Motif ID: Pou6f2_Pou4f2
Z-value: 0.886
Transcription factors associated with Pou6f2_Pou4f2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pou4f2 | ENSMUSG00000031688.3 | Pou4f2 |
| Pou6f2 | ENSMUSG00000009734.11 | Pou6f2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou6f2 | mm10_v2_chr13_-_18382041_18382041 | -0.27 | 1.8e-02 | Click! |
| Pou4f2 | mm10_v2_chr8_-_78436640_78436649 | 0.13 | 2.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 23.0 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
| 4.7 | 14.0 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 4.2 | 58.1 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 2.6 | 18.3 | GO:0019532 | oxalate transport(GO:0019532) |
| 1.8 | 12.8 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.9 | 2.6 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.8 | 6.6 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.8 | 3.1 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.6 | 4.0 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.4 | 5.4 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.4 | 1.2 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
| 0.4 | 1.1 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.4 | 2.6 | GO:0098909 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.4 | 3.2 | GO:0031424 | keratinization(GO:0031424) |
| 0.4 | 1.1 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.3 | 1.0 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.3 | 3.0 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.3 | 6.2 | GO:0001553 | luteinization(GO:0001553) |
| 0.3 | 7.0 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.3 | 0.8 | GO:0060060 | post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
| 0.2 | 1.4 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 3.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.2 | 12.7 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.2 | 0.6 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.1 | 0.6 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.1 | 1.3 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 1.1 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.1 | 0.6 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 0.5 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 1.4 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) excitatory synapse assembly(GO:1904861) |
| 0.1 | 0.3 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.1 | 1.3 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.1 | 1.8 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.1 | 0.2 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.0 | 1.5 | GO:0000154 | rRNA modification(GO:0000154) |
| 0.0 | 0.7 | GO:0014823 | response to activity(GO:0014823) |
| 0.0 | 0.4 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 0.3 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 0.7 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.0 | 0.7 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 1.0 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 0.5 | GO:0000186 | activation of MAPKK activity(GO:0000186) positive regulation of TOR signaling(GO:0032008) |
| 0.0 | 1.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.2 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
| 0.0 | 0.1 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.1 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 58.1 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.8 | 12.8 | GO:0043196 | varicosity(GO:0043196) |
| 0.2 | 0.6 | GO:0044302 | dentate gyrus mossy fiber(GO:0044302) |
| 0.2 | 0.6 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.2 | 4.0 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 3.0 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 1.3 | GO:0005883 | neurofilament(GO:0005883) |
| 0.1 | 7.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 1.1 | GO:0090543 | Flemming body(GO:0090543) |
| 0.1 | 0.5 | GO:0098888 | extrinsic component of presynaptic membrane(GO:0098888) |
| 0.1 | 0.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.5 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.1 | 0.4 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 2.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 2.6 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 3.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 12.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 3.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 1.4 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.0 | 3.7 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 6.7 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.2 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.0 | 0.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 21.9 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 1.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 18.3 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 1.4 | 61.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 1.3 | 4.0 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 1.0 | 3.0 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 1.0 | 12.8 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.9 | 14.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.7 | 23.0 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.4 | 1.5 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.2 | 1.1 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
| 0.2 | 0.7 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.2 | 5.4 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 1.1 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 0.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 1.0 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.1 | 8.7 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 0.7 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.1 | 1.4 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.1 | 0.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 0.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 2.6 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.6 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.1 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.0 | 1.3 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 3.1 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 0.1 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 2.1 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 2.7 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.0 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 26.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.5 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.0 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.1 | 5.4 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.9 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 3.1 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.0 | 4.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.2 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.1 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.5 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 14.0 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.6 | 12.8 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.6 | 1.1 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.4 | 61.0 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 20.6 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 5.4 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 1.1 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 0.8 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 4.0 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 0.7 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 1.1 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 1.6 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 3.2 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.8 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.5 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
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