Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.728

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrxl1mm10_v2_chr14_+_32599922_32599932-0.351.8e-03Click!
Prrx1mm10_v2_chr1_-_163313661_1633137100.333.9e-03Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_79386943 11.827 ENSMUST00000053718.8
ENSMUST00000179243.1
Rlbp1

retinaldehyde binding protein 1

chr14_+_80000292 6.534 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr2_-_160619971 6.429 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr14_-_101609033 5.536 ENSMUST00000161991.1
ENSMUST00000100340.3
Tbc1d4

TBC1 domain family, member 4

chr9_+_118478182 4.763 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr3_+_86070915 4.586 ENSMUST00000182666.1
Sh3d19
SH3 domain protein D19
chr9_+_118478344 4.576 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chr15_-_8710734 4.124 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_62766153 4.119 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_+_9029982 4.039 ENSMUST00000085741.1
Ttc32
tetratricopeptide repeat domain 32
chr2_+_116067213 4.026 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr4_+_5724304 3.892 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr3_-_49757257 3.653 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr5_-_124095749 3.620 ENSMUST00000031354.4
Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr1_+_58210397 3.337 ENSMUST00000040442.5
Aox4
aldehyde oxidase 4
chr4_-_87806296 3.148 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr15_-_8710409 3.032 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_32923455 3.028 ENSMUST00000035719.4
ENSMUST00000084749.1
Ankrd6

ankyrin repeat domain 6

chr11_+_94936224 2.925 ENSMUST00000001547.7
Col1a1
collagen, type I, alpha 1
chr4_-_87806276 2.923 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chrM_+_11734 2.812 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr11_-_117873433 2.616 ENSMUST00000033230.7
Tha1
threonine aldolase 1
chr1_-_163725123 2.596 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr2_+_91257323 2.507 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr18_+_37320374 2.491 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chr9_+_80165079 2.398 ENSMUST00000184480.1
Myo6
myosin VI
chr17_+_78508063 2.377 ENSMUST00000024880.9
Vit
vitrin
chr1_-_56969864 2.370 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr17_+_3397189 2.192 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr8_-_106573461 2.062 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr14_-_118052235 2.036 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr2_-_170194033 1.996 ENSMUST00000180625.1
Gm17619
predicted gene, 17619
chr2_-_116067391 1.946 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr1_-_56969827 1.930 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr9_-_71896047 1.918 ENSMUST00000184448.1
Tcf12
transcription factor 12
chr9_-_42399915 1.901 ENSMUST00000042190.7
Tecta
tectorin alpha
chr1_-_24005608 1.873 ENSMUST00000027338.3
1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr9_-_42399709 1.858 ENSMUST00000160940.1
Tecta
tectorin alpha
chr14_-_76010863 1.841 ENSMUST00000088922.4
Gtf2f2
general transcription factor IIF, polypeptide 2
chr18_+_60774675 1.803 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chr19_-_43912392 1.794 ENSMUST00000026209.4
Dnmbp
dynamin binding protein
chr18_+_69593361 1.778 ENSMUST00000114978.2
ENSMUST00000114977.1
Tcf4

transcription factor 4

chr6_-_37442095 1.775 ENSMUST00000041093.5
Creb3l2
cAMP responsive element binding protein 3-like 2
chr18_+_60774510 1.757 ENSMUST00000025511.3
Rps14
ribosomal protein S14
chr2_-_33942111 1.738 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
Gm13403


predicted gene 13403


chr2_+_155751117 1.672 ENSMUST00000029140.5
ENSMUST00000132608.1
Procr

protein C receptor, endothelial

chr8_-_105966038 1.661 ENSMUST00000116429.2
ENSMUST00000034370.9
Slc12a4

solute carrier family 12, member 4

chr15_+_81744848 1.611 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr1_-_144177259 1.602 ENSMUST00000111941.1
ENSMUST00000052375.1
Rgs13

regulator of G-protein signaling 13

chrX_+_99975570 1.601 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr12_-_25096080 1.588 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr2_+_91256813 1.581 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr17_+_56613392 1.531 ENSMUST00000080492.5
Rpl36
ribosomal protein L36
chr2_-_155945282 1.505 ENSMUST00000040162.2
Gdf5
growth differentiation factor 5
chr11_+_53433299 1.494 ENSMUST00000018382.6
Gdf9
growth differentiation factor 9
chr3_+_66219909 1.475 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr13_+_44121167 1.444 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chr12_+_79297345 1.427 ENSMUST00000079533.5
ENSMUST00000171210.1
Rad51b

RAD51 homolog B

chrX_+_38600626 1.426 ENSMUST00000000365.2
Mcts1
malignant T cell amplified sequence 1
chr7_-_127895578 1.387 ENSMUST00000033074.6
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr13_-_105271039 1.383 ENSMUST00000069686.6
Rnf180
ring finger protein 180
chr18_-_78206408 1.380 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr3_+_84593547 1.369 ENSMUST00000062623.3
Tigd4
tigger transposable element derived 4
chr4_+_154964117 1.357 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr18_-_39487096 1.348 ENSMUST00000097592.2
ENSMUST00000115571.1
Nr3c1

nuclear receptor subfamily 3, group C, member 1

chr5_-_35105691 1.344 ENSMUST00000030986.8
Lrpap1
low density lipoprotein receptor-related protein associated protein 1
chr8_+_23411490 1.343 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chr8_+_94172618 1.312 ENSMUST00000034214.6
Mt2
metallothionein 2
chr3_+_89715016 1.302 ENSMUST00000098924.2
Adar
adenosine deaminase, RNA-specific
chr8_+_121116163 1.286 ENSMUST00000054691.6
Foxc2
forkhead box C2
chr2_-_34913976 1.286 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr7_+_140941550 1.257 ENSMUST00000079403.4
Athl1
ATH1, acid trehalase-like 1 (yeast)
chr17_-_36042690 1.207 ENSMUST00000058801.8
ENSMUST00000080015.5
ENSMUST00000077960.6
H2-T22


histocompatibility 2, T region locus 22


chrX_+_163911401 1.201 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr18_-_13972617 1.197 ENSMUST00000025288.7
Zfp521
zinc finger protein 521
chr7_+_132610620 1.196 ENSMUST00000033241.5
Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr8_-_120228221 1.191 ENSMUST00000183235.1
A330074K22Rik
RIKEN cDNA A330074K22 gene
chr11_+_32000452 1.177 ENSMUST00000020537.2
ENSMUST00000109409.1
Nsg2

neuron specific gene family member 2

chr4_-_82505749 1.174 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib

nuclear factor I/B

chr4_+_102589687 1.158 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr7_-_79848191 1.145 ENSMUST00000107392.1
Anpep
alanyl (membrane) aminopeptidase
chr15_-_37459327 1.133 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr11_+_113684412 1.097 ENSMUST00000042227.8
ENSMUST00000123466.1
ENSMUST00000106621.3
D11Wsu47e


DNA segment, Chr 11, Wayne State University 47, expressed


chr4_-_82505274 1.074 ENSMUST00000050872.8
ENSMUST00000064770.2
Nfib

nuclear factor I/B

chr12_-_4841583 1.074 ENSMUST00000020964.5
Fkbp1b
FK506 binding protein 1b
chr7_-_46667375 1.053 ENSMUST00000107669.2
Tph1
tryptophan hydroxylase 1
chrM_+_8600 1.049 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr18_-_66860458 1.045 ENSMUST00000057942.2
Mc4r
melanocortin 4 receptor
chr6_-_83121385 1.038 ENSMUST00000146328.1
ENSMUST00000113936.3
ENSMUST00000032111.4
Wbp1


WW domain binding protein 1


chr17_-_45599603 1.038 ENSMUST00000171847.1
ENSMUST00000166633.1
ENSMUST00000169729.1
Slc29a1


solute carrier family 29 (nucleoside transporters), member 1


chrX_+_159708593 1.034 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr13_+_94788873 1.015 ENSMUST00000046644.5
Tbca
tubulin cofactor A
chr7_+_19368498 1.006 ENSMUST00000132655.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr9_+_119341487 0.992 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr1_-_158356258 0.991 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr16_+_33684460 0.981 ENSMUST00000152782.1
ENSMUST00000179453.1
Heg1

HEG homolog 1 (zebrafish)

chr11_-_98729374 0.965 ENSMUST00000126565.1
ENSMUST00000100500.2
ENSMUST00000017354.6
Med24


mediator complex subunit 24


chr10_+_99263224 0.961 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr11_+_35121126 0.947 ENSMUST00000069837.3
Slit3
slit homolog 3 (Drosophila)
chr11_-_113684155 0.946 ENSMUST00000120194.1
Fam104a
family with sequence similarity 104, member A
chr3_+_88579602 0.942 ENSMUST00000035785.7
Ssr2
signal sequence receptor, beta
chr13_+_96388294 0.935 ENSMUST00000099295.4
Poc5
POC5 centriolar protein homolog (Chlamydomonas)
chr2_-_29787622 0.926 ENSMUST00000177467.1
ENSMUST00000113807.3
Trub2

TruB pseudouridine (psi) synthase homolog 2 (E. coli)

chr10_-_42583628 0.921 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr7_+_45526330 0.919 ENSMUST00000120985.1
ENSMUST00000051810.8
Plekha4

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

chr5_-_62765618 0.906 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_170308802 0.871 ENSMUST00000056991.5
1700015E13Rik
RIKEN cDNA 1700015E13 gene
chr4_-_24430838 0.859 ENSMUST00000183964.1
RP23-35K5.2
RP23-35K5.2
chr14_-_18893376 0.855 ENSMUST00000151926.1
Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr9_-_89705017 0.850 ENSMUST00000058488.6
Tmed3
transmembrane emp24 domain containing 3
chr4_-_82505707 0.836 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib

nuclear factor I/B

chr15_+_99006056 0.830 ENSMUST00000079818.3
Gm8973
predicted gene 8973
chr10_+_127421208 0.828 ENSMUST00000168780.1
R3hdm2
R3H domain containing 2
chr17_-_36032682 0.817 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr18_+_75000469 0.807 ENSMUST00000079716.5
Rpl17
ribosomal protein L17
chr9_-_71163224 0.801 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr3_-_66296807 0.799 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr8_+_54954728 0.797 ENSMUST00000033915.7
Gpm6a
glycoprotein m6a
chr7_+_19508712 0.793 ENSMUST00000002112.8
ENSMUST00000108455.1
Trappc6a

trafficking protein particle complex 6A

chr18_+_37400845 0.782 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr17_-_37483543 0.779 ENSMUST00000016427.4
ENSMUST00000171139.2
H2-M2

histocompatibility 2, M region locus 2

chr2_-_84650760 0.776 ENSMUST00000111691.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr6_+_17749170 0.770 ENSMUST00000053148.7
ENSMUST00000115417.3
St7

suppression of tumorigenicity 7

chr9_+_119341294 0.756 ENSMUST00000039784.5
Acaa1a
acetyl-Coenzyme A acyltransferase 1A
chr18_+_38993126 0.753 ENSMUST00000097593.2
Arhgap26
Rho GTPase activating protein 26
chrM_+_10167 0.741 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr16_+_16870736 0.739 ENSMUST00000139740.1
ENSMUST00000119787.2
ENSMUST00000130650.1
ENSMUST00000156502.1
ENSMUST00000023465.7
ENSMUST00000124960.1
ENSMUST00000144513.1
Top3b






topoisomerase (DNA) III beta






chr2_+_20737306 0.737 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr4_-_132463873 0.737 ENSMUST00000102567.3
Med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr9_+_92457369 0.725 ENSMUST00000034941.7
Plscr4
phospholipid scramblase 4
chr11_+_109543694 0.713 ENSMUST00000106696.1
Arsg
arylsulfatase G
chr7_-_45526146 0.698 ENSMUST00000167273.1
ENSMUST00000042105.8
Ppp1r15a

protein phosphatase 1, regulatory (inhibitor) subunit 15A

chr8_-_105637403 0.693 ENSMUST00000182046.1
Gm5914
predicted gene 5914
chr10_-_127189981 0.678 ENSMUST00000019611.7
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr8_-_105568298 0.672 ENSMUST00000005849.5
Agrp
agouti related protein
chr11_-_59163281 0.664 ENSMUST00000069631.2
Iba57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr8_-_105484350 0.661 ENSMUST00000044286.5
Zdhhc1
zinc finger, DHHC domain containing 1
chr15_+_98571004 0.651 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr3_-_86142684 0.637 ENSMUST00000029722.6
Rps3a1
ribosomal protein S3A1
chr1_+_167598384 0.627 ENSMUST00000015987.3
Rxrg
retinoid X receptor gamma
chr7_+_67655414 0.625 ENSMUST00000107470.1
Ttc23
tetratricopeptide repeat domain 23
chr2_-_84425258 0.624 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr3_-_57294880 0.622 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr19_+_8802486 0.620 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr15_+_76343504 0.616 ENSMUST00000023210.6
Cyc1
cytochrome c-1
chr2_+_52038005 0.611 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr1_-_152625212 0.602 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr11_+_32000496 0.601 ENSMUST00000093219.3
Nsg2
neuron specific gene family member 2
chr7_+_126976338 0.600 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr3_-_98339921 0.598 ENSMUST00000065793.5
Phgdh
3-phosphoglycerate dehydrogenase
chr11_-_115419917 0.584 ENSMUST00000106537.1
ENSMUST00000043931.2
ENSMUST00000073791.3
Atp5h


ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d


chr8_+_71542911 0.569 ENSMUST00000034272.7
Mvb12a
multivesicular body subunit 12A
chr14_+_74735641 0.567 ENSMUST00000177283.1
Esd
esterase D/formylglutathione hydrolase
chr16_-_90810365 0.559 ENSMUST00000140920.1
Urb1
URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
chr2_-_34826071 0.553 ENSMUST00000113077.1
ENSMUST00000028220.3
Fbxw2

F-box and WD-40 domain protein 2

chr18_+_34758890 0.548 ENSMUST00000049281.5
Fam53c
family with sequence similarity 53, member C
chr14_+_24490678 0.548 ENSMUST00000169826.1
ENSMUST00000112384.3
Rps24

ribosomal protein S24

chr6_+_58831748 0.544 ENSMUST00000126292.1
ENSMUST00000031823.5
Herc3

hect domain and RLD 3

chr17_-_51826562 0.538 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1




special AT-rich sequence binding protein 1




chr3_-_59220150 0.535 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr9_+_48362034 0.532 ENSMUST00000093853.4
Nxpe4
neurexophilin and PC-esterase domain family, member 4
chr19_+_5474681 0.531 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr17_-_15498263 0.531 ENSMUST00000014913.9
Psmb1
proteasome (prosome, macropain) subunit, beta type 1
chr13_-_4609122 0.530 ENSMUST00000110691.3
ENSMUST00000091848.5
Akr1e1

aldo-keto reductase family 1, member E1

chrX_+_106015699 0.529 ENSMUST00000033582.4
Cox7b
cytochrome c oxidase subunit VIIb
chr10_+_127420867 0.528 ENSMUST00000064793.6
R3hdm2
R3H domain containing 2
chr10_+_79996479 0.525 ENSMUST00000132517.1
Abca7
ATP-binding cassette, sub-family A (ABC1), member 7
chr11_+_58171648 0.521 ENSMUST00000020820.1
Mrpl22
mitochondrial ribosomal protein L22
chr1_+_167598450 0.510 ENSMUST00000111386.1
ENSMUST00000111384.1
Rxrg

retinoid X receptor gamma

chr17_-_24073479 0.509 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr2_+_30952955 0.504 ENSMUST00000028199.5
Tor1b
torsin family 1, member B
chr2_-_130664565 0.498 ENSMUST00000089559.4
Ddrgk1
DDRGK domain containing 1
chrX_+_56963325 0.496 ENSMUST00000096431.3
Gpr112
G protein-coupled receptor 112
chr13_-_81570640 0.496 ENSMUST00000109565.2
Gpr98
G protein-coupled receptor 98
chr4_+_115839192 0.490 ENSMUST00000019677.5
ENSMUST00000144427.1
ENSMUST00000106513.3
ENSMUST00000130819.1
ENSMUST00000151203.1
ENSMUST00000140315.1
Mknk1





MAP kinase-interacting serine/threonine kinase 1





chr10_-_88605017 0.480 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr3_+_66985947 0.480 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr12_+_117843489 0.478 ENSMUST00000021592.9
Cdca7l
cell division cycle associated 7 like
chr3_+_90476121 0.470 ENSMUST00000001042.8
Ilf2
interleukin enhancer binding factor 2
chr10_+_127421124 0.460 ENSMUST00000170336.1
R3hdm2
R3H domain containing 2
chr18_+_37755718 0.454 ENSMUST00000061279.7
Pcdhga9
protocadherin gamma subfamily A, 9
chr3_+_87906842 0.452 ENSMUST00000159492.1
Hdgf
hepatoma-derived growth factor
chr9_+_66946057 0.447 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr18_-_20682963 0.446 ENSMUST00000165229.2
Gm10269
predicted gene 10269
chr18_+_37411674 0.442 ENSMUST00000051126.2
Pcdhb10
protocadherin beta 10
chr4_+_110397661 0.438 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
Agbl4



ATP/GTP binding protein-like 4



chr3_-_37125943 0.438 ENSMUST00000029275.5
Il2
interleukin 2
chr15_+_102326369 0.437 ENSMUST00000169637.1
ENSMUST00000165671.1
Pfdn5

prefoldin 5

chr5_+_64092925 0.434 ENSMUST00000087324.5
Pgm1
phosphoglucomutase 1
chr15_+_78935177 0.431 ENSMUST00000145157.1
ENSMUST00000123013.1
Nol12

nucleolar protein 12

chr10_+_79704499 0.422 ENSMUST00000067036.5
ENSMUST00000178383.1
Bsg

basigin

chr16_-_45693658 0.418 ENSMUST00000114562.2
ENSMUST00000036617.7
Tmprss7

transmembrane serine protease 7

chrX_-_150814265 0.417 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chr8_-_46294592 0.414 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr15_+_102326400 0.414 ENSMUST00000165717.1
Pfdn5
prefoldin 5
chr9_-_114982739 0.405 ENSMUST00000053150.5
Gm9846
predicted gene 9846
chr4_+_43493345 0.404 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chr17_+_47611570 0.404 ENSMUST00000024778.2
Med20
mediator complex subunit 20
chr5_-_87482258 0.402 ENSMUST00000079811.6
ENSMUST00000144144.1
Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr14_-_57571551 0.400 ENSMUST00000022518.5
N6amt2
N-6 adenine-specific DNA methyltransferase 2 (putative)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.8 7.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.1 3.3 GO:0046110 xanthine metabolic process(GO:0046110)
1.1 3.2 GO:0006566 threonine metabolic process(GO:0006566)
0.8 3.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.6 5.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.6 2.9 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.6 9.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.5 1.6 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.5 1.4 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.5 1.4 GO:0071918 urea transmembrane transport(GO:0071918)
0.4 1.3 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.4 1.3 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.4 1.3 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.4 2.9 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 8.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.4 1.4 GO:0002188 translation reinitiation(GO:0002188)
0.3 2.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 1.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.3 1.0 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.3 1.5 GO:0060591 chondroblast differentiation(GO:0060591)
0.3 1.5 GO:0042701 progesterone secretion(GO:0042701)
0.3 1.5 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.3 0.8 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.3 1.3 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 1.3 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.3 0.5 GO:1902995 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
0.3 1.0 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.2 1.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.2 0.7 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 1.0 GO:0002024 diet induced thermogenesis(GO:0002024)
0.2 0.6 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 0.4 GO:0072106 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
0.2 4.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 0.6 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.2 1.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 0.5 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 4.3 GO:0002076 osteoblast development(GO:0002076)
0.2 2.4 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.2 1.7 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.2 3.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 0.8 GO:0046689 response to mercury ion(GO:0046689)
0.2 0.8 GO:1903232 melanosome assembly(GO:1903232)
0.2 0.9 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.2 0.6 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.2 0.8 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.2 0.6 GO:0033762 response to glucagon(GO:0033762)
0.2 1.1 GO:0060315 response to redox state(GO:0051775) negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2 0.9 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.2 1.7 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.0 GO:0015862 uridine transport(GO:0015862)
0.1 0.7 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 1.8 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 1.1 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 11.2 GO:0007601 visual perception(GO:0007601)
0.1 5.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.6 GO:1903772 regulation of viral budding via host ESCRT complex(GO:1903772)
0.1 0.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.4 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.7 GO:0008343 adult feeding behavior(GO:0008343)
0.1 0.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.7 GO:0006265 DNA topological change(GO:0006265)
0.1 0.3 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 1.1 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 0.3 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632) regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.1 0.3 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 0.5 GO:1990564 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 4.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 0.3 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 2.6 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 1.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.7 GO:0008206 bile acid metabolic process(GO:0008206)
0.1 0.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.9 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 1.0 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.1 0.2 GO:0001887 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
0.1 2.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 0.2 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.1 1.0 GO:0022904 respiratory electron transport chain(GO:0022904)
0.1 0.9 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 1.7 GO:0050819 negative regulation of coagulation(GO:0050819)
0.1 0.3 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 0.3 GO:0015817 histidine transport(GO:0015817)
0.1 0.5 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.3 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.0 0.5 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.0 0.1 GO:1903546 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019) protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.9 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 1.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 1.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.3 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 2.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 2.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 1.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 4.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.3 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0 0.3 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.0 1.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.2 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 1.8 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.2 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 4.1 GO:0007416 synapse assembly(GO:0007416)
0.0 0.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.3 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 0.3 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 0.2 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.3 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 2.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.2 GO:0048478 replication fork protection(GO:0048478)
0.0 0.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.1 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:1901663 quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.4 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 0.0 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0001575 globoside metabolic process(GO:0001575)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.0 GO:0019085 early viral transcription(GO:0019085) late viral transcription(GO:0019086)
0.0 0.1 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0005584 collagen type I trimer(GO:0005584)
0.5 6.5 GO:0042581 specific granule(GO:0042581)
0.3 1.1 GO:0031983 vesicle lumen(GO:0031983)
0.3 1.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 1.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 1.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 1.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 2.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 7.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.7 GO:0070847 core mediator complex(GO:0070847)
0.1 5.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.9 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.6 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.1 2.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.1 0.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.6 GO:0000813 ESCRT I complex(GO:0000813)
0.1 4.6 GO:0070469 respiratory chain(GO:0070469)
0.1 0.9 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.1 1.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 4.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.3 GO:0005687 U4 snRNP(GO:0005687)
0.0 3.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 4.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.2 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.3 GO:0034709 methylosome(GO:0034709)
0.0 7.6 GO:0044297 cell body(GO:0044297)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 8.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 4.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.0 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.6 GO:0043209 myelin sheath(GO:0043209)
0.0 0.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.8 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 11.8 GO:0019841 retinol binding(GO:0019841)
1.2 7.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 2.6 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.8 3.3 GO:0030151 molybdenum ion binding(GO:0030151)
0.7 3.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.4 1.3 GO:0048019 receptor antagonist activity(GO:0048019)
0.4 1.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 1.7 GO:0008410 CoA-transferase activity(GO:0008410)
0.4 1.3 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.4 5.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 2.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.4 1.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.3 1.0 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.3 1.3 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 3.6 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.3 1.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.3 1.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 1.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 1.8 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 1.5 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.8 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.2 1.4 GO:0000150 recombinase activity(GO:0000150)
0.2 2.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 3.7 GO:0035497 cAMP response element binding(GO:0035497)
0.2 0.6 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.2 0.5 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 4.6 GO:0070064 proline-rich region binding(GO:0070064)
0.2 2.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 9.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 4.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.9 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 1.4 GO:0048038 quinone binding(GO:0048038)
0.1 3.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.8 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.4 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 5.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 3.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.5 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.6 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.4 GO:0008494 translation activator activity(GO:0008494)
0.1 0.4 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 1.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 0.3 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
0.1 0.7 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.0 0.4 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 1.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.3 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 3.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 4.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 6.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.1 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.0 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0019843 rRNA binding(GO:0019843)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.2 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 1.8 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 5.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 4.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 1.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.8 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 8.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 3.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 5.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.9 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 PID_P73PATHWAY p73 transcription factor network
0.0 1.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.2 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 1.4 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 1.8 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 7.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 3.1 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 0.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 5.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 4.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.5 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 3.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 0.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.0 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 5.0 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 2.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.9 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.3 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 2.9 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.3 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 3.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)