Motif ID: Prop1

Z-value: 1.133


Transcription factors associated with Prop1:

Gene SymbolEntrez IDGene Name
Prop1 ENSMUSG00000044542.3 Prop1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prop1mm10_v2_chr11_-_50953745_50953768-0.009.9e-01Click!


Activity profile for motif Prop1.

activity profile for motif Prop1


Sorted Z-values histogram for motif Prop1

Sorted Z-values for motif Prop1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prop1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_45470201 16.852 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr18_-_66860458 16.812 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr10_-_64090241 14.780 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_+_94875600 14.331 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr18_-_13972617 11.766 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr9_+_118478182 11.524 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr10_-_64090265 11.225 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr9_+_118478344 11.049 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr1_+_6734827 11.017 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr14_-_40893222 9.886 ENSMUST00000096000.3
 Sh2d4b
SH2 domain containing 4B
chr2_+_61804453 9.303 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr14_+_75455957 8.894 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr4_-_110292719 8.647 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_107511416 8.517 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr3_+_146121655 7.408 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr18_-_62741387 7.167 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr16_-_16829276 6.902 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr3_+_94377432 6.785 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr3_+_94377505 6.090 ENSMUST00000098877.2
 Rorc
RAR-related orphan receptor gamma
chr12_-_55014329 5.800 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 26.0 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
7.5 22.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.9 16.9 GO:0010587 miRNA catabolic process(GO:0010587)
3.4 16.8 GO:0002024 diet induced thermogenesis(GO:0002024)
1.0 14.3 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.3 14.0 GO:0006284 base-excision repair(GO:0006284)
1.6 12.9 GO:0072615 interleukin-17 secretion(GO:0072615)
0.9 11.0 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.9 9.3 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
1.8 8.9 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.7 7.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.4 7.2 GO:0060467 negative regulation of fertilization(GO:0060467)
0.2 7.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 7.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 6.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 6.4 GO:0042491 auditory receptor cell differentiation(GO:0042491)
1.8 5.5 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
1.4 5.5 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.9 5.3 GO:2000790 regulation of mesenchymal cell proliferation involved in lung development(GO:2000790) negative regulation of mesenchymal cell proliferation involved in lung development(GO:2000791)
1.0 5.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.7 GO:0045211 postsynaptic membrane(GO:0045211)
2.4 16.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 11.3 GO:0005730 nucleolus(GO:0005730)
0.1 8.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.6 8.6 GO:0042788 polysomal ribosome(GO:0042788)
0.4 7.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.2 7.2 GO:0031262 Ndc80 complex(GO:0031262)
0.1 7.0 GO:0070469 respiratory chain(GO:0070469)
1.4 5.8 GO:0008623 CHRAC(GO:0008623)
1.8 5.5 GO:0035061 interchromatin granule(GO:0035061)
0.4 5.5 GO:0070852 cell body fiber(GO:0070852)
0.8 4.9 GO:0044305 calyx of Held(GO:0044305)
0.0 4.4 GO:0005923 bicellular tight junction(GO:0005923)
0.7 4.3 GO:0045179 apical cortex(GO:0045179)
0.0 4.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 4.0 GO:0005776 autophagosome(GO:0005776)
0.5 3.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 3.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.4 3.2 GO:0002177 manchette(GO:0002177)
0.3 3.2 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.4 25.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.8 17.9 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
5.6 16.8 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.3 15.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
3.2 12.9 GO:0008142 oxysterol binding(GO:0008142)
0.1 10.1 GO:0001047 core promoter binding(GO:0001047)
0.1 9.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 9.2 GO:0008270 zinc ion binding(GO:0008270)
0.1 8.9 GO:0005496 steroid binding(GO:0005496)
0.2 8.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 7.7 GO:0030507 spectrin binding(GO:0030507)
0.1 6.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
1.8 5.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.2 5.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.7 5.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
1.6 4.9 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.7 4.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.5 4.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
1.3 3.9 GO:0050501 hyaluronan synthase activity(GO:0050501)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 33.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 24.6 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.8 14.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 8.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 4.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 3.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 3.2 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 2.3 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 1.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
2.1 16.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 16.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 13.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 10.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.8 5.5 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.2 5.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.5 5.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 4.2 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT Genes involved in Aquaporin-mediated transport
0.0 4.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 3.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.9 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.1 3.3 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 3.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 3.1 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 2.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 2.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation