Motif ID: Pparg_Rxrg

Z-value: 1.842

Transcription factors associated with Pparg_Rxrg:

Gene SymbolEntrez IDGene Name
Pparg ENSMUSG00000000440.6 Pparg
Rxrg ENSMUSG00000015843.4 Rxrg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrgmm10_v2_chr1_+_167598384_1675984110.152.0e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pparg_Rxrg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_77894096 39.377 ENSMUST00000017597.4
Pipox
pipecolic acid oxidase
chr5_-_115119277 30.476 ENSMUST00000031524.7
Acads
acyl-Coenzyme A dehydrogenase, short chain
chr17_+_35049966 29.377 ENSMUST00000007257.9
Clic1
chloride intracellular channel 1
chr11_+_80300866 25.662 ENSMUST00000017836.7
Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr4_+_126556935 19.833 ENSMUST00000048391.8
Clspn
claspin
chr13_-_24761861 19.501 ENSMUST00000006898.3
ENSMUST00000110382.2
Gmnn

geminin

chr11_+_61485431 19.371 ENSMUST00000064783.3
ENSMUST00000040522.6
Mfap4

microfibrillar-associated protein 4

chr4_-_126736236 19.226 ENSMUST00000048194.7
Tfap2e
transcription factor AP-2, epsilon
chr9_+_118506226 19.078 ENSMUST00000084820.4
Golga4
golgi autoantigen, golgin subfamily a, 4
chr2_-_79456750 18.484 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr3_+_87948666 17.782 ENSMUST00000005019.5
Crabp2
cellular retinoic acid binding protein II
chr1_-_138847579 16.683 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr14_+_54476100 16.597 ENSMUST00000164766.1
ENSMUST00000164697.1
Rem2

rad and gem related GTP binding protein 2

chr4_+_126556994 15.738 ENSMUST00000147675.1
Clspn
claspin
chr11_-_100354040 15.571 ENSMUST00000173630.1
Hap1
huntingtin-associated protein 1
chr4_+_9269285 14.986 ENSMUST00000038841.7
Clvs1
clavesin 1
chr6_+_83137089 12.274 ENSMUST00000121093.1
ENSMUST00000087938.4
Rtkn

rhotekin

chr14_-_67715585 11.947 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
Cdca2


cell division cycle associated 2


chr10_+_128790903 11.905 ENSMUST00000026411.6
Mmp19
matrix metallopeptidase 19
chr4_+_59581563 11.841 ENSMUST00000030078.5
Hsdl2
hydroxysteroid dehydrogenase like 2

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 374 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 71.6 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
13.1 39.4 GO:0006553 lysine metabolic process(GO:0006553)
4.2 37.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.7 32.7 GO:1902476 chloride transmembrane transport(GO:1902476)
1.7 29.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
6.1 24.5 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
3.3 23.2 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.5 23.2 GO:0015914 phospholipid transport(GO:0015914)
2.5 22.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.3 19.2 GO:0008156 negative regulation of DNA replication(GO:0008156)
4.6 18.5 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
1.8 18.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.4 18.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
2.3 18.2 GO:0016576 histone dephosphorylation(GO:0016576)
1.8 17.8 GO:0042573 retinoic acid metabolic process(GO:0042573)
3.3 16.7 GO:0035262 gonad morphogenesis(GO:0035262)
1.7 16.6 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
4.0 16.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 15.9 GO:0035411 catenin import into nucleus(GO:0035411)
3.1 15.6 GO:0032901 positive regulation of neurotrophin production(GO:0032901)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 78.6 GO:0005634 nucleus(GO:0005634)
0.3 66.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 65.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 43.5 GO:0005694 chromosome(GO:0005694)
0.2 26.7 GO:0005814 centriole(GO:0005814)
1.8 23.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 21.4 GO:0016607 nuclear speck(GO:0016607)
4.3 21.3 GO:0097149 centralspindlin complex(GO:0097149)
0.2 20.7 GO:0000922 spindle pole(GO:0000922)
6.5 19.4 GO:0071953 elastic fiber(GO:0071953)
4.8 19.3 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.4 16.0 GO:0034707 chloride channel complex(GO:0034707)
0.7 14.1 GO:0000145 exocyst(GO:0000145)
0.1 13.7 GO:0001650 fibrillar center(GO:0001650)
0.0 12.3 GO:0005730 nucleolus(GO:0005730)
1.3 11.5 GO:0030478 actin cap(GO:0030478)
0.1 11.5 GO:0032993 protein-DNA complex(GO:0032993)
2.3 11.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 11.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
3.1 9.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.8 39.4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
5.9 35.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 33.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
2.3 29.5 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.2 26.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 22.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 21.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.4 21.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 20.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 20.2 GO:0005548 phospholipid transporter activity(GO:0005548)
0.2 19.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
2.8 19.6 GO:0016918 retinal binding(GO:0016918)
1.0 19.2 GO:0035497 cAMP response element binding(GO:0035497)
0.3 18.5 GO:0070491 repressing transcription factor binding(GO:0070491)
1.1 18.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.4 18.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.0 17.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 16.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 15.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.6 14.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 79.3 PID_PLK1_PATHWAY PLK1 signaling events
0.3 43.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.9 40.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
1.2 21.4 ST_STAT3_PATHWAY STAT3 Pathway
0.3 16.7 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.3 12.0 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 11.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 10.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 10.0 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.2 9.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 9.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 9.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 9.2 PID_BARD1_PATHWAY BARD1 signaling events
0.3 8.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 8.5 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.2 7.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 7.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 5.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 5.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 5.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 56.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 27.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.8 21.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
1.2 19.5 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.8 18.0 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.5 17.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.6 16.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.4 16.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 16.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 13.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 12.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.5 11.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.6 11.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.3 10.6 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.5 10.5 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.2 10.4 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.3 9.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.3 8.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6 8.3 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 7.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors