Motif ID: Pou4f1_Pou6f1

Z-value: 0.757

Transcription factors associated with Pou4f1_Pou6f1:

Gene SymbolEntrez IDGene Name
Pou4f1 ENSMUSG00000048349.8 Pou4f1
Pou6f1 ENSMUSG00000009739.10 Pou6f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou4f1mm10_v2_chr14_-_104467984_104468041-0.453.7e-05Click!
Pou6f1mm10_v2_chr15_-_100599983_1006000390.342.1e-03Click!


Activity profile for motif Pou4f1_Pou6f1.

activity profile for motif Pou4f1_Pou6f1


Sorted Z-values histogram for motif Pou4f1_Pou6f1

Sorted Z-values for motif Pou4f1_Pou6f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou4f1_Pou6f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22439719 9.632 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_22439570 8.530 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr15_+_92161343 7.540 ENSMUST00000068378.5
 Cntn1
contactin 1
chr10_-_64090241 6.967 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_+_42681513 6.177 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr14_-_30353468 5.038 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr6_-_36811361 5.015 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr1_-_56978534 4.482 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr11_-_42182924 4.397 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr11_+_98348404 4.241 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr2_-_120245157 3.944 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr8_+_68880491 3.623 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr4_+_102254993 3.523 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr13_+_83504032 3.512 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr4_+_102254739 3.265 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_+_68104671 3.182 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr18_-_74961252 3.170 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr2_+_97467657 3.151 ENSMUST00000059049.7
 Lrrc4c
leucine rich repeat containing 4C
chr3_+_26331150 3.087 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr10_-_64090265 3.018 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 18.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.9 11.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.7 10.0 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 7.5 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.1 5.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.3 5.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
1.7 5.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
1.3 5.0 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.6 4.5 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 4.5 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.5 4.4 GO:0071420 cellular response to histamine(GO:0071420)
0.3 4.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.4 4.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 3.9 GO:0009395 phospholipid catabolic process(GO:0009395)
0.2 3.7 GO:0016082 synaptic vesicle priming(GO:0016082)
0.9 3.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
1.2 3.5 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 3.5 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.8 3.2 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.7 2.9 GO:1901475 pyruvate transmembrane transport(GO:1901475)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 9.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 8.9 GO:0031225 anchored component of membrane(GO:0031225)
0.5 5.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 5.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 4.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 4.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 4.3 GO:0030017 sarcomere(GO:0030017)
0.0 4.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.4 4.0 GO:0071439 clathrin complex(GO:0071439)
0.5 3.6 GO:0042627 chylomicron(GO:0042627)
0.1 3.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 3.4 GO:0042641 actomyosin(GO:0042641)
0.0 3.2 GO:0005769 early endosome(GO:0005769)
0.3 2.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 2.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.7 2.7 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 2.6 GO:0030315 T-tubule(GO:0030315)
0.0 2.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 2.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 10.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 6.6 GO:0030246 carbohydrate binding(GO:0030246)
0.2 6.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.7 5.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.6 5.0 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.3 4.5 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.7 4.4 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.4 4.2 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.2 3.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.2 3.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 3.7 GO:0017124 SH3 domain binding(GO:0017124)
0.3 3.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 3.5 GO:0003680 AT DNA binding(GO:0003680)
0.2 3.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 3.5 GO:0000287 magnesium ion binding(GO:0000287)
0.8 3.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.8 3.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.7 2.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 2.9 GO:0035612 AP-2 adaptor complex binding(GO:0035612)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 18.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 7.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 5.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 4.5 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 4.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 3.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.0 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 0.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.7 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 7.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 4.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 3.6 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 3.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 2.9 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.6 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.7 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.5 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 1.2 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 1.2 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 1.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 0.9 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.9 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins