Motif ID: Ppara

Z-value: 1.825


Transcription factors associated with Ppara:

Gene SymbolEntrez IDGene Name
Ppara ENSMUSG00000022383.7 Ppara



Activity profile for motif Ppara.

activity profile for motif Ppara


Sorted Z-values histogram for motif Ppara

Sorted Z-values for motif Ppara



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppara

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 32.694 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr15_-_66801577 22.215 ENSMUST00000168589.1
 Sla
src-like adaptor
chr15_-_45114926 21.467 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chr6_-_138422898 21.294 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3


chrX_-_72656135 19.400 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr12_+_109545390 18.708 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr11_+_67586520 17.607 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_67586675 17.084 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr5_-_44799643 17.020 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr8_+_118283719 15.496 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr7_-_74554474 15.389 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr11_+_42419729 15.022 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr3_-_36690118 14.891 ENSMUST00000029271.4
 Trpc3
transient receptor potential cation channel, subfamily C, member 3
chr11_+_7063423 13.777 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr10_-_64090265 13.578 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr4_+_13751297 13.158 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_67221221 13.111 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr1_-_162478004 13.047 ENSMUST00000086074.5
ENSMUST00000070330.7
 Dnm3

dynamin 3

chr14_-_23803304 12.671 ENSMUST00000179836.1
ENSMUST00000172099.2
ENSMUST00000065788.8
ENSMUST00000179097.1
ENSMUST00000177634.1
ENSMUST00000074983.6
ENSMUST00000163322.2
ENSMUST00000100831.4
 Kcnma1







potassium large conductance calcium-activated channel, subfamily M, alpha member 1







chr11_-_33147400 12.527 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 330 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 36.8 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.1 32.1 GO:0051260 protein homooligomerization(GO:0051260)
3.5 31.3 GO:0071420 cellular response to histamine(GO:0071420)
1.0 28.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.6 26.5 GO:0006376 mRNA splice site selection(GO:0006376)
1.9 24.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
1.6 23.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
1.1 22.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
2.1 21.2 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
1.1 21.2 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
2.2 19.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
6.4 19.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.7 19.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
4.4 17.6 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
3.4 17.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.3 16.4 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.9 16.3 GO:0010669 epithelial structure maintenance(GO:0010669)
0.2 16.1 GO:0050807 regulation of synapse organization(GO:0050807)
5.2 15.5 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
3.1 15.5 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 50.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 45.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 37.6 GO:0009986 cell surface(GO:0009986)
0.2 35.0 GO:0005884 actin filament(GO:0005884)
0.2 30.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 27.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 27.3 GO:0043025 neuronal cell body(GO:0043025)
3.5 17.6 GO:0044316 cone cell pedicle(GO:0044316)
1.6 17.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.9 16.5 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.2 16.4 GO:0016363 nuclear matrix(GO:0016363)
0.2 15.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9 15.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
1.7 15.0 GO:0097427 microtubule bundle(GO:0097427)
0.6 15.0 GO:0030137 COPI-coated vesicle(GO:0030137)
0.3 13.6 GO:0009925 basal plasma membrane(GO:0009925)
1.3 13.1 GO:0044326 dendritic spine neck(GO:0044326)
0.7 13.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
4.3 13.0 GO:0072534 perineuronal net(GO:0072534)
3.3 13.0 GO:0098843 postsynaptic endocytic zone(GO:0098843)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 238 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 46.5 GO:0003779 actin binding(GO:0003779)
2.1 35.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.8 32.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 29.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 27.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.3 27.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
3.6 25.5 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.5 21.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
5.2 20.9 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.4 19.9 GO:0015459 potassium channel regulator activity(GO:0015459)
3.2 19.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
2.7 16.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
3.1 15.5 GO:0055100 adiponectin binding(GO:0055100)
1.4 15.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.5 15.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.0 15.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 15.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.1 14.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.3 14.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.4 13.6 GO:0030552 cAMP binding(GO:0030552)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 18.6 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 12.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 12.5 PID_FGF_PATHWAY FGF signaling pathway
0.7 11.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.7 9.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.3 9.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 8.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.4 6.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.3 6.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 6.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 5.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.4 5.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 5.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 5.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 5.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 5.5 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 4.8 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.2 4.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 4.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 50.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
1.2 38.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
3.2 25.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.6 24.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.6 22.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.8 22.1 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.6 21.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
2.4 19.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
1.4 14.9 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 14.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.0 11.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
1.4 11.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.5 11.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.4 11.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.8 10.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 10.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 9.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 9.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.4 8.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 8.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors