Motif ID: Pou3f4

Z-value: 0.930


Transcription factors associated with Pou3f4:

Gene SymbolEntrez IDGene Name
Pou3f4 ENSMUSG00000056854.3 Pou3f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f4mm10_v2_chrX_+_110814390_110814413-0.352.1e-03Click!


Activity profile for motif Pou3f4.

activity profile for motif Pou3f4


Sorted Z-values histogram for motif Pou3f4

Sorted Z-values for motif Pou3f4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22439719 16.221 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_22439570 16.027 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr1_+_159737510 13.417 ENSMUST00000111669.3
 Tnr
tenascin R
chr15_-_79285502 12.417 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr6_+_17463749 9.233 ENSMUST00000115443.1
 Met
met proto-oncogene
chr3_+_68869563 9.232 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr15_+_92161343 9.101 ENSMUST00000068378.5
 Cntn1
contactin 1
chr7_+_87803815 9.017 ENSMUST00000125009.1
ENSMUST00000155358.1
 Grm5

glutamate receptor, metabotropic 5

chr13_-_92030897 8.800 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr6_-_36811361 8.027 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr3_+_67892189 7.909 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr2_-_120245157 7.348 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr6_+_17463826 7.336 ENSMUST00000140070.1
 Met
met proto-oncogene
chr18_-_74961252 7.333 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr3_+_26331150 7.046 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr13_+_29016267 6.822 ENSMUST00000140415.1
 A330102I10Rik
RIKEN cDNA A330102I10 gene
chr10_+_90576252 6.267 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
 Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr11_+_93098404 5.998 ENSMUST00000107859.1
ENSMUST00000042943.6
ENSMUST00000107861.1
ENSMUST00000107858.2
 Car10



carbonic anhydrase 10



chr8_-_84773381 5.694 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_-_5676046 5.418 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 32.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.4 16.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
3.4 13.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.8 12.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 9.1 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
3.0 9.0 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.3 8.8 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
2.7 8.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
1.8 7.3 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 7.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.4 6.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 6.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.4 5.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.8 5.4 GO:0060267 positive regulation of respiratory burst(GO:0060267)
1.3 5.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.2 5.2 GO:0045475 locomotor rhythm(GO:0045475)
0.3 5.1 GO:0001553 luteinization(GO:0001553)
0.0 5.1 GO:0007416 synapse assembly(GO:0007416)
0.3 4.3 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 4.2 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.0 GO:0009925 basal plasma membrane(GO:0009925)
4.5 13.4 GO:0072534 perineuronal net(GO:0072534)
1.2 12.4 GO:0071439 clathrin complex(GO:0071439)
0.0 12.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 11.6 GO:0031225 anchored component of membrane(GO:0031225)
0.7 10.0 GO:0097449 astrocyte projection(GO:0097449)
0.1 8.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 7.4 GO:0005769 early endosome(GO:0005769)
0.0 7.3 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.5 5.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 5.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.7 4.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 3.7 GO:0043034 costamere(GO:0043034)
0.1 3.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.2 GO:0032993 protein-DNA complex(GO:0032993)
0.1 3.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.5 2.7 GO:0005955 calcineurin complex(GO:0005955)
0.6 2.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 2.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 16.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.8 13.4 GO:0046625 sphingolipid binding(GO:0046625)
2.3 9.0 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
2.7 8.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.8 7.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.4 7.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 6.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 5.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 5.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 5.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.7 5.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
1.0 5.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 5.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 5.1 GO:0005543 phospholipid binding(GO:0005543)
0.6 4.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 4.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.4 4.1 GO:0071723 lipopeptide binding(GO:0071723)
0.0 3.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.4 3.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 3.7 GO:0097602 cullin family protein binding(GO:0097602)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 29.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 16.6 PID_ARF6_PATHWAY Arf6 signaling events
0.1 16.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 9.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.4 8.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.4 8.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 4.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 3.1 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 2.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 2.5 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 9.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 8.8 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 5.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.4 4.1 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 3.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.1 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.2 3.0 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 2.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 2.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S