Motif ID: Pou5f1

Z-value: 0.976


Transcription factors associated with Pou5f1:

Gene SymbolEntrez IDGene Name
Pou5f1 ENSMUSG00000024406.10 Pou5f1



Activity profile for motif Pou5f1.

activity profile for motif Pou5f1


Sorted Z-values histogram for motif Pou5f1

Sorted Z-values for motif Pou5f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou5f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 19.160 ENSMUST00000164163.1
 Sla
src-like adaptor
chr8_-_84773381 17.391 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr10_+_85386813 14.341 ENSMUST00000105307.1
ENSMUST00000020231.3
 Btbd11

BTB (POZ) domain containing 11

chr8_+_118283719 13.793 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr6_-_138421379 12.633 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr5_+_129584169 10.698 ENSMUST00000031390.8
 Mmp17
matrix metallopeptidase 17
chr8_+_54954728 10.266 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr8_+_68880491 9.796 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr5_+_66968559 9.793 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr14_-_102982630 9.615 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr7_+_87803815 9.308 ENSMUST00000125009.1
ENSMUST00000155358.1
 Grm5

glutamate receptor, metabotropic 5

chr5_+_66968416 9.124 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr11_+_110399115 8.820 ENSMUST00000020949.5
ENSMUST00000100260.1
 Map2k6

mitogen-activated protein kinase kinase 6

chr14_-_39472825 8.722 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr1_-_168431695 8.576 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr5_+_66968961 8.467 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chrX_-_103483205 8.356 ENSMUST00000127786.2
 Xist
inactive X specific transcripts
chr7_+_91090697 8.104 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 7.980 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr10_-_64090265 7.966 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 32.4 GO:0031032 actomyosin structure organization(GO:0031032)
0.8 24.6 GO:0030325 adrenal gland development(GO:0030325)
4.7 23.6 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.3 18.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.1 16.1 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.0 15.0 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.4 14.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 14.3 GO:0060395 SMAD protein signal transduction(GO:0060395)
4.6 13.8 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.2 12.9 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.3 12.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.7 11.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.4 9.7 GO:0042756 drinking behavior(GO:0042756)
3.1 9.3 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
1.3 9.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.1 8.8 GO:0032308 positive regulation of prostaglandin secretion(GO:0032308)
2.9 8.7 GO:0060596 mammary placode formation(GO:0060596)
1.2 8.7 GO:0019532 oxalate transport(GO:0019532)
0.7 8.6 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
2.8 8.4 GO:0060708 spongiotrophoblast differentiation(GO:0060708)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 21.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 20.9 GO:0045211 postsynaptic membrane(GO:0045211)
1.2 19.8 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 19.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8 16.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.9 13.6 GO:0043196 varicosity(GO:0043196)
0.2 11.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 11.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 9.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.4 9.8 GO:0042627 chylomicron(GO:0042627)
0.1 9.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.4 8.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.8 8.4 GO:0000805 X chromosome(GO:0000805)
0.0 7.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.3 7.7 GO:0044308 axonal spine(GO:0044308)
0.1 7.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 7.5 GO:0005769 early endosome(GO:0005769)
2.0 6.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 5.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 5.6 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.4 GO:0003779 actin binding(GO:0003779)
2.8 22.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.5 19.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 16.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 16.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.7 16.1 GO:0004385 guanylate kinase activity(GO:0004385)
4.6 13.8 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
2.8 13.8 GO:0055100 adiponectin binding(GO:0055100)
1.1 12.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.8 12.4 GO:0045499 chemorepellent activity(GO:0045499)
0.1 10.3 GO:0005262 calcium channel activity(GO:0005262)
0.8 9.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 8.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.8 8.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 8.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 8.3 GO:0030552 cAMP binding(GO:0030552)
0.1 8.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 6.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 6.8 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 6.5 GO:0036002 pre-mRNA binding(GO:0036002)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 21.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.2 19.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 16.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 13.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 11.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 10.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.3 10.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4 8.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.6 8.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 8.6 PID_ATR_PATHWAY ATR signaling pathway
0.1 6.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 5.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 5.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 4.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 4.8 PID_SHP2_PATHWAY SHP2 signaling
0.2 4.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 4.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.5 PID_ALK1_PATHWAY ALK1 signaling events
0.1 4.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.7 18.2 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.7 10.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.7 9.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 9.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 9.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 8.8 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.1 8.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 7.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 6.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 6.0 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.3 5.6 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 5.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 4.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 4.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.1 4.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 4.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 3.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 3.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC