Motif ID: Ppard

Z-value: 0.776


Transcription factors associated with Ppard:

Gene SymbolEntrez IDGene Name
Ppard ENSMUSG00000002250.9 Ppard

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ppardmm10_v2_chr17_+_28232723_282327890.672.2e-11Click!


Activity profile for motif Ppard.

activity profile for motif Ppard


Sorted Z-values histogram for motif Ppard

Sorted Z-values for motif Ppard



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppard

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_87948666 17.633 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr5_-_115119277 11.892 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr15_+_25773985 10.496 ENSMUST00000125667.1
 Myo10
myosin X
chr4_+_59581563 9.187 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr4_+_59581645 8.905 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chrX_-_142306170 7.208 ENSMUST00000134825.2
 Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr4_+_118429701 4.841 ENSMUST00000067896.3
 Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr4_-_155043143 4.742 ENSMUST00000135665.2
 Plch2
phospholipase C, eta 2
chr11_+_70657687 4.709 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr2_+_154436437 4.702 ENSMUST00000109725.1
ENSMUST00000099178.3
ENSMUST00000045270.8
ENSMUST00000109724.1
 Cbfa2t2



core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)



chr1_-_120120138 4.668 ENSMUST00000112648.1
ENSMUST00000128408.1
 Dbi

diazepam binding inhibitor

chr4_+_131873608 4.594 ENSMUST00000053819.3
 Srsf4
serine/arginine-rich splicing factor 4
chr15_-_89425856 4.185 ENSMUST00000109313.2
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr9_+_118506226 4.098 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr3_-_79628660 4.066 ENSMUST00000120992.1
 Etfdh
electron transferring flavoprotein, dehydrogenase
chr9_-_51278540 3.976 ENSMUST00000114427.3
 Gm684
predicted gene 684
chr11_-_70015346 3.953 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr4_+_98546919 3.655 ENSMUST00000030290.7
 Inadl
InaD-like (Drosophila)
chr9_-_57262591 3.534 ENSMUST00000034846.5
 1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr10_-_13324160 3.401 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr4_+_98546710 3.187 ENSMUST00000102792.3
 Inadl
InaD-like (Drosophila)
chr10_+_128303322 2.861 ENSMUST00000005825.6
 Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr5_-_131538687 2.773 ENSMUST00000161374.1
 Auts2
autism susceptibility candidate 2
chr5_+_110286306 2.529 ENSMUST00000007296.5
ENSMUST00000112482.1
 Pole

polymerase (DNA directed), epsilon

chr19_+_37207528 2.521 ENSMUST00000024078.7
ENSMUST00000112391.1
 March5

membrane-associated ring finger (C3HC4) 5

chr2_+_75832168 2.504 ENSMUST00000047232.7
ENSMUST00000111952.2
 Agps

alkylglycerone phosphate synthase

chr9_+_46012810 2.463 ENSMUST00000126865.1
 Sik3
SIK family kinase 3
chr2_-_26237368 2.444 ENSMUST00000036187.8
 Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr15_-_89425795 2.274 ENSMUST00000168376.1
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr10_+_94147982 2.178 ENSMUST00000105290.2
 Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr15_-_102189032 2.146 ENSMUST00000023805.1
 Csad
cysteine sulfinic acid decarboxylase
chr3_-_138131356 2.031 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr19_-_32061438 2.008 ENSMUST00000096119.4
 Asah2
N-acylsphingosine amidohydrolase 2
chr3_-_79628859 1.934 ENSMUST00000029386.7
 Etfdh
electron transferring flavoprotein, dehydrogenase
chr19_-_6921753 1.902 ENSMUST00000173635.1
 Esrra
estrogen related receptor, alpha
chr7_+_141468776 1.771 ENSMUST00000058746.5
 Cd151
CD151 antigen
chr8_-_111393810 1.740 ENSMUST00000038475.8
 Fa2h
fatty acid 2-hydroxylase
chr19_+_4594312 1.623 ENSMUST00000113825.2
 Pcx
pyruvate carboxylase
chr9_+_46012822 1.551 ENSMUST00000120463.2
ENSMUST00000120247.1
 Sik3

SIK family kinase 3

chr7_+_43444104 1.422 ENSMUST00000004729.3
 Etfb
electron transferring flavoprotein, beta polypeptide
chr17_-_34028044 1.415 ENSMUST00000045467.7
ENSMUST00000114303.3
 H2-Ke6

H2-K region expressed gene 6

chr17_+_52602700 1.397 ENSMUST00000039366.10
 Kcnh8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr9_+_107340593 1.268 ENSMUST00000042581.2
 6430571L13Rik
RIKEN cDNA 6430571L13 gene
chr4_+_118409331 1.265 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr15_-_50890396 1.263 ENSMUST00000185183.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr16_+_84834901 1.200 ENSMUST00000114184.1
 Gabpa
GA repeat binding protein, alpha
chr4_-_118409219 1.019 ENSMUST00000075406.5
 Szt2
seizure threshold 2
chr4_-_41048124 0.993 ENSMUST00000030136.6
 Aqp7
aquaporin 7
chr19_-_6921804 0.968 ENSMUST00000025906.4
 Esrra
estrogen related receptor, alpha
chr7_+_82648595 0.885 ENSMUST00000141726.1
ENSMUST00000179489.1
ENSMUST00000039881.3
 Eftud1


elongation factor Tu GTP binding domain containing 1


chr2_-_73911323 0.884 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr16_+_84835070 0.835 ENSMUST00000009120.7
 Gabpa
GA repeat binding protein, alpha
chr8_+_117095854 0.796 ENSMUST00000034308.8
ENSMUST00000167370.1
ENSMUST00000176860.1
 Bcmo1


beta-carotene 15,15'-monooxygenase


chr6_+_7844806 0.795 ENSMUST00000040159.4
 C1galt1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr5_-_31697598 0.778 ENSMUST00000031018.7
 Rbks
ribokinase
chr19_+_46152505 0.664 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr4_-_137048695 0.505 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40
chr5_+_31697665 0.428 ENSMUST00000080598.7
 Bre
brain and reproductive organ-expressed protein
chr6_-_97459279 0.409 ENSMUST00000113359.1
 Frmd4b
FERM domain containing 4B
chr5_+_129725063 0.398 ENSMUST00000086046.3
 Gbas
glioblastoma amplified sequence
chr16_-_84835557 0.397 ENSMUST00000138279.1
ENSMUST00000023608.7
 Atp5j

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F

chr9_+_108662098 0.331 ENSMUST00000035222.5
 Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr3_+_90051630 0.316 ENSMUST00000159064.1
 4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr10_-_93589621 0.263 ENSMUST00000020203.6
 Snrpf
small nuclear ribonucleoprotein polypeptide F
chr9_-_107872687 0.213 ENSMUST00000035201.6
 Rbm6
RNA binding motif protein 6
chr9_-_107872821 0.206 ENSMUST00000183032.1
 Rbm6
RNA binding motif protein 6
chr3_-_8923796 0.137 ENSMUST00000042148.5
 Mrps28
mitochondrial ribosomal protein S28
chr1_+_178319130 0.065 ENSMUST00000027781.6
 Cox20
COX20 Cox2 chaperone
chr9_-_107872403 0.002 ENSMUST00000183035.1
 Rbm6
RNA binding motif protein 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 17.6 GO:0042573 retinoic acid metabolic process(GO:0042573)
1.3 11.9 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
1.0 7.2 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.9 4.7 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.9 2.8 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.8 2.5 GO:0045004 DNA replication proofreading(GO:0045004)
0.7 11.4 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.5 1.6 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.5 5.5 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.4 4.8 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.4 2.0 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.4 2.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 1.0 GO:0015793 glycerol transport(GO:0015793)
0.2 2.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 1.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 0.7 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 1.0 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.2 2.0 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.2 1.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 0.8 GO:0006014 D-ribose metabolic process(GO:0006014)
0.2 1.7 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.2 2.9 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.1 2.5 GO:0090344 negative regulation of cell aging(GO:0090344)
0.1 10.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 4.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 6.5 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.1 4.0 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.1 2.9 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1 4.1 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 1.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 4.7 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 0.3 GO:0015879 carnitine transport(GO:0015879)
0.0 1.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 2.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 4.7 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 14.3 GO:0055114 oxidation-reduction process(GO:0055114)
0.0 2.0 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.0 1.8 GO:0042098 T cell proliferation(GO:0042098)
0.0 0.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.4 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
1.0 2.9 GO:0031251 PAN complex(GO:0031251)
0.5 4.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 2.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.0 GO:1990130 Iml1 complex(GO:1990130)
0.2 4.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 10.5 GO:0016459 myosin complex(GO:0016459)
0.1 2.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 4.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 13.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 8.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 0.3 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 4.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.3 GO:0016592 mediator complex(GO:0016592)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.0 1.0 GO:0031526 brush border membrane(GO:0031526)
0.0 2.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 18.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 3.6 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 17.6 GO:0019841 retinol binding(GO:0019841)
1.6 4.7 GO:0030156 benzodiazepine receptor binding(GO:0030156)
1.5 6.0 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
1.3 4.0 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
1.3 6.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.9 7.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.8 2.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.8 11.9 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.6 2.4 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.5 4.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 4.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4 1.4 GO:0009055 electron carrier activity(GO:0009055)
0.3 1.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.3 2.0 GO:0017040 ceramidase activity(GO:0017040)
0.3 4.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 1.4 GO:0070404 NADH binding(GO:0070404)
0.3 1.6 GO:0009374 biotin binding(GO:0009374)
0.2 4.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 1.0 GO:0015254 glycerol channel activity(GO:0015254)
0.2 10.5 GO:0030507 spectrin binding(GO:0030507)
0.2 2.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.3 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.8 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 5.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 0.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 2.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.5 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 2.0 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 17.5 GO:0016491 oxidoreductase activity(GO:0016491)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 2.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 4.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.3 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 4.0 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.8 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 10.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 15.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 6.8 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 6.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 4.8 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 10.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 2.5 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 4.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 4.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 6.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 2.1 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.0 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.7 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.8 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 2.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.8 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.0 0.3 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.0 0.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins