoter region
chr13_+_44840686 4.193 ENSMUST00000173906.1
Jarid2
jumonji, AT rich interactive domain 2
chr9_-_105521147 3.776 ENSMUST00000176770.1
ENSMUST00000085133.6
Atp2c1

ATPase, Ca++-sequestering

chr2_+_61593077 3.776 ENSMUST00000112495.1
ENSMUST00000112501.2
Tank

TRAF family member-associated Nf-kappa B activator

chr3_-_157925056 3.696 ENSMUST00000118539.1
Cth
cystathionase (cystathionine gamma-lyase)
chr5_-_111761697 3.652 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr16_+_36875119 3.642 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr12_+_71170589 3.445 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr14_-_88471396 3.441 ENSMUST00000061628.5
Pcdh20
protocadherin 20
chr3_+_88965812 3.430 ENSMUST00000090933.4
Ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr1_+_74661714 3.376 ENSMUST00000042125.8
ENSMUST00000141119.1
Ttll4

tubulin tyrosine ligase-like family, member 4

chr18_+_4920509 3.124 ENSMUST00000126977.1
Svil
supervillin
chr15_+_36179530 3.097 ENSMUST00000171205.1
Spag1
sperm associated antigen 1
chr7_-_140822124 3.090 ENSMUST00000106052.1
ENSMUST00000080651.6
Zfp941

zinc finger protein 941

chr11_+_23256001 2.965 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
Xpo1



exportin 1, CRM1 homolog (yeast)



chr2_+_80315461 2.938 ENSMUST00000028392.7
Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr1_+_74661794 2.829 ENSMUST00000129890.1
Ttll4
tubulin tyrosine ligase-like family, member 4
chr8_-_41041828 2.764 ENSMUST00000051379.7
Mtus1
mitochondrial tumor suppressor 1
chr3_+_95929246 2.635 ENSMUST00000165307.1
ENSMUST00000015893.6
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr14_-_16575456 2.626 ENSMUST00000063750.6
Rarb
retinoic acid receptor, beta
chr7_-_133015248 2.616 ENSMUST00000169570.1
Ctbp2
C-terminal binding protein 2
chr10_+_57794335 2.545 ENSMUST00000151623.1
ENSMUST00000020022.7
Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

chr3_+_95929325 2.281 ENSMUST00000171368.1
ENSMUST00000168106.1
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr10_-_53630439 2.228 ENSMUST00000075540.5
Mcm9
minichromosome maintenance complex component 9
chr14_+_79515618 2.134 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr9_+_44981779 1.996 ENSMUST00000034602.7
Cd3d
CD3 antigen, delta polypeptide
chr9_+_88839164 1.983 ENSMUST00000163255.2
Trim43c
tripartite motif-containing 43C
chr8_+_85171322 1.960 ENSMUST00000076896.5
Gm6531
predicted gene 6531
chr1_-_150465563 1.938 ENSMUST00000164600.1
ENSMUST00000111902.2
ENSMUST00000111901.2
ENSMUST00000006171.9
Prg4



proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)



chr3_-_51560816 1.828 ENSMUST00000037141.7
Setd7
SET domain containing (lysine methyltransferase) 7
chr7_+_16781341 1.801 ENSMUST00000108496.2
Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr1_-_156036473 1.700 ENSMUST00000097527.3
ENSMUST00000027738.7
Tor1aip1

torsin A interacting protein 1

chr12_-_31351368 1.674 ENSMUST00000110857.3
Dld
dihydrolipoamide dehydrogenase
chr11_-_98625661 1.659 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr2_+_140152043 1.545 ENSMUST00000104994.2
Gm17374
predicted gene, 17374
chr9_+_88581036 1.427 ENSMUST00000164661.2
Trim43a
tripartite motif-containing 43A
chrX_+_164419782 1.409 ENSMUST00000033754.7
Piga
phosphatidylinositol glycan anchor biosynthesis, class A
chr8_-_41054771 1.328 ENSMUST00000093534.4
Mtus1
mitochondrial tumor suppressor 1
chr17_-_83514311 1.316 ENSMUST00000167741.1
ENSMUST00000025095.7
Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr5_+_86804508 1.256 ENSMUST00000038384.7
Ythdc1
YTH domain containing 1
chr9_-_89092835 1.219 ENSMUST00000167113.1
Trim43b
tripartite motif-containing 43B
chr1_-_52490736 1.209 ENSMUST00000170269.1
Nab1
Ngfi-A binding protein 1
chr2_-_136387929 1.196 ENSMUST00000035264.2
ENSMUST00000077200.3
Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chr1_-_150392719 1.189 ENSMUST00000006167.6
ENSMUST00000094477.2
ENSMUST00000097547.3
BC003331


cDNA sequence BC003331


chr14_+_73138755 1.124 ENSMUST00000171070.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr6_-_99632376 1.124 ENSMUST00000176255.1
Gm20696
predicted gene 20696
chr12_+_51377560 1.106 ENSMUST00000021335.5
Scfd1
Sec1 family domain containing 1
chrX_+_96456362 1.073 ENSMUST00000079322.5
ENSMUST00000113838.1
Heph

hephaestin

chr4_+_11758147 1.013 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr6_+_29694204 0.964 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chr2_+_104590453 0.942 ENSMUST00000028599.7
Cstf3
cleavage stimulation factor, 3' pre-RNA, subunit 3
chr17_-_24163668 0.939 ENSMUST00000040735.5
Amdhd2
amidohydrolase domain containing 2
chr3_+_66985680 0.914 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr5_+_14025305 0.898 ENSMUST00000073957.6
Sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr11_-_23519181 0.896 ENSMUST00000020527.5
1700093K21Rik
RIKEN cDNA 1700093K21 gene
chr18_-_43477764 0.747 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr6_-_134887783 0.743 ENSMUST00000066107.6
Gpr19
G protein-coupled receptor 19
chr7_+_119690026 0.611 ENSMUST00000047045.8
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr16_-_17561240 0.434 ENSMUST00000065125.5
ENSMUST00000100123.3
ENSMUST00000023442.6
4930451C15Rik


RIKEN cDNA 4930451C15 gene


chr5_+_107497762 0.391 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr17_-_6449571 0.354 ENSMUST00000180035.1
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr16_+_44867097 0.350 ENSMUST00000102805.3
Cd200r2
Cd200 receptor 2
chr3_+_66985700 0.244 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr5_+_107497718 0.224 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr19_+_47067721 0.212 ENSMUST00000026027.5
Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr3_+_103809520 0.187 ENSMUST00000076599.1
ENSMUST00000106824.1
ENSMUST00000106823.1
ENSMUST00000047285.2
Ap4b1



adaptor-related protein complex AP-4, beta 1



chr16_-_36874806 0.093 ENSMUST00000075946.5
Eaf2
ELL associated factor 2
chr5_-_24527276 0.067 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr6_+_8209216 0.061 ENSMUST00000040017.7
Mios
missing oocyte, meiosis regulator, homolog (Drosophila)
chr3_+_66985947 0.041 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr1_+_167618246 0.027 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr2_-_84650760 0.024 ENSMUST00000111691.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr19_+_44203265 0.005 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 12.7 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
3.1 15.7 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
2.3 13.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.2 19.5 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
1.6 12.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
1.4 4.2 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
1.4 5.5 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
1.2 11.2 GO:0048752 semicircular canal morphogenesis(GO:0048752)
1.2 3.7 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
1.0 7.0 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.9 3.8 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.9 3.8 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.9 5.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.8 5.6 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.8 7.0 GO:0090166 Golgi disassembly(GO:0090166)
0.7 6.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.6 1.7 GO:0009106 lipoate metabolic process(GO:0009106)
0.5 3.4 GO:0002674 negative regulation of acute inflammatory response(GO:0002674)
0.5 1.9 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.5 1.8 GO:0015825 L-serine transport(GO:0015825)
0.4 2.6 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.4 2.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.4 2.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.4 5.1 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.3 9.3 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.3 1.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.3 4.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 9.9 GO:0016572 histone phosphorylation(GO:0016572)
0.3 2.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 1.8 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.2 2.0 GO:0045059 positive thymic T cell selection(GO:0045059)
0.2 4.9 GO:0043486 histone exchange(GO:0043486)
0.2 6.4 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 1.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 2.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 4.1 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.2 0.9 GO:1901072 glucosamine-containing compound catabolic process(GO:1901072)
0.1 11.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 4.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 1.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 1.3 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.1 2.2 GO:0006270 DNA replication initiation(GO:0006270)
0.1 4.1 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 3.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.1 GO:0007338 single fertilization(GO:0007338)
0.0 1.2 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 1.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.9 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.9 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:0019230 proprioception(GO:0019230)
0.0 3.4 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 3.1 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.0 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 9.9 GO:0001940 male pronucleus(GO:0001940)
1.2 12.9 GO:0005642 annulate lamellae(GO:0005642)
0.8 4.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.8 19.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.8 11.5 GO:0042788 polysomal ribosome(GO:0042788)
0.7 6.4 GO:0072687 meiotic spindle(GO:0072687)
0.6 11.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 2.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.4 5.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 12.7 GO:0008180 COP9 signalosome(GO:0008180)
0.2 2.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 1.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.2 5.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 4.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.2 GO:0042555 MCM complex(GO:0042555)
0.1 2.6 GO:0097470 ribbon synapse(GO:0097470)
0.1 7.0 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 4.7 GO:0005801 cis-Golgi network(GO:0005801)
0.1 7.8 GO:0005814 centriole(GO:0005814)
0.1 5.8 GO:0005902 microvillus(GO:0005902)
0.1 3.1 GO:0043034 costamere(GO:0043034)
0.1 5.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.3 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 7.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.7 GO:0042936 dipeptide transporter activity(GO:0042936)
2.5 12.7 GO:0043532 angiostatin binding(GO:0043532)
1.3 12.9 GO:0005049 nuclear export signal receptor activity(GO:0005049)
1.0 19.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.9 3.8 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.9 3.8 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.8 4.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.8 6.2 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.7 9.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.6 3.4 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.5 5.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.5 1.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.5 7.0 GO:0035173 histone kinase activity(GO:0035173)
0.5 3.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.4 5.5 GO:0043495 protein anchor(GO:0043495)
0.3 1.7 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.3 2.6 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.3 2.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 11.5 GO:0017091 AU-rich element binding(GO:0017091)
0.2 11.2 GO:0070888 E-box binding(GO:0070888)
0.2 9.9 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.2 1.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.6 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.2 4.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.2 2.9 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 1.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 2.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 4.2 GO:0032452 histone demethylase activity(GO:0032452)
0.1 1.7 GO:0005521 lamin binding(GO:0005521)
0.1 13.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 6.4 GO:0004386 helicase activity(GO:0004386)
0.0 2.1 GO:0005179 hormone activity(GO:0005179)
0.0 6.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 4.9 GO:0042393 histone binding(GO:0042393)
0.0 0.9 GO:0019213 deacetylase activity(GO:0019213)
0.0 3.1 GO:0051015 actin filament binding(GO:0051015)
0.0 1.1 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 7.3 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.7 9.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6 11.1 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 11.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 11.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 7.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.4 PID_PLK1_PATHWAY PLK1 signaling events
0.1 7.1 PID_E2F_PATHWAY E2F transcription factor network
0.1 5.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 2.7 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.1 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.9 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.7 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 29.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.5 30.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.4 7.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.4 12.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.3 2.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 9.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 3.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 3.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 4.2 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 1.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 3.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 0.9 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport