Motif ID: Prox1
Z-value: 0.545
Transcription factors associated with Prox1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Prox1 | ENSMUSG00000010175.7 | Prox1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Prox1 | mm10_v2_chr1_-_190170671_190170744 | -0.38 | 5.7e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.6 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 1.1 | 3.2 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.7 | 4.7 | GO:0032811 | negative regulation of epinephrine secretion(GO:0032811) |
| 0.6 | 1.7 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.4 | 1.2 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.3 | 0.9 | GO:0019389 | urate transport(GO:0015747) glucuronoside metabolic process(GO:0019389) negative regulation of intestinal absorption(GO:1904479) |
| 0.3 | 2.0 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.2 | 0.6 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.2 | 2.8 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.2 | 0.7 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.2 | 1.3 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.2 | 0.8 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.1 | 3.2 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
| 0.1 | 0.4 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.1 | 0.4 | GO:0038108 | negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) |
| 0.1 | 2.0 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.1 | 0.5 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 0.8 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.1 | 0.6 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.1 | 3.8 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.1 | 10.0 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 0.2 | GO:0010796 | regulation of multivesicular body size(GO:0010796) |
| 0.1 | 2.5 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 0.2 | GO:0090292 | nuclear matrix organization(GO:0043578) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) nuclear matrix anchoring at nuclear membrane(GO:0090292) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.0 | 0.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 1.6 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.0 | 1.5 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 1.4 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 2.9 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 1.1 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.0 | 0.3 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.0 | 1.0 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 0.7 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.1 | GO:2001184 | regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.0 | 0.3 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 0.9 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.0 | 0.5 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 1.2 | GO:0009566 | fertilization(GO:0009566) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.0 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.2 | 3.2 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.2 | 1.3 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.1 | 2.0 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 3.2 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 0.4 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.1 | 1.9 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 1.0 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 2.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 0.6 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 0.2 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.7 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 10.0 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 1.0 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.0 | 0.2 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 1.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 1.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.7 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 4.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.7 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 1.6 | GO:0055037 | recycling endosome(GO:0055037) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.6 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.5 | 3.0 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.5 | 2.8 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.4 | 1.2 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.4 | 1.1 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.4 | 2.9 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.2 | 0.9 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.2 | 0.5 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.1 | 0.7 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.1 | 2.0 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.1 | 3.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.6 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.1 | 1.6 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 1.2 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.1 | 0.6 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 1.0 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.4 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 1.8 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 0.7 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 3.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 2.9 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 1.4 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 1.7 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.3 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 1.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.2 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 0.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.2 | GO:0031489 | myosin V binding(GO:0031489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.1 | 2.1 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 2.8 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.9 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.7 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.0 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.5 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.2 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 0.9 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 1.1 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 1.7 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 0.6 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 0.9 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 3.8 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 2.0 | REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 4.6 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 0.7 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 3.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 1.6 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.8 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.2 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.0 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.5 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.8 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.3 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 1.4 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
