Motif ID: Prdm1

Z-value: 1.138


Transcription factors associated with Prdm1:

Gene SymbolEntrez IDGene Name
Prdm1 ENSMUSG00000038151.6 Prdm1



Activity profile for motif Prdm1.

activity profile for motif Prdm1


Sorted Z-values histogram for motif Prdm1

Sorted Z-values for motif Prdm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prdm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 14.336 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr8_-_84800344 13.958 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr4_-_154636831 13.211 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr4_+_48049080 12.655 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr5_+_3343893 11.490 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr3_-_107760221 11.416 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr1_-_156674290 10.327 ENSMUST00000079625.4
 Tor3a
torsin family 3, member A
chr1_-_56978534 9.721 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr6_+_117168535 8.711 ENSMUST00000112866.1
ENSMUST00000112871.1
ENSMUST00000073043.4
 Cxcl12


chemokine (C-X-C motif) ligand 12


chr16_+_43363855 8.653 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr1_-_191183244 8.330 ENSMUST00000027941.8
 Atf3
activating transcription factor 3
chr11_-_77894096 8.107 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr2_+_116067213 8.050 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr16_+_43364145 7.893 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr15_+_32920723 7.515 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr13_-_23430826 7.094 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene

chr9_-_107668967 7.066 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr4_-_96591555 6.397 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr9_+_38718263 6.180 ENSMUST00000001544.5
ENSMUST00000118144.1
 Vwa5a

von Willebrand factor A domain containing 5A

chr3_-_101604580 6.146 ENSMUST00000036493.6
 Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 28.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 16.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.0 16.4 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
5.3 15.8 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
3.9 11.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
1.6 11.5 GO:0044838 cell quiescence(GO:0044838)
0.6 9.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.2 8.7 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
2.1 8.3 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
2.7 8.1 GO:0006553 lysine metabolic process(GO:0006553)
2.4 7.2 GO:0042196 dichloromethane metabolic process(GO:0018900) chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
1.4 7.1 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.4 6.9 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
1.5 6.1 GO:1903416 response to glycoside(GO:1903416)
0.1 6.1 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.7 6.0 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
2.0 5.9 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0 5.7 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 5.4 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.2 4.8 GO:1900027 regulation of ruffle assembly(GO:1900027)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.7 GO:0005925 focal adhesion(GO:0005925)
0.1 14.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 13.6 GO:0016235 aggresome(GO:0016235)
0.3 12.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
3.8 11.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 9.8 GO:0005667 transcription factor complex(GO:0005667)
0.1 9.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 8.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 8.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 6.3 GO:0016363 nuclear matrix(GO:0016363)
0.9 6.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 5.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.5 4.6 GO:0005588 collagen type V trimer(GO:0005588)
0.1 4.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 3.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.8 3.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 3.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 3.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.7 2.7 GO:0008537 proteasome activator complex(GO:0008537)
0.0 2.7 GO:0031519 PcG protein complex(GO:0031519)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 24.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 13.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.4 12.3 GO:0001223 transcription coactivator binding(GO:0001223)
3.8 11.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 11.5 GO:0005125 cytokine activity(GO:0005125)
0.5 10.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 9.6 GO:0016836 hydro-lyase activity(GO:0016836)
0.8 8.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
2.0 8.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
2.4 7.2 GO:0019120 hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
2.4 7.1 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 6.9 GO:0019843 rRNA binding(GO:0019843)
0.7 6.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.7 6.1 GO:1990239 steroid hormone binding(GO:1990239)
0.4 6.0 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
2.0 5.9 GO:0004454 ketohexokinase activity(GO:0004454)
0.3 5.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 4.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 4.4 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 11.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
1.1 11.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 9.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 8.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 6.6 PID_SHP2_PATHWAY SHP2 signaling
0.1 4.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 4.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 3.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.9 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 12.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 11.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 8.3 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.3 7.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 7.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.7 6.6 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3 6.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 6.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 5.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 5.7 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 5.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 4.8 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 4.2 REACTOME_METABOLISM_OF_CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 3.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 3.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 3.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 3.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 3.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC